Results 11 to 20 of about 1,019,366 (314)

CAPG Is Required for Ebola Virus Infection by Controlling Virus Egress from Infected Cells

Viruses, 2022
The replication of Ebola virus (EBOV) is dependent upon actin functionality, especially at cell entry through macropinocytosis and at release of virus from cells.
Hiroyuki Mori, James P. Connell, Callie J. Donahue, RuthMabel Boytz, Yen Thi Kim Nguyen, Daisy W. Leung, Douglas J. LaCount, Robert A. Davey   +7 more
doaj   +1 more source

The Cytoskeleton Effectors Rho-Kinase (ROCK) and Mammalian Diaphanous-Related (mDia) Formin Have Dynamic Roles in Tumor Microtube Formation in Invasive Glioblastoma Cells

Cells, 2022
Glioblastoma (GBM) is a progressive and lethal brain cancer. Malignant control of actin and microtubule cytoskeletal mechanics facilitates two major GBM therapeutic resistance strategies—diffuse invasion and tumor microtube network formation.
Kathryn N. Becker, Krista M. Pettee, Amanda Sugrue, Kevin A. Reinard, Jason L. Schroeder, Kathryn M. Eisenmann   +5 more
doaj   +1 more source

Anti-phospholipase A2 receptor antibodies directly induced podocyte damage in vitro

Renal Failure, 2022
Background The pathogenesis of primary membranous nephropathy (MN) involves the antibodies against antigens on the cell surface of podocytes, with the majority of M-type phospholipase A2 receptor (PLA2R), and a profound podocyte dysfunction.
Yanfen Li, Juntao Yu, Miao Wang, Zhao Cui, Ming-hui Zhao   +4 more
doaj   +1 more source

Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes

eLife, 2017
Leukocytes and other amoeboid cells change shape as they move, forming highly dynamic, actin-filled pseudopods. Although we understand much about the architecture and dynamics of thin lamellipodia made by slow-moving cells on flat surfaces, conventional ...
Lillian K Fritz-Laylin, Megan Riel-Mehan, Bi-Chang Chen, Samuel J Lord, Thomas D Goddard, Thomas E Ferrin, Susan M Nicholson-Dykstra, Henry Higgs, Graham T Johnson, Eric Betzig, R Dyche Mullins   +10 more
doaj   +1 more source

Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts

Journal of Cell Biology, 1993
Granulation tissue fibroblasts (myofibroblasts) develop several ultrastructural and biochemical features of smooth muscle (SM) cells, including the presence of microfilament bundles and the expression of alpha-SM actin, the actin isoform typical of ...
Alexis Desmoulière, A. Geinoz, F. Gabbiani, Giulio Gabbiani   +3 more
semanticscholar   +1 more source

Actomyosin Contractility in the Generation and Plasticity of Axons and Dendritic Spines

Cells, 2020
Actin and non-muscle myosins have long been known to play important roles in growth cone steering and neurite outgrowth. More recently, novel functions for non-muscle myosin have been described in axons and dendritic spines.
Marina Mikhaylova, Jakob Rentsch, Helge Ewers   +2 more
doaj   +1 more source

SARM1 Suppresses Axon Branching Through Attenuation of Axonal Cytoskeletal Dynamics

Frontiers in Molecular Neuroscience, 2022
Axon branching is a fundamental aspect of neuronal morphogenesis, neuronal circuit formation, and response of the nervous system to injury. Sterile alpha and TIR motif containing 1 (SARM1) was initially identified as promoting Wallerian degeneration of ...
Andrea Ketschek, Sabrina M. Holland, Gianluca Gallo, Gianluca Gallo   +3 more
doaj   +1 more source

Phosphorylation acts positively and negatively to regulate MRTF-A subcellular localisation and activity

eLife, 2016
The myocardin-related transcription factors (MRTF-A and MRTF-B) regulate cytoskeletal genes through their partner transcription factor SRF. The MRTFs bind G-actin, and signal-regulated changes in cellular G-actin concentration control their nuclear ...
Richard Panayiotou, Francesc Miralles, Rafal Pawlowski, Jessica Diring, Helen R Flynn, Mark Skehel, Richard Treisman   +6 more
doaj   +1 more source

Nucleotide-dependent activities of FtsA regulate the early establishment of a functional divisome during the Escherichia coli cell cycle

Frontiers in Microbiology, 2023
During cell division in Escherichia coli, the highly conserved tubulin homolog FtsZ polymerizes and assembles into a ring-like structure, called the Z-ring, at the site of septation.
Josiah J. Morrison, Colby N. Ferreira, Evelyn M. Siler, Katie Nelson, Catherine E. Trebino, Benjamin Piraino, Jodi L. Camberg   +6 more
doaj   +1 more source

Flexural rigidity of microtubules and actin filaments measured from thermal fluctuations in shape

Journal of Cell Biology, 1993
Microtubules are long, proteinaceous filaments that perform structural functions in eukaryotic cells by defining cellular shape and serving as tracks for intracellular motor proteins.
F. Gittes, B. Mickey, J. Nettleton, J. Howard   +3 more
semanticscholar   +1 more source