Results 21 to 30 of about 1,019,366 (314)

miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis

eLife, 2014
Genome-encoded microRNAs (miRNAs) provide a posttranscriptional regulatory layer that controls the differentiation and function of various cellular systems, including hematopoietic cells. miR-142 is one of the most prevalently expressed miRNAs within the
Elik Chapnik, Natalia Rivkin, Alexander Mildner, Gilad Beck, Ronit Pasvolsky, Eyal Metzl-Raz, Yehudit Birger, Gail Amir, Itay Tirosh, Ziv Porat, Liron L Israel, Emmanuel Lellouche, Shulamit Michaeli, Jean-Paul M Lellouche, Shai Izraeli, Steffen Jung, Eran Hornstein   +16 more
doaj   +1 more source

Siglec-8 Signals Through a Non-Canonical Pathway to Cause Human Eosinophil Death In Vitro

Frontiers in Immunology, 2021
Sialic acid-binding immunoglobulin-like lectin (Siglec)-8 is a glycan-binding receptor bearing immunoreceptor tyrosine-based inhibitory and switch motifs (ITIM and ITSM, respectively) that is selectively expressed on eosinophils, mast cells, and, to a ...
Daniela J. Carroll, Yun Cao, Bruce S. Bochner, Jeremy A. O’Sullivan   +3 more
doaj   +1 more source

Actin cortex architecture regulates cell surface tension

Nature Cell Biology, 2017
Animal cell shape is largely determined by the cortex, a thin actin network underlying the plasma membrane in which myosin-driven stresses generate contractile tension. Tension gradients result in local contractions and drive cell deformations.
P. Chugh, Andrew G. Clark, Matthew B. Smith, D. Cassani, K. Dierkes, Anan Ragab, Philippe P Roux, G. Charras, G. Salbreux, E. Paluch   +9 more
semanticscholar   +1 more source

High Temporal Resolution 3D Live-Cell Imaging of Budding Yeast Meiosis Defines Discontinuous Actin/Telomere-Mediated Chromosome Motion, Correlated Nuclear Envelope Deformation and Actin Filament Dynamics

Frontiers in Cell and Developmental Biology, 2021
Chromosome movement is prominent at mid-meiotic prophase and is proposed to enhance the efficiency and/or stringency of homolog pairing and/or to help prevent or resolve topological entanglements.
Tadasu Nozaki, Frederick Chang, Beth Weiner, Nancy Kleckner   +3 more
doaj   +1 more source

Effects of cytochalasin and phalloidin on actin

Journal of Cell Biology, 1987
C YTOCHALASINS and phalloidins are two groups of small, naturally occurring organic molecules that bind to actin and alter its polymerization. They have been widely used to study the role of actin in biological processes and as models for actin-binding ...
J. Cooper
semanticscholar   +1 more source

Wound Repair of the Cell Membrane: Lessons from Dictyostelium Cells

Cells
The cell membrane is frequently subjected to damage, either through physical or chemical means. The swift restoration of the cell membrane’s integrity is crucial to prevent the leakage of intracellular materials and the uncontrolled influx of ...
Shigehiko Yumura
doaj   +1 more source

Tugging at the Heart Strings: The Septin Cytoskeleton in Heart Development and Disease

Journal of Cardiovascular Development and Disease, 2020
Septin genes were originally identified in budding yeast in 1971. Since their original discovery, at least 13 mammalian genes have now been found, which give rise to a vast array of alternatively spliced proteins that display unique spatial-temporal ...
Kelsey Moore, Reece Moore, Christina Wang, Russell A. Norris   +3 more
doaj   +1 more source

The actin cortex at a glance

Journal of Cell Science, 2018
Precisely controlled cell deformations are key to cell migration, division and tissue morphogenesis, and have been implicated in cell differentiation during development, as well as cancer progression.
P. Chugh, E. Paluch
semanticscholar   +1 more source

A role for tunneling nanotubes in virus spread

Frontiers in Microbiology
Tunneling nanotubes (TNTs) are actin-rich intercellular conduits that mediate distant cell-to-cell communication and enable the transfer of various cargos, including proteins, organelles, and virions.
Weimiao Lv, Weimiao Lv, Weimiao Lv, Zichen Li, Zichen Li, Shule Wang, Jingyi He, Leiliang Zhang, Leiliang Zhang, Leiliang Zhang   +9 more
doaj   +1 more source

The fat body cortical actin network regulates Drosophila inter-organ nutrient trafficking, signaling, and adipose cell size

eLife, 2023
Defective nutrient storage and adipocyte enlargement (hypertrophy) are emerging features of metabolic syndrome and type 2 diabetes. Within adipose tissues, how the cytoskeletal network contributes to adipose cell size, nutrient uptake, fat storage, and ...
Rupali Ugrankar-Banerjee, Son Tran, Jade Bowerman, Anastasiia Kovalenko, Blessy Paul, W Mike Henne   +5 more
doaj   +1 more source