Results 41 to 50 of about 2,769 (197)
Colour Changes during the Carbamazepine Oxidation by Photo-Fenton [PDF]
, 2021 The oxidation of aqueous solutions of carbamazepine is conducted using the Fenton reagent, combined with the photolytic action of a 150 W medium pressure UV lamp, operating at T = 40 °C.
Camarero Estela, Luis Miguel +5 more
core +1 more source
Acridone alkaloids. X. 13C-Nuclear magnetic resonance spectra of acridone alkaloids.
Chemical and Pharmaceutical Bulletin, 1983 The 13C-nuclear magnetic resonance spectra of twenty-seven acridone alkaloids including angular pyrano [2, 3-c] acridones and linear pyrano [3, 2-b] acridones have been analyzed and assigned. The information should be useful for the structure elucidation of new acridone alkaloids.
HIROSHI FURUKAWA +2 more
openaire +2 more sources
Design, Synthesis and biological evaluation of novel acridine-polyamine conjugates against prostate cancer [PDF]
, 2009 Prostate cancer is the most common cause of cancer death in men, aged 85 and over. Androgen receptor, a single polypeptide with three functional domains is very important during initiation and progression of the disease.
Karodia, N, Maurice, HB, Phillips, Roger
core
Cytotoxic acridone and indoloquinazoline alkaloids from Zanthoxylum poggei [PDF]
Two new alkaloids, poggeicridone (1) and 2-methoxy-7,8- dehydroruteacarpine (6), together with nine known compounds, were isolated from the dichloromethane (DCM) extract of the bark of Zanthoxylum poggei (Engl.) P. G. Waterman.
Wansi, JD +5 more
core +1 more source
The FEBS Journal, EarlyView.Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova +5 more
wiley +1 more source
ChemEngineeringIn this study, we investigated the impact of incorporating energetic substituents such as –NO2, –NH2, –Cl, –F, N-methyl-N-nitro (CH3–N–NO2), and picryl on the detonation performance and stability of acridone-based compounds.
Jelena Tamuliene, Jonas Sarlauskas
doaj +1 more source
Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4. [PDF]
, 2016 The combretastatins are an important class of tubulin-binding agents. Of this family, a number of compounds are potent tumor Vascular Disrupting Agents (VDAs) and have shown promise in the clinic for cancer therapy.
Brown, A.W. +4 more
core +2 more sources
Unravelling the Functional Diversity of Type III Polyketide Synthases in Fungi
Angewandte Chemie, Volume 137, Issue 44, October 27, 2025.Type III polyketide synthases (T3PKSs) produce diverse compounds of ecological and clinical importance. Here, the activity of 37 fungal T3PKSs was profiled, revealing unexpected products and generating several pharmaceutical precursors. The machine learning model trained on the activity data accurately extrapolates the predictions to other enzymes and ...
Nika Sokolova +3 more
wiley +2 more sources
Plant-derived antimalarial agents: from crude extracts to isolated bioactive compounds [PDF]
, 2011 Despite decades of intense research, malaria remains a deadly disease of the developing worlds. Drugresistance to limited available antimalarials, in part, has contributed to the persistence of this infectious disease.
Abdullah, Wan Omar, Ismail, Patimah
core
New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections [PDF]
, 2016 Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently.
Alibana-Clouser, F +38 more
core +4 more sources