Results 31 to 40 of about 125,133 (347)

A Comparison of the Potency of the Oxime HLö-7 and Currently Used Oximes (HI-6, Pralidoxime, Obidoxime) to Reactivate Nerve Agent-Inhibited Rat Brain Acetylcholinesterase by in vitro Methods

open access: yesActa Medica, 2005
1. The efficacy of the oxime HLö-7 and currently used oximes (pralidoxime, obidoxime, HI-6) to reactivate acetylcholinesterase inhibited by various nerve agents (sarin, tabun, cyclosarin, VX) was tested by in vitro methods. 2. Both H oximes (HLö-7, HI-6)
Kamil Kuča   +4 more
doaj   +1 more source

AChE-activity in critically ill patients with suspected septic encephalopathy: a prospective, single-centre study

open access: yesBMC Anesthesiology, 2020
Background Up to 70% of septic patients develop a diffuse brain dysfunction named “septic associated encephalopathy” which is often solely based on clinical impressions.
Benedikt Zujalovic   +4 more
doaj   +1 more source

Acetylcholinesterase, as a potential biomarker of naphthalene toxicity in different tissues of freshwater teleost, Anabas testudineus

open access: yesJournal of Environmental Engineering and Landscape Management, 2021
Naphthalene, a Polycyclic Aromatic Hydrocarbon is widely used as a fumigant and disinfectant despite its toxic effect and is ranked as the ninth most threatening compound.
Susri Nayak, Lipika Patnaik
doaj   +1 more source

A network model to investigate structural and electrical properties of proteins [PDF]

open access: yesNanotechnology, 19, 065202 (2008), 2007
One of the main trend in to date research and development is the miniaturization of electronic devices. In this perspective, integrated nanodevices based on proteins or biomolecules are attracting a major interest. In fact, it has been shown that proteins like bacteriorhodopsin and azurin, manifest electrical properties which are promising for the ...
arxiv   +1 more source

Involvement of acetylcholinesterase inhibition in paralyzing effects of monocrotophos in Caenorhabditis elegans

open access: yesJournal of Basic and Applied Zoology, 2018
Background Organophosphorus insecticides (OPI) are among the most commonly used class of pesticides in agricultural and domestic scenarios. Clinical presentations of acute OPI toxicity are attributable to acetylcholinesterase inhibition and ensuing ...
Apurva Kumar Ramesh Joshi   +2 more
doaj   +1 more source

Enhanced diffusion and enzyme dissociation [PDF]

open access: yesJournal of the American Chemical Society 2019, 2019
The concept that catalytic enzymes can act as molecular machines transducing chemical activity into motion has conceptual and experimental support, but much of the claimed support comes from experimental conditions where the substrate concentration is higher than biologically relevant and accordingly exceeds kM, the Michaelis-Menten constant. Moreover,
arxiv   +1 more source

Butyrylcholinesterase and Acetylcholinesterase polymorphisms in Multiple Sclerosis patients: Implication in peripheral inflammation [PDF]

open access: yes, 2018
Multiple Sclerosis (MS) is an autoimmune disease, having not fully understood aetiology, and both genetic and environmental factors contribute to the pathogenesis of the disease.
Costantini, Erica   +13 more
core   +2 more sources

Master curve of boosted diffusion for ten catalytic enzymes [PDF]

open access: yes, 2020
Molecular agitation more rapid than thermal Brownian motion is reported for cellular environments, motor proteins, synthetic molecular motors, enzymes, and common chemical reactions, yet that chemical activity couples to molecular motion contrasts with generations of accumulated knowledge about diffusion at equilibrium. To test the limits of this idea,
arxiv   +1 more source

Mining electron density for functionally relevant protein polysterism in crystal structures. [PDF]

open access: yes, 2010
This review focuses on conceptual and methodological advances in our understanding and characterization of the conformational heterogeneity of proteins.
Fraser, James S, Jackson, Colin J
core   +3 more sources

Acetylcholinesterase inhibitors for schizophrenia [PDF]

open access: yesEuropean Psychiatry, 2009
IntroductionAs evidenced by ongoing research and partial effectiveness of the antipsychotics on cognitive and negative symptoms, the search is on for drugs that may improve these domains of functioning for someone suffering from schizophrenia.ObjectivesTo do a sytematic review to find out if acetylcholinesterase inhibitors could be used for ...
Jasvinder A. Singh   +2 more
openaire   +4 more sources

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