Structural differences explain diverse functions of Plasmodium actins.
PLoS Pathogens, 2014 Actins are highly conserved proteins and key players in central processes in all eukaryotic cells. The two actins of the malaria parasite are among the most divergent eukaryotic actins and also differ from each other more than isoforms in any other ...
Juha Vahokoski +11 more
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Emerging Functions of Actins and Actin Binding Proteins in Trypanosomatids
Frontiers in Cell and Developmental Biology, 2020 Actin is the major protein constituent of the cytoskeleton that performs wide range of cellular functions. It exists in monomeric and filamentous forms, dynamics of which is regulated by a large repertoire of actin binding proteins. However, not much was
Chhitar M. Gupta +4 more
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Dynamical features of smooth muscle actin pathological mutants: The arginine-257(258)-Cysteine cases [PDF]
Computational and Structural Biotechnology JournalThe R257(8)C mutation in smooth muscle actins, ACTG2 and ACTA2, is the most frequent cause of severe genetic diseases: namely, visceral myopathy, and familial thoracic aortic aneurysms and dissections, which respectively, stem from impairment of the ...
F. Chiappori +4 more
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The actinome of Dictyostelium discoideum in comparison to actins and actin-related proteins from other organisms. [PDF]
PLoS ONE, 2008 Actin belongs to the most abundant proteins in eukaryotic cells which harbor usually many conventional actin isoforms as well as actin-related proteins (Arps).
Jayabalan M Joseph +8 more
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Electrochemically modulated single-molecule localization microscopy for in vitro imaging cytoskeletal protein structures [PDF]
NanophotonicsA new concept of electrochemically modulated single-molecule localization super-resolution imaging is developed. Applications of single-molecule localization super-resolution microscopy have been limited due to insufficient availability of qualified ...
Lei Chenghong, Hu Dehong
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High-resolution yeast actin structures indicate the molecular mechanism of actin filament stiffening by cations [PDF]
Communications ChemistryActin filament assembly and the regulation of its mechanical properties are fundamental processes essential for eukaryotic cell function. Residue E167 in vertebrate actins forms an inter-subunit salt bridge with residue K61 of the adjacent subunit ...
Xiao-Ping Xu +8 more
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Rapamycin-filgrastim combination therapy ameliorates portal hypertension-induced splenomegaly: Role of β actin and S100A9 proteins modulation [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Thioacetamide (TAA) was administered to induce an animal model of liver disease with secondary splenomegaly to assess the mechanisms underlying the effects of rapamycin and filgrastim when taken separately or in combination on the ...
Shaimaa Abdelrahman +2 more
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Elevated barometric pressure suppresses cell proliferation by delaying the G2/M phase and weakening integrin-mediated cell adhesion and actin assembly [PDF]
Archives of Biological Sciences, 2023 Human cells are continuously exposed to various stress factors in their physiological environment. Evidence suggests that certain mechanical stress can affect cell cycle progression and cell proliferation. However, the signaling pathways involved in this
Son Gwang-ic +5 more
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Science Advances, 2023 Protein filaments are used in myriads of ways to organize other molecules within cells. Some filament-forming proteins couple the hydrolysis of nucleotides to their polymerization cycle, thus powering the movement of other molecules.
J. Wagstaff +6 more
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Annals of the New York Academy of Sciences, 2022 The integrity and functions of epithelial barriers depend on the formation of adherens junctions (AJs) and tight junctions (TJs). A characteristic feature of AJs and TJs is their association with the cortical cytoskeleton composed of actin filaments and ...
A. Ivanov +3 more
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