Dynamical features of smooth muscle actin pathological mutants: The arginine-257(258)-Cysteine cases [PDF]
Computational and Structural Biotechnology JournalThe R257(8)C mutation in smooth muscle actins, ACTG2 and ACTA2, is the most frequent cause of severe genetic diseases: namely, visceral myopathy, and familial thoracic aortic aneurysms and dissections, which respectively, stem from impairment of the ...
F. Chiappori +4 more
doaj +2 more sources
Structural Differences Explain Diverse Functions of Plasmodium Actins
PLoS Pathogens, 2014 Actins are highly conserved proteins and key players in central processes in all eukaryotic cells. The two actins of the malaria parasite are among the most divergent eukaryotic actins and also differ from each other more than isoforms in any other ...
Ambroise Desfosses +2 more
exaly +3 more sources
Naa80 is required for actin N-terminal acetylation and normal hearing in zebrafish [PDF]
Life Science AllianceA zebrafish knockout model of the N-terminal acetyltransferase Naa80 demonstrates that this enzyme is required for actin N-terminal acetylation and normal inner ear development. Actin is a critical component of the eukaryotic cytoskeleton.
Rasmus Ree +6 more
doaj +2 more sources
The Actinome of Dictyostelium discoideum in Comparison to Actins and Actin-Related Proteins from Other Organisms [PDF]
PLoS ONE, 2008 Actin belongs to the most abundant proteins in eukaryotic cells which harbor usually many conventional actin isoforms as well as actin-related proteins (Arps).
Petra Fey +2 more
exaly +2 more sources
Electrochemically modulated single-molecule localization microscopy for in vitro imaging cytoskeletal protein structures [PDF]
NanophotonicsA new concept of electrochemically modulated single-molecule localization super-resolution imaging is developed. Applications of single-molecule localization super-resolution microscopy have been limited due to insufficient availability of qualified ...
Lei Chenghong, Hu Dehong
doaj +2 more sources
Rapamycin-filgrastim combination therapy ameliorates portal hypertension-induced splenomegaly: Role of β actin and S100A9 proteins modulation [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Thioacetamide (TAA) was administered to induce an animal model of liver disease with secondary splenomegaly to assess the mechanisms underlying the effects of rapamycin and filgrastim when taken separately or in combination on the ...
Shaimaa Abdelrahman +2 more
doaj +1 more source
Elevated barometric pressure suppresses cell proliferation by delaying the G2/M phase and weakening integrin-mediated cell adhesion and actin assembly [PDF]
Archives of Biological Sciences, 2023 Human cells are continuously exposed to various stress factors in their physiological environment. Evidence suggests that certain mechanical stress can affect cell cycle progression and cell proliferation. However, the signaling pathways involved in this
Son Gwang-ic +5 more
doaj +1 more source
Antioxidants, 2021 The human mutant cardiac α-actins p.A295S or p.R312H and p.E361G, correlated with hypertrophic or dilated cardiomyopathy, respectively, were expressed by the baculovirus/Sf21 insect cell system and purified to homogeneity.
Constanze Erdmann +10 more
doaj +1 more source
Dental Research Journal, 2021 Background: Odontogenic cysts and tumors exhibit varying degrees of aggressiveness in their biological behavior. Odontogenic keratocyst (OKC), dentigerous cyst (DC), ameloblastoma are most common odontogenic cysts and tumors to occur in the oral cavity ...
V V Anusai +5 more
doaj +1 more source
Scientific Reports, 2021 We have recently found that β-actin-like protein 2 (actbl2) forms complexes with gelsolin in human melanoma cells and can polymerize. Phylogenetic and bioinformatic analyses showed that actbl2 has a common origin with two non-muscle actins, which share a
Natalia Malek +5 more
doaj +1 more source