Results 121 to 130 of about 3,165 (181)
Roxadustat Attenuates Adverse Remodeling Following Myocardial Infarction in Mice
CellsActivation of the CXCL12/CXCR4/ACKR3 axis is known to aid myocardial repair through ischemia-triggered hypoxia-inducible factor-1α (HIF-1α). To enhance the upregulation of HIF-1α, we administered roxadustat, a novel prolyl hydroxylase inhibitor (PHI ...
Marc-Michael Zaruba +10 more
doaj +1 more source
The Role of C-X-C motif chemokine 12 in the crosstalk of brown adipocytes and microvascular endothelial cells [PDF]
The pandemic of obesity keeps on rising. Especially from a pharmacological point of view, treatment options are quite limited. Late research has shown that brown adipose tissue might be a promising target for the development of innovative therapeutic ...
Retiet, Max
core
ACKR3 in Skin Homeostasis, an Overlooked Player in the CXCR4/CXCL12 Axis
Journal of Investigative DermatologyCXCL12 and its receptor CXCR4 emerge as critical regulators within the intricate network of processes ensuring skin homeostasis. In this review, we discuss their spatial distribution and function in steady-state skin; delve into their role in acute wound healing, with emphasis on fibrotic and regenerative responses; and explore their relevance in skin ...
Gabriela, Cuesta-Margolles +2 more
openaire +2 more sources
Deficient GATA6-ACKR3/CXCR7 signaling leads to bicuspid aortic valve
AbstractThe cardiac outflow tract (OFT) transiently links the ventricles to the aortic sac and gives rise to the arterial valves. Abnormalities of the arterial valves, mainly bicuspid aortic valve (BAV), are the commonest congenital anomalies.Gata6inactivating mutations cause cardiac OFT defects and BAV, but the cellular and molecular mechanisms are ...
José Luis de la Pompa +2 more
openaire +1 more source
Subarachnoid hemorrhage alters CX43 and ACKR3 levels in cerebrospinal fluid: A preclinical study
Asian Journal of Surgery, 2023 Jian Yan +3 more
doaj +1 more source
G protein-coupled receptors (GPCRs) are a large family of cell-surface proteins involved in the transduction of a wide range of signals to initiate appropriate cellular response.
Pan, Kylie Shenglan
core +2 more sources
Specific GPCRs elicit unique extracellular vesicle miRNA array signatures. [PDF]
ElifeShi X +5 more
europepmc +1 more source
FTO-ACKR3 Axis Regulates Polycyclic Aromatic Hydrocarbons-Induced Asthma Attacks via AhR-Mediated m<sup>6</sup>A RNA Methylation. [PDF]
Environ Health (Wash)Liu S +6 more
europepmc +1 more source