Results 161 to 170 of about 2,340 (207)

Synthesis of the acridone alkaloids, glyfoline and congeners. Structure-activity relationship studies of cytotoxic acridones

Journal of Medicinal Chemistry, 1992
Glyfoline (4, 1,6-dihydroxy-10-methyl-2,3,4,5-tetramethoxyacridin-9-one) and its congeners were synthesized for evaluation of their cytotoxicity. A detailed structure-activity relationships (SAR) of these acridone derivatives were also studied. To study the SAR of glyfoline analogues, substituent(s) at C-1 and C-6 and at the heterocyclic nitrogen of ...
T L, Su, B, Köhler, T C, Chou, M W, Chun, K A, Watanabe   +4 more
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Acridone Heterocycles as Fluorescent Sensors for Anions

HETEROCYCLES, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
M. Teresa Blazquez, Francisco M. Muniz, Silvia Saez, Luis M. Simon, Angel Alonso, Cesar Raposo, Anna Lithgow, Victoria Alcazar, Joaquin R. Moran   +8 more
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Reactions in the Acridone‐Fields.

Helvetica Chimica Acta, 1976
Abstract1‐Chlor‐ und 1,7‐Dichlor‐4‐nitro‐acridon wurden mit einigen Phenolen und Bisphenolen zu Farbstoffen umgesetzt, die Polyvinylchlorid grünlichgelb färben. Im Xenotest 800 Std. belichtet, zeigten die einfachen Acridone IX bis XIII eine ungewöhnlich hohe Lichtechtheit; sie sind aber migrationsunecht.
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Equilibrium NH acidities of acridan, phenanthridone, 9-acridone, and substituted 9-acridones

Chemistry of Heterocyclic Compounds, 1982
The equilibrium NH acidities of acridan, phenanthridone, 9-acridone, and 2-substituted 9-acridones (substituents: Me2N, MeO, F, Br, I, and NO2) were measured by transmetallation in dimethyl sulfoxide (DMSO). The role of conjugation and the aromatic character of the heterocyclic ring in stabilization of the anions is discussed.
N. N. Voinovskaya, M. I. Terekhova, T. V. Sakhno, G. A. Val'kova, L. F. Rybakova, �. S. Petrov, A. I. Shatenshtein   +6 more
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Design and Synthesis of Modified Quinolones as Antitumoral Acridones

Journal of Medicinal Chemistry, 1999
The bacterial topoisomerase II (DNA gyrase) and the mammalian topoisomerase II represent the cellular targets for quinolone antibacterials and a wide variety of anticancer drugs, respectively. In view of the mechanistic similarities and sequence homologies exhibited by the two enzymes, tentative efforts to selectively shift from an antibacterial to an ...
TABARRINI, Oriana, CECCHETTI, Violetta, FRAVOLINI, Arnaldo, NOCENTINI, Giuseppe, Barzi A., SABATINI, STEFANO, Miao H., Sissi C.   +7 more
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Mass Spectra of Acridone Alkaloids

Journal of the Chinese Chemical Society, 1989
AbstractThe mass spectra of a variety of simple acridones, prenylacridones, pyranoacridones, dihydropyranoacridones, and furoacridones are presented and discussed. The results illustrate that the characteristic fragmentation patterns are of considerable utility in the application of mass spectrometry to structure elucidation in the acridone alkaloids.
Shaw‐Tao Lin, Tian‐Shung Wu
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9-Acridone from 2,2′-diaminobenzophenone

J. Chem. Soc. C, 1966
9-Acridone and 3,6-dichloro-9-acridone have been prepared in high yields by treatment of the corresponding 2,2′-diaminobenzophenones with 100% phosphoric acid. Boiling hydrochloric acid does not effect these cyclisations.
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Biomimetic synthesis of acridone alkaloids

Journal of the Chemical Society, Perkin Transactions 1, 1977
Cyclisations of 2′-amino-, 2′-acetylamino-, or 2′-methylamino-2-methoxybenzophenones occur in the presence of sodium hydride in dimethyl sulphoxide to give acridone alkaloids. This cyclisation has relevance to the biosynthesis of these alkaloids. An alternative cyclisation can occur, giving 4-arylquinolines or 4-arylquinolones.
Joyce H. Adams, Padma Gupta, M. Shafiq Khan, John R. Lewis   +3 more
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Acridone Synthase: A Key Enzyme in Acridone Alkaloid Biosynthesis

Planta Medica, 1993
D. Gröger, A. Baumert, W. Maier
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Acridones

2018
Rajesh Kumar, Sarita Sharma, Deonandan Prasad   +2 more
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