Dynamical features of smooth muscle actin pathological mutants: The arginine-257(258)-Cysteine cases [PDF]
Computational and Structural Biotechnology JournalThe R257(8)C mutation in smooth muscle actins, ACTG2 and ACTA2, is the most frequent cause of severe genetic diseases: namely, visceral myopathy, and familial thoracic aortic aneurysms and dissections, which respectively, stem from impairment of the ...
F. Chiappori +4 more
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Electrochemically modulated single-molecule localization microscopy for in vitro imaging cytoskeletal protein structures [PDF]
NanophotonicsA new concept of electrochemically modulated single-molecule localization super-resolution imaging is developed. Applications of single-molecule localization super-resolution microscopy have been limited due to insufficient availability of qualified ...
Lei Chenghong, Hu Dehong
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High-resolution yeast actin structures indicate the molecular mechanism of actin filament stiffening by cations [PDF]
Communications ChemistryActin filament assembly and the regulation of its mechanical properties are fundamental processes essential for eukaryotic cell function. Residue E167 in vertebrate actins forms an inter-subunit salt bridge with residue K61 of the adjacent subunit ...
Xiao-Ping Xu +8 more
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Rapamycin-filgrastim combination therapy ameliorates portal hypertension-induced splenomegaly: Role of β actin and S100A9 proteins modulation [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Thioacetamide (TAA) was administered to induce an animal model of liver disease with secondary splenomegaly to assess the mechanisms underlying the effects of rapamycin and filgrastim when taken separately or in combination on the ...
Shaimaa Abdelrahman +2 more
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Elevated barometric pressure suppresses cell proliferation by delaying the G2/M phase and weakening integrin-mediated cell adhesion and actin assembly [PDF]
Archives of Biological Sciences, 2023 Human cells are continuously exposed to various stress factors in their physiological environment. Evidence suggests that certain mechanical stress can affect cell cycle progression and cell proliferation. However, the signaling pathways involved in this
Son Gwang-ic +5 more
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Antioxidants, 2021 The human mutant cardiac α-actins p.A295S or p.R312H and p.E361G, correlated with hypertrophic or dilated cardiomyopathy, respectively, were expressed by the baculovirus/Sf21 insect cell system and purified to homogeneity.
Constanze Erdmann +10 more
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Dental Research Journal, 2021 Background: Odontogenic cysts and tumors exhibit varying degrees of aggressiveness in their biological behavior. Odontogenic keratocyst (OKC), dentigerous cyst (DC), ameloblastoma are most common odontogenic cysts and tumors to occur in the oral cavity ...
V V Anusai +5 more
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Scientific Reports, 2021 We have recently found that β-actin-like protein 2 (actbl2) forms complexes with gelsolin in human melanoma cells and can polymerize. Phylogenetic and bioinformatic analyses showed that actbl2 has a common origin with two non-muscle actins, which share a
Natalia Malek +5 more
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An In Silico Investigation of the Molecular Interactions between Volatile Anesthetics and Actin
Pharmaceuticals, 2023 Volatile anesthetics (VAs) are medicinal chemistry compounds commonly used to enable surgical procedures for patients who undergo painful treatments and can be partially or fully sedated, remaining in an unconscious state during the operation.
Barbara Truglia +7 more
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Immunohistochemical analysis of α-SMA and GFAP expression in liver stellate cells [PDF]
Vojnosanitetski Pregled, 2006 Background/Aim. Liver stellate cells play an important role in hepatic fibrosis, and its progression to cirrhosis. These cells show immunoreactivity with different monoclonal antibodies amongst which the commonest are α-smooth muscle actin (α-SMA) and ...
Tomanović Nada +2 more
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