Results 31 to 40 of about 64,125 (299)

Acetylcholinesterase inhibitors for schizophrenia [PDF]

European Psychiatry, 2009
IntroductionAs evidenced by ongoing research and partial effectiveness of the antipsychotics on cognitive and negative symptoms, the search is on for drugs that may improve these domains of functioning for someone suffering from schizophrenia.ObjectivesTo do a sytematic review to find out if acetylcholinesterase inhibitors could be used for ...
Jasvinder A. Singh, Kamalpreet Kour, Mahesh Jayaram   +2 more
openaire   +4 more sources

Synthesis, characterisation, biological evaluation and in silico studies of sulphonamide Schiff bases

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
Sulphonamides are biologically important compounds with low toxicity, many bioactivities and cost-effectiveness. Eight sulphonamide derivatives were synthesised and characterised by FT-IR, 13C NMR, 1H NMR, LC-MS and elemental analysis.
Mustafa Durgun, Cüneyt Türkeş, Mesut Işık, Yeliz Demir, Ali Saklı, Ali Kuru, Abdussamat Güzel, Şükrü Beydemir, Suleyman Akocak, Sameh M. Osman, Zeid AlOthman, Claudiu T. Supuran   +11 more
doaj   +1 more source

Variation in Drosophila acetylcholinesterase

Biochemical Genetics, 1980
We examined the Canton-S strain of Drosophila melanogaster for electrophoretic variation of the enzyme acetylcholinesterase. The pattern of bands obtained (stained with acetylthiocholine) depended on age, sex, and tissue (i.e., head vs. body part and hemolymph).
Richard A. Morton, Rama S. Singh
openaire   +3 more sources

The Effect of Parathion on Red Blood Cell Acetylcholinesterase in the Wistar Rat

Journal of Toxicology, 2016
Organophosphorus (OP) pesticide poisoning is a significant problem worldwide. Research into new antidotes for these acetylcholinesterase inhibitors, and even optimal doses for current therapies, is hindered by a lack of standardized animal models.
Naofumi Bunya, Keigo Sawamoto, Hanif Benoit, Steven B. Bird   +3 more
doaj   +1 more source

Acetylcholinesterase inhibitory activity of sesquiterpenoids isolated from Laggera pterodonta

Frontiers in Plant Science, 2023
Plant-derived natural products are important resources for pesticide discovery. Acetylcholinesterase (AChE) is a well-validated pesticide target, and inhibiting AChE proves fatal for insects.
Jinliang Li, Jinliang Li, Fengchao Li, Guoxing Wu, Furong Gui, Hongmei Li, Lili Xu, Xiaojiang Hao, Yuhan Zhao, Xiao Ding, Xiaoping Qin   +10 more
doaj   +1 more source

Bacopa monnieri: A promising herbal approach for neurodegenerative disease treatment supported by in silico and in vitro research

Heliyon, 2023
Neurodegenerative disorders, caused by progressive neuron loss, are a global health issue. Among the various factors implicated in their pathogenesis, dysregulation of acetylcholinesterase activity has been recognized as a key contributor ...
Shehla Shoukat, Muhammad Amir Zia, Muhammad Uzair, Kotb A. Attia, Asmaa M. Abushady, Sajid Fiaz, Shaukat Ali, Seung Hwan Yang, Ghulam Muhammad Ali   +8 more
doaj  

Searching for potential acetylcholinesterase inhibitors: a combined approach of multi-step similarity search, machine learning and molecular dynamics simulations

Royal Society Open Science
Targeting acetylcholinesterase is one of the most important strategies for developing therapeutics against Alzheimer’s disease. In this work, we have employed a new approach that combines machine learning models, a multi-step similarity search of the ...
Quynh Mai Thai, Minh Quan Pham, Phuong-Thao Tran, Trung Hai Nguyen, Son Tung Ngo   +4 more
doaj   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations

Advanced Functional Materials, EarlyView.
Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan, Simona Summonte, Fabrizio Ricci, Matthias Sandmeier, Andreas Bernkop‐Schnürch   +4 more
wiley   +1 more source

A rapid in vitro assay for evaluating the effects of acetylcholinesterase inhibitors and reactivators in the rat basolateral amygdala

Frontiers in Cellular Neuroscience, 2022
We established a novel brain slice assay to test the ability of acetylcholinesterase (AChE) reactivators to prevent ACh-induced M1 muscarinic acetylcholine receptor (mAChR) dependent hyperexcitability observed after exposure to the organophosphate (OP ...
Jeffrey S. Thinschmidt, Scott W. Harden, Michael A. King, James D. Talton, Charles J. Frazier   +4 more
doaj   +1 more source