Results 201 to 210 of about 85,087 (299)

Progressive Cognitive Decline and Pyramidal Signs in a Patient With a Novel Homozygous c.395A>T; p.Lys132Met Mutation in CHCHD2

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Biallelic CHCHD2 variants are rare. We report a consanguineous man with a novel homozygous CHCHD2 c.395A>T (p.Lys132Met) variant who developed progressive cognitive decline, apraxia, oculomotor impairment, and pyramidal signs without parkinsonism.
Mehri Salari, Arash Soltani, Masoud Etemadifar, Kamran Rezaei   +3 more
wiley   +1 more source

Nanotechnology-based detoxification of profenofos using red blood cell membrane-coated polymeric nanoparticles. [PDF]

BMC Pharmacol Toxicol
Altaf S, Muhammad F, Abbas RZ, Abdel-Maksoud MA, Alrokayan S, Alsabih AO.   +5 more
europepmc   +1 more source

Antipsychotic Drug Interactions and Short‐Term Mortality Risk in People With Dementia: A National Cohort Study

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 1081-1091, October 2026.
Antipsychotics are often prescribed in the management of behaviors and psychological symptoms of dementia. While the potential harms of antipsychotic use in people with dementia have been established, little is known about the risk associated with antipsychotic drug–drug interactions (DDIs). This study aims to examine the patterns of antipsychotic DDIs
Edward C.Y. Lau, Grace H. Shim, Chin Hang Yiu, Sarah N. Hilmer, Yun‐Hee Jeon, Weisi Chen, Christine Y. Lu, Edwin C.K. Tan   +7 more
wiley   +1 more source

High-performance liquid chromatography - diode array detection method validation for amentoflavone-type biflavonoids in five Encephalartos species with potential neuroprotective activity. [PDF]

Sci Rep
El-Natory ZG, Ahmed HS, Amir DE, Abdelwahab NS, Moawad A.   +4 more
europepmc   +1 more source

Metformin Attenuates Behavioral Deficits and Oxidative Stress in a Preclinical Model of Autism

Developmental Neurobiology, Volume 86, Issue 4, October 2026.
ABSTRACT Autism spectrum disorder (ASD) is a complex neurodevelopmental condition lacking effective pharmacological treatments. Metformin has emerged as a candidate for drug repurposing in ASD due to its metabolic and neurobiological actions. This study evaluated the in vivo effects of metformin (400 mg/kg, orally) administered from postnatal day 21 to
Madna Costa Freitas, Renê Felipe de Freitas, Iara Kessila Milhome Vasconcelos, Isadora Porto de Andrade, Maria Helena da Silva Pitombeira, David Ribeiro Fontenele, Pedro Otávio de Freitas Alves, Victoria Soares Diógenes, Ana Maria Sampaio Assreuy, Gislei Frota Aragão   +9 more
wiley   +1 more source

Effects of <i>Piper hemmendorffii</i> (Piperales: Piperaceae) Essential Oil and Limonene on Modulation of Phase I Detoxifying Enzymes and Acetylcholinesterase Activity of <i>Rhipicephalus microplus</i> (Acari: Ixodidae). [PDF]

Pathogens
Pereira Filho AA, Vale VFD, Monteiro CMO, Barrozo MM, Rodrigues DS, Yamaguchi LF, Kato MJ, Araujo RN.   +7 more
europepmc   +1 more source

Microplastics as Emerging Neurotoxins: Brain Accumulation, Neuroinflammation, and Neurodegeneration Risk

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Microplastics and nanoplastics (MPs/NPs) are emerging environmental neurotoxicants capable of accumulating in the human brain through blood‐brain barrier transcytosis and olfactory transport pathways. Once within the central nervous system, MPs/NPs trigger interconnected mechanisms including NLRP3 inflammasome activation, oxidative stress ...
Alfi Sophian, Asmariani, Erika Ismayani
wiley   +1 more source

Computational design and evaluation of tacrine-based carbamate derivatives as acetylcholinesterase inhibitors. [PDF]

RSC Adv
El Ouarti H, Toughzaoui A, Laourdani K, Drajou A, Dakhama A, Raza U, Bensaka M, M M Hamed L, Azzaoui K, Belkheir H, El-Harairy A, Moradi K, Ouammou A.   +12 more
europepmc   +1 more source

Novel Pyrazole‐4‐Carbaldehyde Derivatives Having Potent COX‐2 Inhibition and Anti‐Tubercular Activity: Microwave‐Assisted Green Synthesis and Molecular Docking

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
ABSTRACT A series of 1‐(4‐Chorophenyl)‐3Aryl‐1‐H‐pyrazole‐4‐carbaldehyde derivatives were synthesized under the microwave irradiation (MW) technique. IR, 1H‐NMR, 13C‐NMR, and mass spectroscopic techniques were used to confirm the structure of the synthesized compounds.
Megha Kokane, Dnyandev Bhosale, Dattatraya Raut, Pushpa Hadimani, Ashwini Narale, Prafulla Choudhari, Anjana Lawand   +6 more
wiley   +1 more source

Treatment of Parkinson's Disease-Related Psychosis. [PDF]

Clin Pharmacol
Rocha NP, Moreira Sassi KL, Furr Stimming E, Teixeira AL.   +3 more
europepmc   +1 more source