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Diterpenoid Alkaloids from the Lateral Root of Aconitum carmichaelii

Journal of Natural Products, 2012
Twenty-six new diterpenoid alkaloids, 1-26 (1-4: hetisan-type C(20)-diterpenoid alkaloids; 5-26: aconitane C(19)-diterpenoid alkaloids), and two known analogues, hypaconitine 27 and benzoylmesaconine 28, have been isolated from a water extract of the lateral root of Aconitum carmichaelii.
Bingya, Jiang   +10 more
openaire   +2 more sources

Four New Diterpenoid Alkaloids from the Roots of Aconitum carmichaelii

Chemistry & Biodiversity, 2018
Aconitum carmichaelii Debeaux is a widely used traditional Chinese medicine and an important source of clinical drugs, of which the parent and lateral roots are known as ‘Chuanwu’ and ‘Fuzi’, respectively. Four new C19‐diterpenoid alkaloids, carmichasines A – D (1 – 4), were isolated from the roots of Aconitum carmichaelii, together with twelve known ...
Yu, Li   +3 more
openaire   +2 more sources

Cardioprotective effects and concentration-response relationship of aminoalcohol-diterpenoid alkaloids from Aconitum carmichaelii

Fitoterapia, 2021
Fuzi, a well-known traditional Chinese medicine developed from the lateral roots of Aconitum carmichaelii Debx., has been widely used for the treatment of heart failure. In order to search for active compounds from Fuzi, a phytochemical study was performed, which resulted in the isolation of 14 aminoalcohol-diterpenoid alkaloids, including one new ...
Xiao-Ya, Wang   +9 more
openaire   +2 more sources

An Optimized Two-Dimensional Quantitative Nuclear Magnetic Resonance Strategy for the Rapid Quantitation of Diester-Type C19-Diterpenoid Alkaloids from Aconitum carmichaelii.

Analytical Chemistry, 2023
With the development of nuclear magnetic resonance (NMR) spectrometers and probes, two-dimensional quantitative nuclear magnetic resonance (2D qNMR) technology with a high signal resolution and great application potential has become increasingly ...
Qiaoling Lin   +7 more
semanticscholar   +1 more source

Diterpenoids with anti-inflammatory activity from the lateral root of Aconitum carmichaelii debeaux

Phytochemistry, 2022
Five undescribed diterpenoids, including two ent-cleistanthane-type diterpenoids aconicleistanthanes A and B, a hetisine-type diterpenoid aconihetisine A, two aconitines-type diterpenoids aconicarmines A and B, and thirteen known diterpenoids alkaloids, were co-isolated from the lateral root of the Aconitum carmichaelii Debeaux (Ranunculaceae).
Hui, Cui   +6 more
openaire   +2 more sources

Analgesic C20-diterpenoid alkaloids from the lateral roots of Aconitum carmichaelii Debeaux: Natural inhibitors of NLRP3 activation.

Bioorganic chemistry (Print)
Five new C20-diterpenoid alkaloids carmaloidlines A-E (1-5) and a known C20-diterpenoid alkaloid (6) were isolated from the lateral roots of Aconitum carmichaelii Debeaux.
Wei-Feng Yin   +11 more
semanticscholar   +1 more source

Structural feature-based comprehensive characterization of diterpenoid alkaloids of fermented Aconitum carmichaelii Debx in rats by UPLC-Q-Orbitrap MS.

Journal of Chromatography A
The identification of metabolites of Traditional Chinese Medicine (TCM) in vivo is challenging. The complexity of TCM components and matrix interference make it difficult to selectively identify metabolites in vivo.
Xiaoli Li   +4 more
semanticscholar   +1 more source

Integration of offline two-dimensional chromatography and mass defect filtering-based precursor ion list data acquisition for targeted characterization of diterpenoid alkaloids in the lateral roots of Aconitum carmichaelii.

Journal of Chromatography A, 2022
The hyphenated technique of offline two-dimensional (2D) chromatography with high resolution mass spectrometry (MS) was an efficient tool for separation and characterization of components in complex systems such as herbal medicines, especially those co ...
Yang Yu   +10 more
semanticscholar   +1 more source

Potentially Cardiotoxic Diterpenoid Alkaloids from the Roots of Aconitum carmichaelii

Journal of Natural Products, 2019
Aconitum carmichaelii is a traditional Chinese herbal medicine used for the treatment of pain and inflammation in the joints. However, the strong cardiotoxicity hinders its use. Although diester- and monoester-type diterpenoids, e.g., aconitine, mesaconitine, and hypacaonitine, are commonly considered as the toxic components, the toxicity of A ...
Xingxing Zong   +6 more
openaire   +2 more sources

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