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Peptides inhibitors of acid-sensing ion channels
Toxicon, 2007Acid-sensing ion channels (ASICs) channels are proton-gated cationic channels mainly expressed in central and peripheric nervous system and related to the epithelial amiloride-sensitive Na(+) channels and to the degenerin family of ion channels. ASICs comprise four proteins forming functional channel subunits (ASIC1a, ASIC1b, ASIC2a, and ASIC3) and two
Diochot, S. +4 more
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Biophysical properties of acid-sensing ion channels (ASICs)
Neuropharmacology, 2015Acid-sensing ion channels (ASICs) are ligand-gated ion channels that are exquisitely sensitive to extracellular protons and can sense transient as well as sustained acidification. In this review, we will discuss activation and desensitization of ASICs by protons.
Grunder S, Pusch M
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Genetic exploration of the role of acid-sensing ion channels
Neuropharmacology, 2015Advanced gene targeting technology and related tools in mice have been incorporated into studies of acid-sensing ion channels (ASICs). A single ASIC subtype can be knocked out specifically and screened thoroughly for expression in the nervous system at the cellular level.
Shing-Hong, Lin +2 more
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Potentiation of acid-sensing ion channels by sulfhydryl compounds
American Journal of Physiology-Cell Physiology, 2007The acid-sensing ion channels (ASICs) are voltage-independent ion channels activated by acidic extracellular pH. ASICs play a role in sensory transduction, behavior, and acidotoxic neuronal death, which occurs during stroke and ischemia. During these conditions, the extracellular concentration of sulfhydryl reducing agents increases.
Jun-Hyeong, Cho, Candice C, Askwith
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Targeting Acid-Sensing Ion Channels in Disease
Acidosis is a central feature of many pathological conditions, and while the activity of many ion channels is suppressed under acidic conditions, acid-sensing ion channels (ASICs) are exquisitely sensitive to decreases in pH and activated by protons. The expression and function of ASICs is enhanced under conditions of ischemia, inflammation, and trauma.Senescall, Victor +9 more
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Acid‐sensing ion channels in allergic rhinitis
Clinical & Experimental Allergy, 2012openaire +3 more sources
Pharmacology of acid-sensing ion channels – Physiological and therapeutical perspectives
Neuropharmacology, 2015Anne Baron, Eric Lingueglia
exaly