Mechanisms That Protect Mammalian Sperm from the Spontaneous Acrosome Reaction. [PDF]
Int J Mol Sci, 2023 To acquire the capacity to fertilize the oocyte, mammalian spermatozoa must undergo a series of biochemical reactions in the female reproductive tract, which are collectively called capacitation. The capacitated spermatozoa subsequently interact with the
Breitbart H, Grinshtein E.
europepmc +3 more sources
Regulating the acrosome reaction [PDF]
The International Journal of Developmental Biology, 2008 The acrosome reaction is a secretory event that must be completed by the sperm of many animal species prior to fusion with eggs. In mammals, exocytosis in triggered by ZP3, a glycoprotein component of the egg pellucida, following gamete contact. ZP3 promotes a sustained influx of Ca2+ into sperm that is necessary for the acrosome reaction.
Florman, Harvey M. +2 more
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CD147 deficiency is associated with impairedsperm motility/acrosome reaction and offersa therapeutic target for asthenozoospermia [PDF]
Molecular Therapy: Nucleic Acids, 2021 Patients with asthenozoospermia often present multiple defects in sperm functions apart from a decrease in sperm motility. However, the etiological factors underlying these multifaceted defects remain mostly unexplored, which may lead to unnecessary ...
Hao Chen +16 more
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Effect of phosphodiesterase type 5 inhibitors on sperm motility and acrosome reaction: An in vitro study [PDF]
Investigative and Clinical Urology, 2021 Purpose: Phosphodiesterase type 5 (PDE5) inhibitors are effective treatments for erectile dysfunction, and several recent studies have reported positive effects of PDE5 inhibitors on semen parameters as well. However, the data are still controversial. We
Seung-Hun Song +8 more
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Specific lectin binding sites during in vitro capacitation and acrosome reaction in boar spermatozoa [PDF]
Italian Journal of Animal Science, 2021 Sperm glycocalyx and plasma membrane undergo outstanding modifications during fertilization. However, it is unclear how in vitro capacitation time and acrosome reaction affect the specific location of boar sperm glycoconjugates.
Laura Robles-Gómez +6 more
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Glycogen Synthase Kinase-3 Regulates Sperm Motility and Acrosome Reaction via Affecting Energy Metabolism in Goats [PDF]
Frontiers in Physiology, 2019 Hyperactivation and acrosome reaction of sperm are pre-requisite steps for fertilization. However, the hyperactivation and acrosome reaction are critically controlled through the phosphorylation of specific proteins.
Zhendong Zhu +7 more
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MicroRNAs and Their Associated Genes Regulating the Acrosome Reaction in Sperm of High- versus Low-Fertility Holstein Bulls [PDF]
AnimalsBioinformatics envisage experimental data as illustrated biological networks, exploring roles of individual proteins and their interactions with other proteins in regulation of biological functions.
Vanmathy Kasimanickam +1 more
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Artemisia vulgaris extract causes precocious acrosome reaction and viability loss but low rate of membrane damage in mouse spermatozoa [PDF]
Journal of Animal Science and Technology, 2021 Several herbs including Artemisia are known to possess conceptive property. In the present study, mouse spermatozoa were incubated with ethanol extract of Artemisia vulgaris leaves. The effect of
Sabina Bhandari +4 more
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Acrosome reaction in morphologically different types of human spermatozoa
Zdravniški Vestnik, 2011 Background: The aim of our study was to ascertain if the acrosome functionality differs between various morphological types of spermatozoa in human. Methods: Fourteen ejaculates were resuspended in the culture medium with the aim to wash the spermatozoa ...
Mojca Čižek Sajko +2 more
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Delineation of downstream signalling components during acrosome reaction mediated by heat solubilized human zona pellucida [PDF]
Reproductive Biology and Endocrinology, 2010 Background Human egg is enveloped by a glycoproteinaceous matrix, zona pellucida (ZP), responsible for binding of the human spermatozoa to the egg and induction of acrosomal exocytosis in the spermatozoon bound to ZP.
Talwar Pankaj +3 more
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