Results 91 to 100 of about 243,847 (379)

Relaxed and active thin filament structures; a new structural basis for the regulatory mechanism [PDF]

, 2017
The structures of muscle thin filaments reconstituted using skeletal actin and cardiac troponin and tropomyosin have been determined with and without bound Ca2+ using electron microscopy and reference-free single particle analysis.
Morris, Edward, Paul, Danielle, Squire, John   +2 more
core   +1 more source

Extent of myosin penetration within the actin cortex regulates cell surface mechanics [PDF]

, 2021
Binh An Truong Quang, Ruby Peters, Davide A. D. Cassani, Priyamvada Chugh, Andrew G. Clark, Meghan Agnew, Guillaume Charras, Ewa K. Paluch   +7 more
openalex   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

シロイヌナズナアクチンアイソフォームの分子細胞生物学的研究 [PDF]

, 2018
この博士論文は内容の要約のみの公開（または一部非公開）になっています筑波大学 (University of Tsukuba ...
KIJIMA Saku, 貴嶋 紗久
core   +1 more source

Dynamic Mechanisms of Cell Rigidity Sensing: Insights from a Computational Model of Actomyosin Networks [PDF]

, 2012
Cells modulate themselves in response to the surrounding environment like substrate elasticity, exhibiting structural reorganization driven by the contractility of cytoskeleton. The cytoskeleton is the scaffolding structure of eukaryotic cells, playing a
A Engler, A Ganz, A Saez, A Zemel, A Zemel, AJ Engler, AJ Engler, AK Blakney, AV Hill, B Ladoux, B Martinac, C Kung, C Ruegg, Carlos Borau, CM Lo, D Mitrossilis, D Mitrossilis, DE Discher, DE Rassier, F Bordeleau, FH Silver, IB Bischofs, JA Astrom, José Manuel García-Aznar, KD Webster, L Richert, L Trichet, M Ghibaudo, M Kovacs, MH Zaman, ML Gardel, P Marcq, RJ Pelham, Roger D. Kamm, S Munevar, S Walcott, SY Tee, T Kim, T Kim, T Kim, T McMahon, Taeyoon Kim, Tamara Bidone, US Schwarz, US Schwarz, Wilbur Lam, Y Dou, Y Ren   +47 more
core   +4 more sources

Actin bundle architecture and mechanics regulate myosin II force generation [PDF]

, 2021
Kimberly L. Weirich, Samantha Stam, Edwin Munro, Margaret L. Gardel   +3 more
openalex   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

α-Smooth Muscle Actin and ACTA2 Gene Expressions in Vasculopathies

Brazilian Journal of Cardiovascular Surgery, 2015
α-smooth muscle actin, encoded by ACTA2 gene, is an isoform of the vascular smooth muscle actins, typically expressed in the vascular smooth muscle cells contributing to vascular motility and contraction. ACTA2 gene mutations cause a diversity of diffuse
Shi-Min Yuan
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Dipotassium 4,4′-(hexane-3,4-diyl)bis(benzenesulfonate) dihydrate

Acta Crystallographica Section E, 2008
The anion of the title compound, also called sygethin dihydrate, 2K+·C18H20O6S22−·2H2O, has crystallographic inversion symmetry. The K+ cation is surrounded by eight O atoms in a distorted cubic coordination geometry, forming extended K ...
Liana Orola, Mikelis V. Veidis, Sergey Belyakov, Andris Actins   +3 more
doaj   +1 more source