Results 61 to 70 of about 131,481 (208)

Effects of F/G-actin ratio and actin turn-over rate on NADPH oxidase activity in microglia

BMC Immunology, 2010
Background Most in vivo studies that have addressed the role of actin dynamics in NADPH oxidase function in phagocytes have used toxins to modulate the polymerization state of actin and mostly effects on actin has been evaluated by end point measurements
Rasmussen Izabela, Pedersen Line H, Byg Luise, Suzuki Kazuhiro, Sumimoto Hideki, Vilhardt Frederik   +5 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Nanoclustering as a dominant feature of plasma membrane organization [PDF]

, 2014
Early studies have revealed that some mammalian plasma membrane proteins exist in small nanoclusters. The advent of super-resolution microscopy has corroborated and extended this picture, and led to the suggestion that many, if not most, membrane ...
Cambi, Alessandra, García-Parajo, María F., Jacobson, Ken, Thomoson, Nancy, Torreño-Piña, Juan A.   +4 more
core   +5 more sources

In vivo reorganization of the actin cytoskeleton in leaves of Nicotiana tabacum L. transformed with plastin-GFP. Correlation with light-activated chloroplast responses

BMC Plant Biology, 2009
Background The actin cytoskeleton is involved in the responses of plants to environmental signals. Actin bundles play the role of tracks in chloroplast movements activated by light.
Anielska-Mazur Anna, Bernaś Tytus, Gabryś Halina   +2 more
doaj   +1 more source

Shielding of actin by the endoplasmic reticulum impacts nuclear positioning

Nature Communications, 2022
The nucleus connects to the actin cytoskeleton for nuclear movement in migrating cells. Here, the authors show that the endoplasmic reticulum shields actin cables to generate asymmetric nucleo-cytoskeleton connections for nuclear positioning.
Cátia Silva Janota, Andreia Pinto, Anna Pezzarossa, Pedro Machado, Judite Costa, Pedro Campinho, Cláudio A. Franco, Edgar R. Gomes   +7 more
doaj   +1 more source

Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies

Frontiers in Cell and Developmental Biology, 2021
The actin cytoskeleton is composed of dynamic filament networks that build adaptable local architectures to sustain nearly all cellular activities in response to a myriad of stimuli. Although the function of numerous players that tune actin remodeling is
Loïc Dupré, Loïc Dupré, Loïc Dupré, Kaan Boztug, Kaan Boztug, Kaan Boztug, Kaan Boztug, Kaan Boztug, Laurène Pfajfer, Laurène Pfajfer, Laurène Pfajfer, Laurène Pfajfer   +11 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Microvibration stimuli causes localized depolymerization of the actin cytoskeleton of osteoblasts around the nucleus

Journal of Biomechanical Science and Engineering
Reports have indicated that microvibration stimulation activates bone remodeling and promotes bone formation. However, the mechanism by which microvibration stimulation facilitates bone formation remains incompletely understood, and it is unclear how ...
Katsuya SATO, Satoshi ODA
doaj   +1 more source

Super-Resolution Microscopy Reveals the Native Ultrastructure of the Erythrocyte Cytoskeleton

Cell Reports, 2018
Summary: The erythrocyte cytoskeleton is a textbook prototype for the submembrane cytoskeleton of metazoan cells. While early experiments suggest a triangular network of actin-based junctional complexes connected by ∼200-nm-long spectrin tetramers, later
Leiting Pan, Rui Yan, Wan Li, Ke Xu
doaj   +1 more source

Arabidopsis ADF5 Acts as a Downstream Target Gene of CBFs in Response to Low-Temperature Stress

Frontiers in Cell and Developmental Biology, 2021
Low temperature is a major adverse environment that affects normal plant growth. Previous reports showed that the actin cytoskeleton plays an important role in the plant response to low-temperature stress, but the regulatory mechanism of the actin ...
Pan Zhang, Dong Qian, Changxin Luo, Yingzhi Niu, Tian Li, Chengying Li, Yun Xiang, Xinyu Wang, Yue Niu   +8 more
doaj   +1 more source