Results 111 to 120 of about 316,202 (350)

Unlocking the Power of Quercetin‐Encapsulated Mesoporous Bioactive Glass Nanoparticles: A Multifunctional Approach to Bone Regeneration

Advanced Engineering Materials, EarlyView.
Mesoporous bioactive glass nanoparticles (MBGNs) are investigated for bone regeneration given their remarkable structural and functional properties. MBGNs are functionalized with Mn and Cu and incorporated with quercetin, a natural flavonoid exhibiting antioxidant, anti‐inflammatory, and antimicrobial properties.
Giovanni Lo Bello, Qaisar Nawaz, Pier Francesco Ferrari, Laura Pastorino, Roberto Raiteri, Aldo R. Boccaccini   +5 more
wiley   +1 more source

Profilin as a regulator of the membrane-actin cytoskeleton interface in plant cells

Frontiers in Plant Science, 2013
Membrane structures and cytoskeleton dynamics are intimately inter-connected in the eukaryotic cell. Recently, the molecular mechanisms operating at this interface have been progressively addressed.
Tiantian eSun, Shanwei eLi, Haiyun eRen
doaj   +1 more source

A non-conserved amino acid variant regulates differential signalling between human and mouse CD28 [PDF]

, 2018
CD28 superagonistic antibodies (CD28SAb) can preferentially activate and expand immunosuppressive regulatory T cells (Treg) in mice. However, pre-clinical trials assessing CD28SAbs for the therapy of autoimmune diseases reveal severe systemic ...
Alarcon, Balbino, Borroto, Aldo, Campese, Antonio F., Caristi, Silvana, Favre, Cédric, Grazioli, Paola, Kunkl, Martina, Mastrogiovanni, Marta, Muscolini, Michela, Nunès, Jacques A., Porciello, Nicla, Screpanti, Isabella, Spadaro, Francesca, Tuosto, Loretta   +13 more
core   +5 more sources

Patterning the Void: Combining L‐Systems with Archimedean Tessellations as a Perspective for Tissue Engineering Scaffolds

Advanced Functional Materials, EarlyView.
This study introduces a novel multi‐scale scaffold design using L‐fractals arranged in Archimedean tessellations for tissue regeneration. Despite similar porosity, tiles display vastly different tensile responses (1–100 MPa) and deformation modes. In vitro experiments with hMSCs show geometry‐dependent growth and activity. Over 55 000 tile combinations
Maria Kalogeropoulou, Kenny A. van Kampen, Pierpaolo Fucile, Carlos Mota, Lorenzo Moroni   +4 more
wiley   +1 more source

3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research

Advanced Functional Materials, EarlyView.
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram, Majd Machour, Janette Zavin, Roy Meretzki, Reut Lev‐Ari, Shulamit Levenberg   +5 more
wiley   +1 more source

WASP-Arp2/3-dependent actin polymerization influences fusogen localization during cell-cell fusion in Caenorhabditis elegans embryos

Biology Open, 2017
Cell-cell fusion is essential for development and physiology. Actin polymerization was implicated in the Caenorhabditis elegans fusogen EFF-1 engagement in a reconstituted Drosophila cell culture system, and the actin-binding protein spectraplakin links ...
Yan Zhang, Yihong Yang, Zhiwen Zhu, Guangshuo Ou   +3 more
doaj   +1 more source

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

Data from A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells

, 2023
Justine Stehn, Nikolas K. Haass, Teresa Bonello, Melissa Desouza, Gregg Kottyan, Herbert Treutlein, Jun Zeng, Paula R.B.B. Nascimento, Vanessa B. Sequeira, Tanya L. Butler, Munif Allanson, Thomas Fath, Timothy A. Hill, Adam McCluskey, Galina Schevzov, Stephen J. Palmer, Edna C. Hardeman, David S. Winlaw, Vivienne E. Reeve, Ian Dixon, Wolfgang Weninger, Timothy P. Cripe, Peter W. Gunning   +22 more
openalex   +1 more source

Implementation of Drug‐Induced Rhabdomyolysis and Acute Kidney Injury in Microphysiological System

Advanced Functional Materials, EarlyView.
A modular Muscle–Kidney proximal tubule‐on‐a‐chip integrates 3D skeletal muscle and renal proximal tubule tissues to model drug‐induced rhabdomyolysis and acute kidney injury. The coculture system enables dynamic tissue interaction, functional contraction monitoring, and quantification of nephrotoxicity, revealing drug side effect‐induced metabolic ...
Jaesang Kim, Zhuo Feng Lee, Gi‐Dong Sim, Sejoong Kim, Jessie S. Jeon   +4 more
wiley   +1 more source

Effects of Estetrol on Migration and Invasion in T47-D Breast Cancer Cells through the Actin Cytoskeleton [PDF]

, 2014
Maria Silvia Giretti, Maria Magdalena Montt Guevara, Elena Cecchi, Paolo Mannella, G. Palla, Stefania Spina, Guja Bernacchi, Silvia Di Bello, Andrea Riccardo Genazzani, Alessandro D. Genazzani, Tommaso Simoncini   +10 more
openalex   +1 more source