Results 31 to 40 of about 38,436 (213)
High Sensitivity Mass Spectrometric Quantification of Serum Growth Hormone by Amphiphilic Peptide Conjugation [PDF]
J Mass Spectrom 47(2012)1554, 2012 Amphiphilic peptide conjugation affords a significant increase in sensitivity with protein quantification by electrospray-ionization mass spectrometry. This has been demonstrated here for human growth hormone in serum using N-(3-iodopropyl)-N,N,N-dimethyloctylammonium iodide (IPDOA-iodide) as derivatizing reagent.
arxiv +1 more source
Acromegaly: an endocrine society clinical practice guideline.
Journal of Clinical Endocrinology and Metabolism, 2014 OBJECTIVE The aim was to formulate clinical practice guidelines for acromegaly. PARTICIPANTS The Task Force included a chair selected by the Endocrine Society Clinical Guidelines Subcommittee (CGS), five experts in the field, and a methodologist.
L. Katznelson +6 more
semanticscholar +1 more source
Prolonged Diagnostic Delay in Acromegaly is Associated with Increased Morbidity and Mortality.
European Journal of Endocrinology, 2020 CONTEXT Clinical features of acromegaly develop insidiously. Its diagnosis may therefore be delayed. OBJECTIVE Our aim was to study diagnostic delay and its impact on morbidity and mortality in a nationwide cohort of patients with acromegaly.
D. Esposito +3 more
semanticscholar +1 more source
Acromegaly, inflammation and cardiovascular disease: a review
Reviews in Endocrine & Metabolic Disorders, 2020 Acromegaly is characterized by Growth Hormone (GH) and Insulin-like Growth Factor 1 (IGF-1) excess. Uncontrolled acromegaly is associated with a strongly increased risk of cardiovascular disease (CVD), and numerous cardiovascular risk factors remain ...
Thalijn L C Wolters +4 more
semanticscholar +1 more source
Journal of Clinical Endocrinology and Metabolism, 2020 PURPOSE Osteopathy is an emerging complication of acromegaly. In somatostatin receptor ligands (SRL)-resistant patients, Pegvisomant (PegV) and Pasireotide LAR (Pasi) are used for acromegaly treatment, but their effect on skeletal health is still not ...
S. Chiloiro +10 more
semanticscholar +1 more source
Risk for acromegaly-related comorbidities by sex in Korean acromegaly.
Journal of Clinical Endocrinology and Metabolism, 2020 CONTEXT Reports on the incidence, characteristics, and comorbidity in Asian patients with acromegaly are scarce. OBJECTIVE To evaluate the incidence of acromegaly and risk of comorbidities in East Asia, especially South Korea.
K. Park, Eun Jig Lee, G. Seo, C. Ku
semanticscholar +1 more source
Frontiers in Endocrinology, 2019 Introduction: The vitamin D receptor (VDR) gene is one of the most widely studied tumorigenesis-related genes. The primary objective of this study was assessment of possible roles of VDR gene polymorphisms in acromegaly, with regard to the activity of ...
Aleksandra Jawiarczyk-Przybyłowska +5 more
doaj +1 more source
Reproductive Biology and Endocrinology, 2023 Background Acromegaly is a disease of growth hormone excess that results in enlargement of extremities, abnormal glucose and lipid metabolism, and gonadal disruption. Manifestations of the disease are insidious and typically lead to a diagnostic delay of
Anamil M. Khiyami +6 more
doaj +1 more source
Systemic Complications of Acromegaly and the Impact of the Current Treatment Landscape: An Update.
Endocrine reviews, 2018 Acromegaly is a chronic systemic disease with many complications and is associated with increased mortality when not adequately treated. Substantial advances in acromegaly treatment, as well as in the treatment of many of its complications, mainly ...
M. Gadelha +3 more
semanticscholar +1 more source
Prevalence of acromegaly in patients with symptoms of sleep apnea.
PLoS ONE, 2017 Acromegaly is a rare disease with nonspecific symptoms with acral enlargement being almost universally present at diagnosis. The estimated prevalence is 40-125 cases/million but targeted universal screening studies have found a higher prevalence (about ...
Gemma Sesmilo +14 more
doaj +1 more source