Evolutionarily divergent, unstable filamentous actin is essential for gliding motility in apicomplexan parasites. [PDF]
PLoS Pathogens, 2011 Apicomplexan parasites rely on a novel form of actin-based motility called gliding, which depends on parasite actin polymerization, to migrate through their hosts and invade cells.
Kristen M Skillman +5 more
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Different translation dynamics of β- and γ-actin regulates cell migration
eLife, 2021 β- and γ-cytoplasmic actins are ubiquitously expressed in every cell type and are nearly identical at the amino acid level but play vastly different roles in vivo. Their essential roles in embryogenesis and mesenchymal cell migration critically depend on
Pavan Vedula +7 more
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Structure and function of Plasmodium actin II in the parasite mosquito stages.
PLoS Pathogens, 2023 Actins are filament-forming, highly-conserved proteins in eukaryotes. They are involved in essential processes in the cytoplasm and also have nuclear functions.
Andrea J Lopez +10 more
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PLoS ONE, 2014 The pressure tolerance of monomeric α-actin proteins from the deep-sea fish Coryphaenoides armatus and C. yaquinae was compared to that of non-deep-sea fish C.
Nobuhiko Wakai +3 more
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Frontiers in Pharmacology, 2022 The cytoplasmic actin isoforms (β- and γ-actins) contribute greatly to cellular processes such as cel-cell and cell-matrix interactions, as well as cell polarization, motility and division. Distinct isoforms modulations are linked to serious pathologies,
V. B. Dugina +3 more
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Structural differences explain diverse functions of Plasmodium actins.
PLoS Pathogens, 2014 Actins are highly conserved proteins and key players in central processes in all eukaryotic cells. The two actins of the malaria parasite are among the most divergent eukaryotic actins and also differ from each other more than isoforms in any other ...
Juha Vahokoski +11 more
doaj +1 more source
Cytoplasmic actin is an extracellular insect immune factor which is secreted upon immune challenge and mediates phagocytosis and direct killing of bacteria, and is a Plasmodium Antagonist. [PDF]
PLoS Pathogens, 2015 Actin is a highly versatile, abundant, and conserved protein, with functions in a variety of intracellular processes. Here, we describe a novel role for insect cytoplasmic actin as an extracellular pathogen recognition factor that mediates antibacterial ...
Simone L Sandiford +5 more
doaj +1 more source
Catastrophic disassembly of actin filaments via Mical-mediated oxidation. [PDF]
, 2017 Actin filament assembly and disassembly are vital for cell functions. MICAL Redox enzymes are important post-translational effectors of actin that stereo-specifically oxidize actin's M44 and M47 residues to induce cellular F-actin disassembly.
Ge, Peng +6 more
core +3 more sources
Spectrins in Axonal Cytoskeletons: Dynamics Revealed by Extensions and Fluctuations [PDF]
, 2014 The macroscopic properties, the properties of individual components and how those components interact with each other are three important aspects of a composited structure.
Carmo M. +3 more
core +1 more source
Localization of actin in Dictyostelium amebas by immunofluorescence [PDF]
, 1977 Antibody prepared against avian smooth muscle actin has been used to localize actin in the slime mold, Dictyostelium discoideum. The distribution of actin in migrating cells is different from that in feeding cells.
Eckert, Barry S., Lazarides, Elias
core +2 more sources