Results 21 to 30 of about 976,237 (341)
eLife, 2021 Metazoan proteomes contain many paralogous proteins that have evolved distinct functions. The Ena/VASP family of actin regulators consists of three members that share an EVH1 interaction domain with a 100 % conserved binding site.
Theresa Hwang +6 more
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Actin, actin-binding proteins, and actin-related proteins in the nucleus [PDF]
Histochemistry and Cell Biology, 2016 Extensive research in the past decade has significantly broadened our view about the role actin plays in the life of the cell and added novel aspects to actin research. One of these new aspects is the discovery of the existence of nuclear actin which became evident only recently.
Kristó, Ildikó +4 more
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Single-molecule imaging reveals the concerted release of myosin from regulated thin filaments
eLife, 2021 Regulated thin filaments (RTFs) tightly control striated muscle contraction through calcium binding to troponin, which enables tropomyosin to expose myosin-binding sites on actin. Myosin binding holds tropomyosin in an open position, exposing more myosin-
Quentin M Smith +4 more
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Trends in Cell Biology, 1996 The most biologically significant property of actin is its ability to self-associate and form two-stranded polymeric microfilaments. In living cells, these micro filaments form the actin cytoskeleton, essential for maintenance of the shape, passive mechanical properties and active motility of eukaryotic cells. Recently discovered actin-related proteins
Thomas D. Pollard +2 more
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Mechanics and regulation of cytokinetic abscission
Frontiers in Cell and Developmental Biology, 2022 Cytokinetic abscission leads to the physical cut of the intercellular bridge (ICB) connecting the daughter cells and concludes cell division. In different animal cells, it is well established that the ESCRT-III machinery is responsible for the ...
Virginia Andrade +2 more
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Visualizing molecules of functional human profilin
eLife, 2022 Profilin-1 (PFN1) is a cytoskeletal protein that regulates the dynamics of actin and microtubule assembly. Thus, PFN1 is essential for the normal division, motility, and morphology of cells.
Morgan L Pimm +5 more
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A Supramolecular Polymerization Approach to the Growth of the Myofibril
Frontiers in Chemistry, 2019 Extended linear structures self-assemble by the multi-stage-open-association mechanism of supramolecular polymerization (MSOA). Application of the model requires the identification of a repeating unit, the main-chain supramolecular bond, and the binding ...
Alberto Ciferri, Alvin L. Crumbliss
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Nature Reviews Genetics, 2018 Two independent studies now show that polymerization of branched actin at DNA double-strand breaks (DSBs) mediates chromatin dynamics associated with homology-directed repair and is required for a robust and error-free DSB repair process.
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Computational prediction of actin–actin interaction [PDF]
Molecular Biology Reports, 2013 Actin is one of the most abundant proteins in eukaryotic cells, where it plays key roles in cell shape, motility, and regulation. Actin is found in globular (G) and filamentous (F) structure in the cell. The helix of actin occurs as a result of polymerization of monomeric G-actin molecules through sequential rowing, is called F-actin.
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