Metformin-Associated Lactic Acidosis [PDF]
Introduction Metformin is a first line oral medication for diabetes mellitus shown to decrease cardiovascular morbidity and mortality. Though the prevalence of metformin-associated lactic acidosis (MALA) is low, mortality is high, ranging from 25-50 ...
Sunghwan Suh
doaj +4 more sources
Severe Metformin-Associated Lactic Acidosis-A Case Report. [PDF]
ABSTRACT Metformin, a widely prescribed and generally safe drug for diabetes mellitus, can rarely lead to metformin‐associated lactic acidosis—a severe, potentially fatal complication. Early recognition, emergency hemodialysis, and supportive management are crucial for favorable outcomes, highlighting the importance of prompt diagnosis and intervention
Artinyan E +7 more
europepmc +2 more sources
Metformin, Sulfonylureas, or Other Antidiabetes Drugs and the Risk of Lactic Acidosis or Hypoglycemia [PDF]
OBJECTIVE: Lactic acidosis has been associated with use of metformin. Hypoglycemia is a major concern using sulfonylureas. The aim of this study was to compare the risk of lactic acidosis and hypoglycemia among patients with type 2 diabetes using oral ...
Bodmer, Michael +4 more
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Severe drug-induced liver injury associated with prolonged use of Linezolid [PDF]
This study aims to describe a patient developing concomitant severe liver failure and lactic acidosis after long-term treatment with linezolid. A 55-year-old Caucasian woman developed concomitant severe liver failure and lactic acidosis after a treatment
Benoit, Dominique +7 more
core +1 more source
Type B Lactic Acidosis in a Patient with Mantle Cell Lymphoma
Type B lactic acidosis is an uncommon medical emergency in which acid production overwhelms hepatic clearance. This specific etiology of lactic acidosis occurs without organ hypoperfusion and has been most commonly described in patients with hematologic ...
Ikemsinachi C. Nzenwa +12 more
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Point-of-care measurement of blood lactate in children admitted with febrile illness to an African District Hospital. [PDF]
BACKGROUND: Lactic acidosis is a consistent predictor of mortality owing to severe infectious disease, but its detection in low-income settings is limited to the clinical sign of "deep breathing" because of the lack of accessible technology for its ...
Acierno +22 more
core +1 more source
Oral health in two heterozygote female twins with congenital lactic acidosis [PDF]
Introduction: Congenital lactic acidosis (CLA) is a rare disease caused by mutations in Mithocondrial DNA (mtDNA), which affects the ability of cells to use energy that causes accumulation of lactic acid in the body.
GUERRA, Fabrizio +4 more
core +1 more source
Background Metformin has been widely used as a first-line agent to treat type 2 diabetes mellitus. Lactic acidosis is a rare but serious adverse effect in patients treated with metformin.
Hiroki Kinoshita +4 more
doaj +1 more source
Severe Lactic Acidosis in a Patient with B-Cell Lymphoma: A Case Report and Review of the Literature
Lactic acidosis is commonly observed in clinical situations such as shock and sepsis, as a result of tissue hypoperfusion and hypoxia. Lymphoma and leukemia are among other clinical situations where lactic acidosis has been reported. We present a case of
Farn Huei Chan +2 more
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Type B lactic acidosis associated with diffuse large B-cell lymphoma and the Warburg effect
Type B lactic acidosis is a rare complication of non-tissue perfusion abnormalities caused by solid tumors or hematologic malignancies. Herein, we present the case of a 42-year-old man with type B lactic acidosis and hypoglycemia who was found to have a ...
Chunhua Wang, Zanmei Lv, Yanwei Zhang
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