Results 201 to 210 of about 836,845 (268)

Stromal‐Derived IL‐8 Promotes M2 Macrophage Polarization via the RhoA/MRTF‐A/SRF Transcriptional Axis to Impair CD8+ T Cell Cytotoxicity in Lung Cancer

Advanced Science, EarlyView.
In the recondite pulmonary neoplastic milieu, DESMIN+ cancer‐associated fibroblasts function as the paramount stromal source of IL‐8, precipitating a deleterious immunological metamorphosis by engaging CXCR2 receptors on the myeloid lineage. This paracrine stimulus triggers a mechanotransduction cascade characterized by RhoA‐dependent actin ...
Xuyu Gu, Qiyu Fang, Jia Yu, Ting Yu, Huashan Shi, Kaiqi Jin, Lei Jiang, Wentian Zhang   +7 more
wiley   +1 more source

Endothelial β-PIX (ARHGEF7) supports actomyosin mediated expulsion of VWF through dynamic reorganization of the cytoskeleton. [PDF]

Mol Biol Cell
El-Mansi S, Deegan KM, Nightingale TD.
europepmc   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Integrating Modeling and Microscopy Reveals the Role of Nascent Focal Adhesions in Cell Migration

SALVADORI A, Maini V, Serpelloni M, Raimondi MT, Jacchetti E.   +4 more
europepmc   +1 more source

CARMIL membrane-binding domain regulates capping protein and actin assembly. [PDF]

J Biol Chem
Mooren OL, McConnell P, DeBrecht JD, Cooper JA.   +3 more
europepmc   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Building the bridges: molecular mechanisms of tunneling nanotube formation. [PDF]

Cell Mol Life Sci
Brou C, Zurzolo C.
europepmc   +1 more source

Optical Control of Actin Network Assembly on the Supported Lipid Bilayer. [PDF]

Bio Protoc
Yamamoto K, Miyazaki M.
europepmc   +1 more source

Myosin forces remodel F-actin for mechanosensitive protein recognition. [PDF]

Nature
Carl AG, Reynolds MJ, Sun X, Gurel PS, Phua DYZ, Hamilton K, Mei L, Watters JW, Takagi Y, Noble AJ, Sellers JR, Alushin GM.   +11 more
europepmc   +1 more source

Impaired cortical actin dynamics via lanosterol-dependent HMG-CoA reductase downregulation mediates IFN-α-induced mast cell stabilization. [PDF]

J Biol Chem
Naskar R, Ye L, Karan S, Hong KS, Yeom Y, Hwang I.   +5 more
europepmc   +1 more source