Results 11 to 20 of about 41,662 (214)

Hypersomatotropism and Hypercortisolism Caused by a Plurihormonal Pituitary Adenoma in a Dog. [PDF]

J Vet Intern Med
ABSTRACT A 12‐year‐old, male Labrador Retriever was presented because of polyuria, polydipsia, polyphagia, joint pain, and physical features consistent with acromegaly. Circulating insulin‐like growth factor‐1 (IGF‐1) concentration was increased (> 1000 ng/mL; reference interval [RI], 42–449), suggestive of hypersomatotropism.
Soler Arias EA, Rodas Elvir R, Daly AF, Kooistra HS.   +3 more
europepmc   +2 more sources

Presence of cerebral microbleeds is associated with cognitive decline in acromegaly

Frontiers in Oncology, 2022
BackgroundCognitive decline in acromegaly has gained increasing attention. Cerebral microbleeds (CMBs) as radiographic markers for microvascular injury have been linked to various types of cognitive decline. However, the association between CMB formation
Zhengxing Xie, Zhengxing Xie, Zhengxing Xie, Yan Zhuang, Yan Zhuang, Zongqiang Zhang, Jieping Liu, Jieping Liu   +7 more
doaj   +1 more source

Is H19 RNA a Useful Marker of Acromegaly and Its Complications? A Preliminary Study

Biomedicines, 2023
Acromegaly is a rare endocrine disorder caused by somatotroph pituitary adenoma. Besides its typical symptoms, it contributes to the development of cardiovascular, metabolic, and bone comorbidities. H19 RNA is a long non-coding RNA and it is suspected to
Małgorzata Rolla, Aleksandra Jawiarczyk-Przybyłowska, Katarzyna Kolačkov, Agnieszka Zembska, Marek Bolanowski   +4 more
doaj   +1 more source

Acromegaly without acral anomalies [PDF]

Romanian Journal of Medical Practice, 2021
Early recognition of a pituitary secretor tumor offers a better prognostic; thus acromegaly might be recognized before the actual clinical picture of acromegaly is detectable.
Mara Carsote, Florica Sandru, Diana Elena Rentea, Claudia Mehedintu, Stefania Zugravu, Corina Chirita, Mihai Cristian Dumitrascu   +6 more
doaj   +1 more source

Feline hypersomatotropism and acromegaly tumorigenesis: a potential role for the AIP gene [PDF]

, 2017
Acromegaly in humans is usually sporadic, however up to 20% of familial isolated pituitary adenomas are caused by germline sequence variants of the aryl-hydrocarbon-receptor interacting protein (AIP) gene.
Catchpole, B, Church, D B, Forcada, Y, Fowkes, R C, Niessen, S J M, Scudder, C J   +5 more
core   +1 more source

Clinical effectiveness and cost-effectiveness of pegvisomant for the treatment of acromegaly: a systematic review and economic evaluation [PDF]

, 2009
Background: Acromegaly, an orphan disease usually caused by a benign pituitary tumour, is characterised by hyper-secretion of growth hormone (GH) and insulin-like growth factor I (IGF-1).
A Colao, A Colao, AJ van der Lely, AL Barkan, AN Paisley, AN Paisley, AS Bates, C Parkinson, C Parkinson, C Parkinson, C Parkinson, C Parkinson, Cambridgeshire joint prescribing group decision document, D Moore, David J Moore, G Didoni, G Sesmilo, H Biering, I Schreiber, IM Holdaway, J Ayuk, J Feenstra, JO Jorgensen, Martin J Connock, NHS Centre for Reviews and Dissemination University of York, NR Biermasz, P Chanson, Pfizer Limited, PJ Trainer, R Kauppinen-Makelin, R Kauppinen-Makelin, R Pivonello, R Trepp, S Jehle, S Melmed, SC Hua, SM Orme, SM Webb, Sue Bayliss, SV Rowles, VS Bonert, Welsh Medicines Partnership, WP Fairfield, Yaser Adi   +43 more
core   +4 more sources

CONDITION OF THE MUSCULOSKELETAL SYSTEM IN PATIENTSWITH ACROMEGALY.

Остеопороз и остеопатии, 2010
Despite the relatively low incidence of acromegaly (60-70 cases per I million inhabitants), this disease has a special place among the heterogeneous group of diseases that lead to the defeat of the locomotor apparatus.
A S Fedotova, N N Molitvoslovova, L I Alekseeva, L Ya Rozhinskaya, A. S. Fedotova, N. N. Molitvoslovova, L. I. Alexeeva, L. Y. Rozhinskaya   +7 more
doaj   +1 more source

The role of stereotactic radiosurgery in the multimodal management of growth hormone–secreting pituitary adenomas [PDF]

, 2010
Growth hormone (GH)–secreting pituitary adenomas represent a common source of GH excess in patients with acromegaly. Whereas surgical extirpation of the culprit lesion is considered first-line treatment, as many as 19% of patients develop recurrent ...
Liu, Charles Y., Stapleton, Christopher J., Weiss, Martin H.   +2 more
core   +1 more source

Patient reported outcome data from acromegaly patients treated with injectable somatostatin receptor ligands (SRLs) in routine clinical practice

BMC Endocrine Disorders, 2020
Background Acromegaly patients managed on Somatostatin receptor ligands (SRLs), the most common first-line pharmacotherapy for acromegaly, may still experience acromegaly symptoms such as headache, sweating, fatigue, soft tissue swelling, and joint pain,
Eliza B. Geer, Jill Sisco, Daphne T. Adelman, William H. Ludlam, Asi Haviv, Shuqian Liu, Susan D. Mathias, Dana Gelbaum, Lizheng Shi   +8 more
doaj   +1 more source

Hyperglycemia induced by pasireotide in patients with Cushing’s disease or acromegaly [PDF]

, 2016
PURPOSE: Cushing’s disease (CD) and acromegaly are characterized by excessive hormone secretion resulting in comorbidities such as impaired glucose metabolism, diabetes and hypertension.
Silverstein, Julie M
core   +2 more sources