Results 61 to 70 of about 976,237 (341)
Frontiers in Plant Science, 2022 The linker of nucleoskeleton and cytoskeleton (LINC) complex is a protein complex spanning the inner and outer membranes of the nuclear envelope. Outer nuclear membrane KASH proteins interact in the nuclear envelope lumen with inner nuclear membrane SUN ...
Alecia Biel +6 more
doaj +1 more source
Actin dynamics: Assembly and disassembly of actin networks [PDF]
Current Biology, 2000 Assembly of branched actin filament networks at the leading edge of migrating cells requires stimulation of the Arp2/3 complex by WASp proteins, in concert with the WASp activators Cdc42, PIP(2) and profilin. Network disassembly and debranching appears to be linked to actin-bound ATP hydrolysis as filaments age.
Martin A. Wear +2 more
openaire +3 more sources
Purification tags markedly affect self‐aggregation of CPEB3
FEBS Letters, EarlyView.Although recombinant proteins are used to study protein aggregation in vitro, uncleaved tags can interfere with accurate interpretation. Our findings demonstrate that His₆‐GFP and His₁₂ tags significantly affect liquid droplet and amyloid fibril formation in the intrinsically disordered region (IDR) of mouse cytoplasmic polyadenylation element‐binding ...
Harunobu Saito +6 more
wiley +1 more source
HIV Infection of T Cells: Actin-in and Actin-out [PDF]
Science Signaling, 2009 The coordinated activities of various actin-binding proteins facilitate entry of HIV into T cells.
Liu, Y., Belkina, N. V., Shaw, S.
openaire +3 more sources
FEBS Letters, EarlyView.In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi +5 more
wiley +1 more source
eLife, 2014 Epsin is an evolutionarily conserved endocytic clathrin adaptor whose most critical function(s) in clathrin coat dynamics remain(s) elusive. To elucidate such function(s), we generated embryonic fibroblasts from conditional epsin triple KO mice.
Mirko Messa +10 more
doaj +1 more source
Frontiers in Endocrinology, 2023 β-arrestins, which have multiple cellular functions, were initially described as proteins that desensitize rhodopsin and other G protein-coupled receptors.
Tibor Szénási +4 more
doaj +1 more source
Biophysical Journal, 2014 The protein actin exists as both a monomer (G-actin) and polymer (F-actin). There have been more than 80 different crystal structures of G-actin and related homologs over the years, and at least 4 different structures/models for F-actin have been proposed using a combination of techniques.
David Sept +2 more
openaire +2 more sources
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
STORMing towards a clear picture of the cytoskeleton in neurons
eLife, 2015 Super-resolution microscopy has shed new light on the formation of the actin-spectrin network in neurons.
Emerson Stewart, Kang Shen
doaj +1 more source