Results 81 to 90 of about 9,968 (290)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Resumen del trabajo presentado al 38th International Specialized Symposium on Yeasts, celebrado del 1 la 5 de septiembre de 2025 en Warsaw, Poland.Acetic acid and trehalose are key metabolites in Saccharomyces cerevisiae, significantly impacting wine ...
Aranda, Agustín +2 more
core +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
, 2003 The widespread sowing of the perennial forage legume Medicago sativa to lower groundwater tables in south-western Australia is limited as many soils targeted for its use are too acidic (pHCaCl2 < 5) for consistent nodulation with Sinorhizobium spp.
Cheng, Yvonne
core
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Regulation of bile acid receptor activity
Liver Research, 2018 Many receptors can be activated by bile acids (BAs) and their derivatives. These include nuclear receptors farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR), as well as membrane receptors Takeda G protein receptor 5 (TGR5), sphingosine-1-phosphate receptor 2 (S1PR2), and cholinergic receptor muscarinic 2 (CHRM2).
Wan, Yu-Jui Yvonne, Sheng, Lili
openaire +6 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Bile Acids: Major Regulator of the Gut Microbiome
, 2022 Bile acids are synthesized from cholesterol and play an important role in regulating intestinal microflora. The different degrees of hydrophobicity and acidity of individual bile acids may affect their antimicrobial properties.
Miil Kang +29 more
core +1 more source
FEBS Letters, EarlyView.The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber +7 more
wiley +1 more source
Midgut Acidity Regulates Metabolism and Lifespan in Drosophila melanogaster and Mice
, 2017 老化與代謝症候群是當代醫學的重要課題，近年來果蠅廣被應用於這些問題的基礎研究。在先前的研究中，我們透過突變株篩選，發現消化道中酸分泌缺失的果蠅會出現類似代謝症候群的表現型(肥胖及高三酸甘油酯)，且其壽命顯著縮短，顯示消化道酸鹼度可能影響老化與代謝過程。 為延續上述成果，本計畫繼續透過基因操弄與藥物介入等方式，建立消化道中段酸分泌異常的果蠅模式，進而系統性的探討消化道中段酸分泌不足對於老化與代謝的影響。在代謝表現型方面，我們發現腸道中段酸度不足的果蠅有體脂肪含量與體重上升，與飢餓耐受度增加等現象 ...
林為聖, Lin, Wei-Sheng
core