Results 241 to 250 of about 40,009 (268)
Acid-sensing ion channels in gastrointestinal function
Neuropharmacology, 2015 Gastric acid is of paramount importance for digestion and protection from pathogens but, at the same time, is a threat to the integrity of the mucosa in the upper gastrointestinal tract and may give rise to pain if inflammation or ulceration ensues.
Peter Holzer
exaly +4 more sources
Pharmacology of acid-sensing ion channels – Physiological and therapeutical perspectives
Neuropharmacology, 2015 International audienceDevelopment of the pharmacology of Acid-Sensing Ion Channels (ASICs) has become a key challenge to study their structure, their molecular and cellular functions and their physiopathological roles.
Anne Baron, Eric Lingueglia
exaly +3 more sources
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2020
Abstract Acid-sensing ion channels (ASICs) are proton-gated Na+ channels. Being almost ubiquitously present in neurons of the vertebrate nervous system, their precise function remained obscure for a long time. Various animal toxins that bind to ASICs with high affinity and specificity have been tremendously helpful in uncovering the role
Silke Haerteis, Stephan Kellenberger
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Abstract Acid-sensing ion channels (ASICs) are proton-gated Na+ channels. Being almost ubiquitously present in neurons of the vertebrate nervous system, their precise function remained obscure for a long time. Various animal toxins that bind to ASICs with high affinity and specificity have been tremendously helpful in uncovering the role
Silke Haerteis, Stephan Kellenberger
openaire +2 more sources
Acid-sensing ion channels and their modulators
Biochemistry (Moscow), 2014According to a modern look acid-sensing ion channels (ASICs) are one of the most important receptors that perceive pH change in the body. ASICs represent proton-gated Na+-selective channels, which are expressed in neurons of the central and peripheral nervous system.
D I, Osmakov, Ya A, Andreev, S A, Kozlov
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Acid Sensing Ion Channels and Acid Nociception
Current Pharmaceutical Design, 2009Acid Sensing Ion Channels (ASICs) are a family of cation channels expressed principally in neurons and that are activated by protons. The sensitivity of ASICs to acidosis and their distribution in primary sensory neurons points to a significant role of these channels in acid nociception. However, despite the fact that the first ASIC was identified more
G R, Dubé, A, Elagoz, H, Mangat
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Acid-sensing ion channels in pain and disease [PDF]
Nature Reviews Neuroscience, 2013 Why do neurons sense extracellular acid? In large part, this question has driven increasing investigation on acid-sensing ion channels (ASICs) in the CNS and the peripheral nervous system for the past two decades. Significant progress has been made in understanding the structure and function of ASICs at the molecular level.
John A Wemmie +2 more
exaly +3 more sources
Identification of acid-sensing ion channels in bone
Biochemical and Biophysical Research Communications, 2005Bone balances serum pH variations and both osteoclasts and osteoblasts are regulated by subtle changes in pH. The aim of the current study was to identify molecules in bone that can sense pH. Interesting candidates are the acid-sensing ion channels (ASICs). In bone, ASIC2 and ASIC3 were most abundant, while in chondrocytes it was ASIC1.
Jahr, Holger +4 more
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Biophysical properties of acid-sensing ion channels (ASICs)
Neuropharmacology, 2015Acid-sensing ion channels (ASICs) are ligand-gated ion channels that are exquisitely sensitive to extracellular protons and can sense transient as well as sustained acidification. In this review, we will discuss activation and desensitization of ASICs by protons.
Grunder S, Pusch M
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Genetic exploration of the role of acid-sensing ion channels
Neuropharmacology, 2015Advanced gene targeting technology and related tools in mice have been incorporated into studies of acid-sensing ion channels (ASICs). A single ASIC subtype can be knocked out specifically and screened thoroughly for expression in the nervous system at the cellular level.
Shing-Hong, Lin +2 more
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Potentiation of acid-sensing ion channels by sulfhydryl compounds
American Journal of Physiology-Cell Physiology, 2007The acid-sensing ion channels (ASICs) are voltage-independent ion channels activated by acidic extracellular pH. ASICs play a role in sensory transduction, behavior, and acidotoxic neuronal death, which occurs during stroke and ischemia. During these conditions, the extracellular concentration of sulfhydryl reducing agents increases.
Jun-Hyeong, Cho, Candice C, Askwith
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