Results 171 to 180 of about 2,693 (199)

The pea seedling mitochondrial Nε-lysine acetylome

Mitochondrion, 2014
Posttranslational lysine acetylation is believed to occur in all taxa and to affect thousands of proteins. In contrast to the hundreds of mitochondrial proteins reported to be lysine-acetylated in non-plant species, only a handful have been reported from the plant taxa previously examined. To investigate whether this reflects a biologically significant
Colin L, Smith-Hammond, Elizabeth, Hoyos, Ján A, Miernyk   +2 more
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An integrated perspective and functional impact of the mitochondrial acetylome

Expert Review of Proteomics, 2014
Growing evidence suggests that a range of reversible protein post-translational modifications such as acetylation regulates mitochondria signalling, impacting cellular homeostasis. However, the extent of this type of regulation in the control of mitochondria functionality is just beginning to be discovered, aided by the availability of high-resolution ...
Francisco M, Amado, António, Barros, Ana Lúcia, Azevedo, Rui, Vitorino, Rita, Ferreira   +4 more
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Obesity‐Mediated Regulation of the Cardiac Acetylome

The FASEB Journal, 2017
Lysine residues undergo diverse and reversible post‐translational modifications that include acetylation, ubiquitylation and methylation. Lysine acetylation has traditionally been studied in the regulation of gene expression, where acetylation of histone tails alters electrostatic interactions of nucleosomal DNA.
Samantha S Romanick, Andrew Hostler, Karen Schlauch, David Quilici, Yumei Feng, Bradley Ferguson   +5 more
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Comprehensive lysine acetylomes emerging from bacteria to humans

Trends in Biochemical Sciences, 2011
Recent proteomic studies reveal that 5-10% of mammalian and bacterial proteins undergo lysine acetylation, a post-translational modification that adds an acetyl group to the ɛ-amino group of lysine residues. Many of these proteins are not canonical targets, such as histones and transcription factors, suggesting that this modification plays a much wider
Go-Woon, Kim, Xiang-Jiao, Yang
openaire   +2 more sources

Systematic Analysis of the Lysine Acetylome in Candida albicans

Journal of Proteome Research, 2016
Candida albicans (C. albicans) is a worldwide cause of fungal infectious diseases. As a general post-translational modification (PTM), lysine acetylation of proteins play an important regulatory role in almost every cell. In our research, we used a high-resolution proteomic technique (LC-MS/MS) to present the comprehensive analysis of the acetylome in ...
Xiaowei, Zhou, Guanyu, Qian, Xingling, Yi, Xiaofang, Li, Weida, Liu   +4 more
openaire   +2 more sources

Systematic Analysis of the Lysine Acetylome in Vibrio parahemolyticus

Journal of Proteome Research, 2014
Lysine acetylation of proteins is a major post-translational modification that plays an important regulatory role in almost every aspect of cells, both eukaryotes and prokaryotes. Vibrio parahemolyticus, a model marine bacterium, is a worldwide cause of bacterial seafood-borne illness.
Jianyi, Pan, Zhicang, Ye, Zhongyi, Cheng, Xiaojun, Peng, Liangyou, Wen, Fukun, Zhao   +5 more
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Prokaryotic Nε‐lysine acetylomes and implications for new antibiotics

Journal of Cellular Biochemistry, 2012
AbstractProtein Nε‐acetylation, a post‐translational modification widespread in eukaryotes and prokaryotes, has been intensively explored due to its crucial roles in multitudinous physiologic events including transcriptional regulation, metabolic regulation, etc.
Longxiang, Xie, Wu, Li, Jianping, Xie
openaire   +2 more sources

Automated Immunoprecipitation Workflow for Comprehensive Acetylome Analysis

Immunoprecipitation is one of the most effective methods for enrichment of lysine-acetylated peptides for comprehensive acetylome analysis using mass spectrometry. Manual acetyl peptide enrichment method using non-conjugated antibodies and agarose beads has been developed and applied in various studies.
Marina A, Gritsenko, Chia-Feng, Tsai, Hyeyoon, Kim, Tao, Liu   +3 more
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SILAC-Based Quantification of Sirt1-Responsive Lysine Acetylome

2013
Stable Isotope Labeling by Amino acids in Cell culture (SILAC) is one of the in vivo metabolic labeling methods widely used for dynamic analysis of protein modifications. Here, we describe a general approach to applying SILAC, in combination with affinity enrichment of acetyllysine peptides and mass spectrometry, to study the dynamic changes of the ...
Yue, Chen, Gozde, Colak, Yingming, Zhao
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Comprehensive profiling of lysine acetylome in Staphylococcus aureus

Science China Chemistry, 2014
The Gram-positive bacterium Staphylococcus aureus (S. aureus) is a wide spread common opportunistic pathogen that causes a wide variety of infectious diseases, from benign skin infections to life-threatening diseases such as the methicillin-resistant Staphylococcus aureus (MRSA) infection. Although emerging evidence suggests that lysine acetylation may
Yi Zhang, ZhiXiang Wu, XueLian Wan, Ping Liu, JiBao Zhang, Yang Ye, YingMing Zhao, MinJia Tan   +7 more
openaire   +1 more source