Results 121 to 130 of about 3,455 (202)
Translational Oncology, 2015 Inflammatory breast cancer (IBC) is an aggressive and invasive tumor, accounting for 2.5% of all breast cancer cases, and characterized by rapid progression, regional and distant metastases, younger age of onset, and lower overall survival.
Roberto Wurth +6 more
doaj +1 more source
, 2020 Receptor activity-modifying proteins (RAMPs) interact with G-protein-coupled receptors (GPCRs) to modify their functions, imparting significant implications upon their physiological and therapeutic potentials.
Caron, Kathleen M +4 more
core +2 more sources
Advanced Science, Volume 12, Issue 30, August 14, 2025.RSPO2 and GDF9:BMP15 heterodimers—core components of oocyte‐secreted factors (OSFs)—coordinate to shape the molecular architecture of preantral granulosa cells via gene‐specific synergistic and antagonistic regulation, mediated through CTNNB1–SMAD2 signaling crosstalk.
Yingmei Wang +7 more
wiley +1 more source
Clinical and Translational Discovery, Volume 5, Issue 4, August 2025.Impaired antigen presentation function of B cells in patients with non‐complete response (NCR). CXCL13+ T cells are involved in the formation of tertiary lymphoid structures. POSTN+CAF recruit tumour‐associated macrophages and promote the formation of an immunosuppressive environment.
Xianxian Wu +8 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 29, Issue 15, August 2025.ABSTRACT Breast cancer (BRCA) is characterised by complex cellular heterogeneity and differentiation hierarchies, which play a crucial role in bone metastasis and therapeutic resistance. However, existing classification systems remain inadequate in capturing these complexities, limiting their effectiveness in guiding treatment strategies.
Penghui Yan +11 more
wiley +1 more source
The atypical receptor CCRL2 (C-C Chemokine Receptor-Like 2) does not act as a decoy receptor in endothelial cells [PDF]
, 2017 C-C chemokine receptor-like 2 (CCRL2) is a non-signaling seven-transmembrane domain (7-TMD) receptor related to the atypical chemokine receptor (ACKR) family.
Annalisa Del Prete +8 more
core +3 more sources
Decreased ACKR3 (CXCR7) function causes oculomotor synkinesis in mice and humans
Human Molecular Genetics, 2019 Abstract Oculomotor synkinesis is the involuntary movement of the eyes or eyelids with a voluntary attempt at a different movement. The chemokine receptor CXCR4 and its ligand CXCL12 regulate oculomotor nerve development; mice with loss of either molecule have oculomotor synkinesis.
Mary C, Whitman +11 more
openaire +3 more sources
Frontiers in Immunology, 2015 CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow and their recruitment to sites of injury, as well as affect processes such as cell arrest, survival and angiogenesis.
Lukas ePawig +4 more
doaj +1 more source
CXCL12 promotes the crossing of retinal ganglion cell axons at the optic chiasm [PDF]
Binocular vision requires the segregation of retinal ganglion cell (RGC) axons extending from the retina into the ipsilateral and contralateral optic tracts. RGC axon segregation occurs at the optic chiasm, which forms at the ventral diencephalon midline.
Denti, Laura +7 more
core +4 more sources
Targeting the Atypical Chemokine Receptor ACKR3/CXCR7 for the treatment of cancer and other diseases [PDF]
, 2015 One of the greatest challenges in fighting cancer is cell targeting and biomarker selection. The Atypical Chemokine Receptor ACKR3/CXCR7 is expressed on many cancer cell types, including breast cancer and glioblastoma, and binds the endogenous ligands ...
NC DOCKS at The University of North Carolina at Greensboro +1 more
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