Results 1 to 10 of about 43,416 (273)
Nature Reviews Disease Primers, 2019 Acromegaly is characterized by increased release of growth hormone and, consequently, insulin-like growth factor I (IGF1), most often by a pituitary adenoma. Prolonged exposure to excess hormone leads to progressive somatic disfigurement and a wide range of systemic manifestations that are associated with increased mortality. Although considered a rare
Andrea Giustina +2 more
exaly +9 more sources
Altered Brain Function and Network Topology in Patients With Acromegaly: Resting-State fMRI Study of Networks Related to Cognitive and Emotional Processing. [PDF]
CNS Neurosci TherPatients with acromegaly show disrupted brain function and network connectivity, particularly in the default mode and frontal–parietal networks. This study reveals how excess GH and IGF‐1 alter brain activity, offering new insights into the neurobiological mechanisms underlying cognitive decline in acromegaly.
Wu Z +14 more
europepmc +2 more sources
Cost-effectiveness analysis of somatostatin analogues in the treatment of acromegaly in Brazil [PDF]
, 2008 This study aims to compare economic and patient impacts of the treatment of acromegaly with two different somatostatin analogues (octreotide LAR and lanreotide SR) in Brazil. A cost-effectiveness analysis was carried out under the Brazilian Public Health
Joice Valentim +3 more
openalex +6 more sources
Epidemiology of acromegaly: review of population studies [PDF]
Pituitary, 2016 Niki Karavitaki
exaly +2 more sources
The Journal of Clinical Endocrinology & Metabolism, 1997 This review presents a collection of uncommon aspects of acromegaly based on extensive experience of the authors.
COLAO, ANNAMARIA +3 more
openaire +5 more sources
Endocrinology and Metabolism Clinics of North America, 2001 Acromegaly is a slow developing disease caused by hypersecretion of growth hormone and insulin-like growth factor 1. Increased morbidity and mortality associated with the disease make early diagnosis and treatment crucial. This article reviews the etiology, clinical manifestations, and diagnosis of acromegaly, with an emphasis on newly available ...
Anat, Ben-Shlomo, Shlomo, Melmed
openaire +3 more sources
Orphanet Journal of Rare Diseases, 2008 Acromegaly is an acquired disorder related to excessive production of growth hormone (GH) and characterized by progressive somatic disfigurement (mainly involving the face and extremities) and systemic manifestations. The prevalence is estimated at 1:140,000-250,000.
Chanson Philippe, Salenave Sylvie
openaire +4 more sources
BMJ, 2007 Growth hormone (GH) is necessary for normal linear growth. Excess secretion of GH induces gigantism in prepubertal children and acromegaly in adults. Acromegaly arises from GH-secreting pituitary adenomas. Syndromes of excessive secretion of GH or acromegaly are caused 95 % of the time by a pituitary adenoma of the somatotrophs.
openaire +4 more sources
The role of stereotactic radiosurgery in the multimodal management of growth hormone–secreting pituitary adenomas [PDF]
, 2010 Growth hormone (GH)–secreting pituitary adenomas represent a common source of GH excess in patients with acromegaly. Whereas surgical extirpation of the culprit lesion is considered first-line treatment, as many as 19% of patients develop recurrent ...
Liu, Charles Y. +2 more
core +1 more source
Excessive growth hormone expression in male GH transgenic mice adversely alters bone architecture and mechanical strength [PDF]
, 2015 Patients with acromegaly have a higher prevalence of vertebral fractures despite normal bone mineral density (BMD), suggesting that GH overexpression has adverse effects on skeletal architecture and strength. We used giant bovine GH (bGH) transgenic mice
Chavassieux, P +10 more
core +4 more sources