Results 71 to 80 of about 625,356 (301)
The dynamic status of actin in the regulation of environmental sensing and homeostatic control in Saccharomyces cerevisiae [PDF]
, 2014 Actin is a highly conserved protein in eukaryotes which forms dynamic cytoskeletal structures. Rapid remodeling of actin filaments is important for the regulation of a broad range of critical cellular processes.
Smethurst, Daniel George Jan
core
RNA-dependent association with myosin IIA promotes F-actin-guided trafficking of the ELAV-like protein HuR to polysomes [PDF]
, 2013 The role of the mRNA-binding protein human antigen R (HuR) in stabilization and translation of AU-rich elements (ARE) containing mRNAs is well established.
Eberhardt, Wolfgang +3 more
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Медицинская иммунология, 2017 There is a growing body of data about the cytopathic effect of bacterial arginine deiminase on human endothelial cells, but the precise mechanisms of endothelial dysfunction caused by the activity of the enzyme remain poorly understood.
E. A. Starikova +5 more
doaj +1 more source
Cell, 2016 Summary The Phosphoinositide 3-Kinase (PI3K) pathway regulates multiple steps in glucose metabolism but also cytoskeletal functions, such as cell movement and attachment.
Hai Hu +17 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Effects of F/G-actin ratio and actin turn-over rate on NADPH oxidase activity in microglia
BMC Immunology, 2010 Background Most in vivo studies that have addressed the role of actin dynamics in NADPH oxidase function in phagocytes have used toxins to modulate the polymerization state of actin and mostly effects on actin has been evaluated by end point measurements
Rasmussen Izabela +5 more
doaj +1 more source
A novel function of twins, B subunit of protein phosphatase 2A, in regulating actin polymerization. [PDF]
PLoS ONE, 2017 Actin is an important component of the cytoskeleton and its polymerization is delicately regulated by several kinases and phosphatases. Heterotrimeric protein phosphatase 2A (PP2A) is a potent phosphatase that is crucial for cell proliferation, apoptosis,
Po-An Yeh, Ching-Jin Chang
doaj +1 more source
Oxidation and reduction of actin: Origin, impact in vitro and functional consequences in vivo
European Journal of Cell Biology, 2022 Actin is among the most abundant proteins in eukaryotic cells and assembles into dynamic filamentous networks regulated by many actin binding proteins. The actin cytoskeleton must be finely tuned, both in space and time, to fulfill key cellular functions
Clémentine Rouyère +3 more
doaj +1 more source
NAA80 is actin’s N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance More than 80% of human proteins are N-terminal (Nt)–acetylated during translation. In contrast, actin, the most abundant protein in the cytoplasm of animal cells, is Nt-acetylated posttranslationally and following a unique multistep ...
Adrian Drazic +12 more
semanticscholar +1 more source