Results 21 to 30 of about 67,911 (287)

Acetylcholinesterase: The “Hub” for Neurodegenerative Diseases and Chemical Weapons Convention

Biomolecules, 2020
This article describes acetylcholinesterase (AChE), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by Alzheimer’s disease, or as a warfare ...
Samir F. de A. Cavalcante, Alessandro B. C. Simas, Marcos C. Barcellos, Victor G. M. de Oliveira, Roberto B. Sousa, Paulo A. de M. Cabral, Kamil Kuča, Tanos C. C. França   +7 more
doaj   +1 more source

Insecticidal Terpenes From the Essential Oils of Artemisia nakaii and Their Inhibitory Effects on Acetylcholinesterase

Frontiers in Plant Science, 2021
Essential oils (EOs) are often the source of insecticidal substances of high efficiency and low toxicity. From gas chromatograph-mass spectrometer, column chromatography, and nuclear magnetic resonance spectra analyses, twenty terpenes were identified ...
Jiayi Liu, Juan Hua, Juan Hua, Bo Qu, Bo Qu, Xuanyue Guo, Yangyang Wang, Meini Shao, Shihong Luo, Shihong Luo   +9 more
doaj   +1 more source

Searching for potential acetylcholinesterase inhibitors: a combined approach of multi-step similarity search, machine learning and molecular dynamics simulations

Royal Society Open Science
Targeting acetylcholinesterase is one of the most important strategies for developing therapeutics against Alzheimer’s disease. In this work, we have employed a new approach that combines machine learning models, a multi-step similarity search of the ...
Quynh Mai Thai, Minh Quan Pham, Phuong-Thao Tran, Trung Hai Nguyen, Son Tung Ngo   +4 more
doaj   +1 more source

Organophosphorus insecticides: Toxic effects and bioanalytical tests for evaluating toxicity during degradation processes [PDF]

Hemijska Industrija, 2013
Organophosphorus insecticides have been the most applied group of insecticides for the last two decades. Their main toxic effects are related to irreversible inactivation of acetylcholinesterase (AChE).
Čolović Mirjana B., Krstić Danijela Z., Vasić Vesna M., Bondžić Aleksandra M., Ušćumlić Gordana S., Petrović Slobodan D.   +5 more
doaj   +1 more source

Acetylcholinesterase in Thrombocytes [PDF]

Nature, 1952
IT has been shown recently1 that the thrombocytes of rat blood contain a cholinesterase having properties similar to the acetylcholinesterase found in erythrocytes. The present communication gives evidence for the presence of an acetylcholinesterase in the thrombocytes of other animals.
K B, AUGUSTINSSON, N, DATTA, M, GRAHN, J, ZAJICEK   +3 more
openaire   +2 more sources

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub‐Quantal Exocytosis in Living Neurons and Organoids

Angewandte Chemie, EarlyView.
Schematic representation of M@E@CF nanosensors for detecting vesicular storage and release in cholinergic neurons and brain organoids. (A) Nano‐tip microelectrodes modification via molds fabricated through 3D printing. (B) the reaction mechanism for acetylcholine detection at the electrode interface.
Wanying Zhu, Yufan Zhang, Hanwen Yu, Da Wang, Xinyue Zhang, Xiaowen Du, Shanshan Wu, Bingzhi Li, Yizhou Zhang, Hongliang Xin, Xing Guo, Yan Liu   +11 more
wiley   +2 more sources

Multifunctional Donepezil Analogues as Cholinesterase and BACE1 Inhibitors

Molecules, 2018
A series of 22 donepezil analogues were synthesized through alkylation/benzylation and compared to donepezil and its 6-O-desmethyl adduct. All the compounds were found to be potent inhibitors of both acetylcholinesterase (AChE) and butyrylcholinesterase (
Keith D. Green, Marina Y. Fosso, Sylvie Garneau-Tsodikova   +2 more
doaj   +1 more source

Will Memantine Exacerbate Seizures in People With Epilepsy? A Prospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate whether add‐on memantine would exacerbate seizures in people with epilepsy. Methods This was a prospective cohort study. People with epilepsy diagnosed with cognitive impairment were consecutively invited. Those who agreed were followed up for at least 24 weeks.
Peiyu Wang, Lu Lu, Hui Gao, Qi Zhang, Jing Xiao, Josemir W. Sander, Weixi Xiong, Dong Zhou   +7 more
wiley   +1 more source

Divergent Total Synthesis of Denudatine Alkaloids Cochlearenine, Macrocentrine, Dictizine, 15‐Veratroyl‐17‐Acetyl‐19‐Oxodictizine, and the Proposed Structure of Acochlearine

Angewandte Chemie, EarlyView.
An intramolecular Mannich reaction (A/B/E/F rings) and intermolecular Diels–Alder reactions (C/D rings) afforded a cage‐like hexacyclic core skeleton of denudatine alkaloids. Derivatization of the hexacyclic intermediate enabled the first asymmetric total syntheses of four denudatine alkaloids: (–)‐cochlearenine, (–)‐macrocentrine, (–)‐dictizine, and (–
Shun Kawano, Naoya Miyamoto, Kosuke Fujioka, Hiroki Toya, Juri Sakata, Hidetoshi Tokuyama   +5 more
wiley   +2 more sources