Results 31 to 40 of about 815,791 (269)

Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture

Cell Reports, 2015
Lateral diffusion in the membrane and endosomal trafficking both contribute to the addition and removal of AMPA receptors (AMPARs) at postsynaptic sites.
Marta Esteves da Silva, Max Adrian, Philipp Schätzle, Joanna Lipka, Takuya Watanabe, Sukhee Cho, Kensuke Futai, Corette J. Wierenga, Lukas C. Kapitein, Casper C. Hoogenraad   +9 more
doaj   +1 more source

Actin stress fibre subtypes in mesenchymal-migrating cells [PDF]

Open Biology, 2013
Mesenchymal cell migration is important for embryogenesis and tissue regeneration. In addition, it has been implicated in pathological conditions such as the dissemination of cancer cells.
Tea Vallenius
doaj   +1 more source

Visualizing molecules of functional human profilin

eLife, 2022
Profilin-1 (PFN1) is a cytoskeletal protein that regulates the dynamics of actin and microtubule assembly. Thus, PFN1 is essential for the normal division, motility, and morphology of cells.
Morgan L Pimm, Xinbei Liu, Farzana Tuli, Jennifer Heritz, Ashley Lojko, Jessica L Henty-Ridilla   +5 more
doaj   +1 more source

Chlamydia Hijacks ARF GTPases To Coordinate Microtubule Posttranslational Modifications and Golgi Complex Positioning

mBio, 2017
The intracellular bacterium Chlamydia trachomatis develops in a parasitic compartment called the inclusion. Posttranslationally modified microtubules encase the inclusion, controlling the positioning of Golgi complex fragments around the inclusion.
Jordan Wesolowski, Mary M. Weber, Agata Nawrotek, Cheryl A. Dooley, Mike Calderon, Claudette M. St. Croix, Ted Hackstadt, Jacqueline Cherfils, Fabienne Paumet   +8 more
doaj   +1 more source

A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers

eLife, 2021
Metazoan proteomes contain many paralogous proteins that have evolved distinct functions. The Ena/VASP family of actin regulators consists of three members that share an EVH1 interaction domain with a 100 % conserved binding site.
Theresa Hwang, Sara S Parker, Samantha M Hill, Meucci W Ilunga, Robert A Grant, Ghassan Mouneimne, Amy E Keating   +6 more
doaj   +1 more source

Phosphoprofile reorganization of the actin binding protein Drebrin during long term depression

Frontiers in Molecular Neuroscience
Drebrin (DBN), an actin-binding protein critical for the structural integrity and function of dendritic spines, is highly phosphorylated at steady state in neurons.
Rafaela Pedro Silva, Rafaela Pedro Silva, Till G. A. Mack, Marieluise Kirchner, Philipp Mertins, Britta J. Eickholt, Patricia Kreis   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

A new family of bacterial actin-like proteins regulates cell morphology in a filamentous cyanobacterium

mSphere
Actin proteins are common to all domains of life and exhibit ATP-dependent polymerization to form filaments. In bacteria, four families of bacterial actin-like proteins (BALPs) have been identified and characterized.
Alicia Nguyen, Garrett M. Jenkins, Peyton D. Brones, Gabriel A. Parrett, Guy M. Hagen, Jeremy M. Bono, Douglas D. Risser   +6 more
doaj   +1 more source

Ofloxacin as a Disruptor of Actin Aggresome “Hirano Bodies”: A Potential Repurposed Drug for the Treatment of Neurodegenerative Diseases

Frontiers in Aging Neuroscience, 2020
There is a growing number of aging populations that are more prone to the prevalence of neuropathological disorders. Two major diseases that show a late onset of the symptoms include Alzheimer’s disorder (AD) and Parkinson’s disorder (PD), which are ...
Samridhi Pathak, Haifa Parkar, Sarita Tripathi, Avinash Kale   +3 more
doaj   +1 more source

Age-dependent increase of cytoskeletal components in sensory axons in human skin

Frontiers in Cell and Developmental Biology, 2022
Aging is a complex process characterized by several molecular and cellular imbalances. The composition and stability of the neuronal cytoskeleton is essential for the maintenance of homeostasis, especially in long neurites.
Klara Metzner, Klara Metzner, Omar Darawsha, Mengzhe Wang, Nayana Gaur, Nayana Gaur, Yiming Cheng, Annekathrin Rödiger, Christiane Frahm, Otto W. Witte, Fabiana Perocchi, Fabiana Perocchi, Fabiana Perocchi, Hubertus Axer, Julian Grosskreutz, Julian Grosskreutz, Monika S. Brill, Monika S. Brill   +17 more
doaj   +1 more source