Results 211 to 220 of about 51,436 (262)
Some of the next articles are maybe not open access.
Angewandte Chemie International Edition in English, 1967
AbstractAcetylcholinesterase plays a vital part in the functioning of nerves, and serious physiological damage arises from its blockage by esters of phosphonic and phosphoric acid used e. g. in pesticides. The properties and the mechanism of action of acetylcholinesterase, which show many similarities to those of other hydrolases, are described ...
N, Engelhard, K, Prchal, M, Nenner
openaire +2 more sources
AbstractAcetylcholinesterase plays a vital part in the functioning of nerves, and serious physiological damage arises from its blockage by esters of phosphonic and phosphoric acid used e. g. in pesticides. The properties and the mechanism of action of acetylcholinesterase, which show many similarities to those of other hydrolases, are described ...
N, Engelhard, K, Prchal, M, Nenner
openaire +2 more sources
Tetrahydrocannabinol and acetylcholinesterase
Pharmacology Biochemistry and Behavior, 1978Recent evidence suggests that the psychoactive effect of delta-9-tetrahydrocannabinol (delta9-THC), the major psychoactive constituent of marihuana, may be mediated through an alteration of cholinergic neurotransmission. One possible mechanism by which delta9-THC could have its effect is by affecting acetylcholinesterase (AChE) and there is evidence ...
D E, Moss, P L, Peck, R, Salome
openaire +2 more sources
Biophysics of Structure and Mechanism, 1980
Three mechanisms have been suggested to describe the inhibition of acetylcholinesterase (EC. 3.1.1.7) by an excess of acetylcholine. (i) Substrate inhibition occurs through the reaction of acetylcholine with acetylated enzyme. The deacetylation of this ternary complex is supposed to be completely inhibited.
P, Hofer, U P, Fringeli
openaire +2 more sources
Three mechanisms have been suggested to describe the inhibition of acetylcholinesterase (EC. 3.1.1.7) by an excess of acetylcholine. (i) Substrate inhibition occurs through the reaction of acetylcholine with acetylated enzyme. The deacetylation of this ternary complex is supposed to be completely inhibited.
P, Hofer, U P, Fringeli
openaire +2 more sources
Molecular Dynamics of Acetylcholinesterase
Accounts of Chemical Research, 2002Molecular dynamics simulations are leading to a deeper understanding of the activity of the enzyme acetylcholinesterase. Simulations have shown how breathing motions in the enzyme facilitate the displacement of substrate from the surface of the enzyme to the buried active site.
Shen, Tongye +3 more
openaire +2 more sources
Canadian Journal of Biochemistry, 1964
The general characteristics of acetylcholinesterase are described. The mechanism of action of the enzyme is considered primarily in relation to the two steps in the hydrolysis of acetylcholine, the acetylation and deacetylation reactions. Competitive and non-competitive inhibition, and inhibitions by hydrogen ion and by substrate, are explained in ...
openaire +2 more sources
The general characteristics of acetylcholinesterase are described. The mechanism of action of the enzyme is considered primarily in relation to the two steps in the hydrolysis of acetylcholine, the acetylation and deacetylation reactions. Competitive and non-competitive inhibition, and inhibitions by hydrogen ion and by substrate, are explained in ...
openaire +2 more sources
Toward an Artificial Acetylcholinesterase
Chemistry - A European Journal, 2000The methanolysis of choline p-nitrophenylcarbonate in chloroform containing 1% methanol is catalyzed with turnover by ditopic receptors 1 and 2, consisting of a calix[6]arene connected to a bicyclic guanidinium by means of a short spacer. The calix[6]arene subunit strongly binds to the trimethylammonium head group through cation-pi interactions ...
CUEVAS F. +5 more
openaire +3 more sources
Breathing Without Acetylcholinesterase
2004Acetylcholine (ACh) mediates neurotransmission at the neuromuscular junction and is involved in respiratory control1, notably chemosensitivity2 of central and peripheral origin. The level of ACh at the synaptic cleft and neuromuscular junction is regulated by the enzyme acetylcholinesterase (AChE).
Chatonnet, Fabrice +4 more
openaire +4 more sources
Acetylcholinesterase in the human retina
Brain Research, 1987The distribution of cholinesterase activity in the human retina was evaluated using histochemical methods. The butyrylcholine esterase (BuChE) inhibitor tetraisopropylpyrophosphoramide was used to localize acetylcholinesterase (AChE) activity, the AChE inhibitor BW284c51 was used to localize BuChE activity, and eserine was used to inhibit all ...
J B, Hutchins, J G, Hollyfield
openaire +2 more sources
Stereospecificity of erythrocyte acetylcholinesterase
Archives of Biochemistry and Biophysics, 1964Abstract Lactoylcholine is a choline ester which contains an asymmetric carbon atom in the acid portion of the molecule. A study of the hydrolytic rate of the enantiomers of this choline ester by human erythrocyte acetylcholinesterase revealed that the l (+) isomer is hydrolyzed at least four times greater than the d (−) isomer.
J V, AUDITORE, B V, SASTRY
openaire +2 more sources