Results 11 to 20 of about 172,996 (401)

Recent developments in structural studies on acetylcholinesterase

Journal of Neurochemistry, 2017
Joel L Sussman
exaly   +2 more sources

Acetylcholinesterase Inhibitors in the Treatment of Neurodegenerative Diseases and the Role of Acetylcholinesterase in their Pathogenesis

International Journal of Molecular Sciences, 2021
Acetylcholinesterase (AChE) plays an important role in the pathogenesis of neurodegenerative diseases by influencing the inflammatory response, apoptosis, oxidative stress and aggregation of pathological proteins. There is a search for new compounds that
Łucja Justyna Walczak-Nowicka, Mariola Herbet   +1 more
semanticscholar   +1 more source

Readthrough acetylcholinesterase is increased in human liver cirrhosis. [PDF]

PLoS ONE, 2012
BACKGROUND & AIMS: There have been many studies on plasma butyrylcholinesterase in liver dysfunction. However, no data is available about acetylcholinesterase in human cirrhosis, although profound changes have been described in cirrhotic rat models ...
María-Salud García-Ayllón, Cristina Millán, Carol Serra-Basante, Ramón Bataller, Javier Sáez-Valero   +4 more
doaj   +1 more source

The State of The Art on Acetylcholinesterase Inhibitors in the Treatment of Alzheimer’s Disease

Journal of Central Nervous System Disease, 2021
Alzheimer’s disease (AD) is a chronic disabling disease that affects the central nervous system. The main consequences of AD include the decline of cognitive functions and language disorders.
I. Vecchio, L. Sorrentino, Annamaria Paoletti, R. Marra, M. Arbitrio   +4 more
semanticscholar   +1 more source

Application of HPLC-DAD for In Vitro Investigation of Acetylcholinesterase Inhibition Activity of Selected Isoquinoline Alkaloids from Sanguinaria canadensis Extracts

Molecules, 2021
Isoquinoline alkaloids may have a wide range of pharmacological activities. Some of them have acetylcholinesterase activity inhibition. Nowadays, neurodegenerative disorders such as Alzheimer’s disease have become a serious public health problem ...
Tomasz Tuzimski, Anna Petruczynik
doaj   +1 more source

Revealing the Acetylcholinesterase Inhibitory Potential of and Its Phytoconstituents: In Vitro and in Silico Approach

Bioinformatics and Biology Insights, 2022
The inhibition of acetylcholinesterase plays a vital role in the treatment of Alzheimer disease. This study aimed to explore the acetylcholinesterase inhibition potential of Phyllanthus amarus and its phytoconstituents through an in vitro and in silico ...
Kolade O Faloye, Shafi Mahmud, Emmanuel G Fakola, Yemisi M Oyetunde, Sunday J Fajobi, Jeremiah P Ugwo, Ayobami J Olusola, Samson O Famuyiwa, Oluwabukunmi G Olajubutu, Temitope I Oguntade, Ahmad J Obaidullah   +10 more
doaj   +1 more source

Structure-Based Design and Molecular Dynamics Simulations of Pentapeptide AEYTR as a Potential Acetylcholinesterase Inhibitor

Indonesian Journal of Chemistry, 2020
Structure-based virtual screening protocol to identify potent acetylcholinesterase inhibitors was retrospectively validated. The protocol could be employed to examine the potential of designed compounds as novel acetylcholinesterase inhibitors.
Vivitri Dewi Prasasty, Enade Perdana Istyastono   +1 more
doaj   +1 more source

Adverse Effects of Cholinesterase Inhibitors in Dementia, According to the Pharmacovigilance Databases of the United-States and Canada. [PDF]

, 2015
This survey analyzes two national pharmacovigilance databases in order to determine the major adverse reactions observed with the use of cholinesterase inhibitors in dementia.
Abagyan, Ruben, Ali, Thibault B, Chen, Winston Yuchen, Reilly, Brian M, Schleret, Thomas R   +4 more
core   +10 more sources

Biologically Potent Benzimidazole-Based-Substituted Benzaldehyde Derivatives as Potent Inhibitors for Alzheimer’s Disease along with Molecular Docking Study

Pharmaceuticals, 2023
Twenty-one analogs were synthesized based on benzimidazole, incorporating a substituted benzaldehyde moiety (1–21). These were then screened for their acetylcholinesterase and butyrylcholinesterase inhibition profiles.
Bushra Adalat, Fazal Rahim, Wajid Rehman, Zarshad Ali, Liaqat Rasheed, Yousaf Khan, Thoraya A. Farghaly, Sulaiman Shams, Muhammad Taha, Abdul Wadood, Syed A. A. Shah, Magda H. Abdellatif   +11 more
doaj   +1 more source

Acetylcholinesterase Involvement in Apoptosis [PDF]

Frontiers in Molecular Neuroscience, 2012
To date, more than 40 different types of cells from primary cultures or cell lines have shown AChE expression during apoptosis and after the induction apoptosis by different stimuli. It has been well-established that increased AChE expression or activity is detected in apoptotic cells after apoptotic stimuli in vitro and in vivo, and AChE could be ...
Xuejun Zhang, David S. Greenberg
openaire   +4 more sources