Results 161 to 170 of about 2,928 (195)

BMP2 induces osteogenic differentiation through ACKR3 in mesenchymal stem cells

Biochemical and Biophysical Research Communications, 2023
In recent years, bone loss related diseases have attracted more and more attention, such as osteoporosis and osteonecrosis of the femoral head exhibited symptoms of osteopenia or insufficient bone mass in a certain stage.
Jiang-Wen Liu, Xin-Tong Yao, Xiaohui Feng, Xi-Zhuang Bai   +3 more
exaly   +4 more sources

ACKR3 orchestrates Hedgehog signaling to promote renal cell carcinoma progression

Molecular Carcinogenesis, 2023
Renal cell carcinoma (RCC) is the second commonest urological malignant neoplasm and mortality rate of patients with RCC appears to be increasing each year.
Chao Tang, Lin Li, Qiang Xu, Shouying Xu, Chao Lin, B. Cao   +5 more
exaly   +4 more sources

Endothelial ACKR3 drives atherosclerosis by promoting immune cell adhesion to vascular endothelium [PDF]

Basic Research in Cardiology, 2022
Atherosclerosis is the foundation of potentially fatal cardiovascular diseases and it is characterized by plaque formation in large arteries. Current treatments aimed at reducing atherosclerotic risk factors still allow room for a large residual risk ...
Christian Weber, Emiel van der Vorst, Yvonne Döring   +2 more
exaly   +3 more sources

Characterization of a chimeric chemokine as a specific ligand for ACKR3 [PDF]

Journal of Leukocyte Biology, 2018
Abstract Chemokines, small chemotactic cytokines, orchestrate cell migration by binding to their cognate chemokine receptors. While chemokine-mediated stimulation of typical G-protein-coupled chemokine receptors leads to cell migration, binding of chemokines to atypical chemokine receptors (ACKRs) does not induce canonical signaling ...
Marcus Thelen, Serena Melgrati, Antal Rot   +2 more
exaly   +6 more sources

Crosstalk between CXCR4/ACKR3 and EGFR Signaling in Breast Cancer Cells

International Journal of Molecular Sciences, 2022
A better understanding of the complex crosstalk among key receptors and signaling pathways involved in cancer progression is needed to improve current therapies. We have investigated in cell models representative of the major subtypes of breast cancer (BC) the interplay between the chemokine CXCL12/CXCR4/ACKR3 and EGF receptor (EGFR) family signaling ...
Petronila Penela Marquez, Maria Neves, Federico Mayor Menendez   +2 more
exaly   +6 more sources

Structural Basis of Nanobody Induced ACKR3 Inhibition

The FASEB Journal, 2022
When bound to their small, secreted chemotactic cytokine ligands (chemokines), the G protein‐coupled receptor (GPCR) subfamily known as chemokine receptors (CKRs) can promote cell proliferation, survival, and migration towards increasing chemokine concentration gradients.
Roman Schlimgen, Francis Peterson, Raimond Heukers, Martine Smit, John McCorvy, Brian Volkman   +5 more
openaire   +1 more source

Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12 [PDF]

International Journal of Molecular Sciences, 2018
Upon binding with the chemokine CXCL12, the chemokine receptor CXCR4 has been shown to promote breast cancer progression. This process, however, can be affected by the expression of the atypical chemokine receptor ACKR3. Given ACKR3’s ability to form heterodimers with CXCR4, we investigated how dual expression of both receptors differed from their lone
Georgina C Wilkins, Irène del Molino del Barrio, Simi Ali   +2 more
exaly   +4 more sources

Single-cell RNA sequencing reveals the MIF/ACKR3 receptor-ligand interaction between neutrophils and nucleus pulposus cells in intervertebral disc degeneration.

Translational Research: The Journal of Laboratory and Clinical Medicine
OBJECTIVES To unravel the heterogeneity and function of microenvironmental neutrophils during intervertebral disc degeneration (IDD). METHODS Single-cell RNA sequencing (scRNA-seq) was utilized to dissect the cellular landscape of neutrophils in ...
Tao-Lan Zhang, Wenkang Chen, Xianjuan Huang, Bo-Wen Zheng, Peng-Fei Wu, Bo-Yv Zheng, Ling-Xiang Jiang, David Escobar, Jing Li, Guo-Hua Lv, Wei Huang, Hong Zhou, Zhun Xu, Ming-Xiang Zou   +13 more
semanticscholar   +1 more source

CXCL12/ACKR3 chemokine axis: a molecular regulator of aortic valve homeostasis and pathology

European Heart Journal
Calcific aortic valve disease (CAVD), the most prevalent valvular heart disease, remains an irreversible and progressive disorder characterized by fibrocalcific remodeling of the aortic valve.
V. Jeyakumar, M. Messner, P. Schoenherr, S. Staggl, C. Puelacher, M. Ungericht, A. Logtenberg, G. Poelzl, A. Bauer, M. M. Zaruba   +9 more
semanticscholar   +1 more source

Binding and ubiquitination-mediated degradation of ACKR3 by the novel Scutellarein derivative TBS6b potently suppresses hepatocellular carcinoma.

Bioorganic chemistry (Print)
Scutellarein, a flavonoid compound from the traditional Chinese herb Scutellaria baicalensis, exhibits inhibitory effects against hepatocellular carcinoma (HCC), but its clinical application is limited by relatively weak potency. To enhance its antitumor
Xing Jiang, Ying Liang, Guotao Tang, Hai-Yan Quan, Lijun Ruan, Mengli Zhang, Zhijun Song, Min Ou, Zhien Tan, Na Lu, Fangfang Wu, Xiaonan Yang   +11 more
semanticscholar   +1 more source