Results 31 to 40 of about 13,944 (183)

A mechanism for differential release of acrosomal enzymes during the acrosome reaction [PDF]

Biochemical Journal, 1991
To study the organization of fertilization enzymes in the sperm acrosome, we isolated and characterized two physicochemically distinct acrosomal fractions of guinea-pig spermatozoa. A soluble fraction contained the 25,000-Mr acrosomal autoantigen, AA1, and most of the acrosomal hyaluronidase and dipeptidyl peptidase II activity. A particulate fraction,
D M, Hardy, M N, Oda, D S, Friend, T T, Huang   +3 more
openaire   +2 more sources

Delineation of downstream signalling components during acrosome reaction mediated by heat solubilized human zona pellucida

Reproductive Biology and Endocrinology, 2010
Background Human egg is enveloped by a glycoproteinaceous matrix, zona pellucida (ZP), responsible for binding of the human spermatozoa to the egg and induction of acrosomal exocytosis in the spermatozoon bound to ZP.
Talwar Pankaj, Bansal Pankaj, Bhandari Beena, Gupta Satish K   +3 more
doaj   +1 more source

Oocyte–cumulus cell interaction: a key factor in early embryo development

Biological Reviews, EarlyView.
ABSTRACT The evaluation of oocyte competence is a fundamental step in achieving successful outcomes following assisted reproduction techniques (ART). At present, however, conventional oocyte maturation assessment is carried out by morphological observation, which is a subjective method that does not consider molecular features.
Marc Torres‐Garrido, Marc Yeste, Yentel Mateo‐Otero   +2 more
wiley   +1 more source

Heat stress in spermatogenesis: a redox‐dependent decision network linking ROS, autophagy, and regulated cell death

Biological Reviews, EarlyView.
ABSTRACT Heat stress (HS) is an increasing threat to male reproductive health, disrupting spermatogenesis through complex and interdependent cellular responses within the seminiferous epithelium. Although excessive reactive oxygen species (ROS) production is a hallmark of HS, ROS also act as central regulators of cell fate decisions beyond their role ...
Ribrio Ivan Tavares Pereira Batista
wiley   +1 more source

Characterization of expression patterns and dynamic relocation of Notch proteins during acrosome reaction of bull spermatozoa

Scientific Reports
Notch is a conserved cell-signaling pathway involved in spermatogenesis regulation. This study firstly evaluated the presence, localization patterns, acquisition origin and relation to acrosome reaction of Notch proteins in bull sperm.
Patrícia Diniz, Inês Leites, Mariana R. Batista, Ana Catarina Torres, Luísa Mateus, Luís Lopes-da-Costa, Elisabete Silva   +6 more
doaj   +1 more source

Nitric oxide involvement in the acrosome reaction triggered by leptin in pig sperm

Reproductive Biology and Endocrinology, 2011
Background Nitric oxide (NO) is a signaling molecule produced by intracellular nitric oxide synthase (NOS) enzymes. This free radical appears to affect sperm capacitation, a maturation step preceding acrosome reaction. Recent studies have reported leptin
Guido Carmela, Giordano Francesca, Aquila Saveria, Rago Vittoria, Carpino Amalia   +4 more
doaj   +1 more source

Protective Effects of Fenugreek and Stevia Extracts on Dexamethasone‐Induced Testicular Damage in a Rat Model

Food Safety and Health, EarlyView.
Fenugreek and stevia extracts protect against dexamethasone‐induced testicular damage in male rats by enhancing antioxidant defenses, improving sperm quality, and restoring hormonal balance, highlighting their potential as natural therapeutics for preventing corticosteroid‐induced reproductive toxicity.
Mosab Gad, Medhat Ibrahim A. Omar, Mohammed I. Elkhateeb, Ahmed A. Zaky   +3 more
wiley   +1 more source

The effect of non-traditional cooling on dog sperm cryosurvival and ability to perform the acrosome reaction

Austral Journal of Veterinary Sciences, 2019
The objective of this study was to assess cryosurvival, plasma membrane fluidity, and capability of cryopreserved dog (Canis lupus familiaris) spermatozoa, cooled to –5 °C before freezing, to perform the acrosome reaction under the effect of progesterone
Luis D. Ortega-Morales, Alicia Alcantar-Rodriguez, Maria C. Espejel, Alfredo Medrano   +3 more
doaj   +1 more source

Sperm capacitation and the acrosome reaction [PDF]

Human Reproduction, 1998
To achieve successful fertilization under normal circumstances in vivo, mammalian spermatozoa must first undergo capacitation and then the acrosome reaction, an exocytotic event that allows cells to penetrate the zona pellucida and fuse with the oocyte plasma membrane.
openaire   +2 more sources

Potential Neuroendocrine Disruption by Benzodiazepines and Its Impact on Male Fertility

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neuroactive substances have emerged as potent endocrine disruptors affecting male reproductive health through central and peripheral mechanisms. Among these, benzodiazepines, which are widely used for the management of anxiety, insomnia, epilepsy, and neuromuscular disorders, are known as GABA A (gamma‐aminobutyric acid type A) receptor ...
Ana Clara Melo Andrade de Rodrigues, Julia Gonçalves Rodrigues, Marcos de Lucca Moreira Gomes, Fernanda Carolina Ribeiro Dias   +3 more
wiley   +1 more source