Results 1 to 10 of about 693,055 (312)

Activating transcription factor 4-dependent hsa-miR-663a transcription mediates mTORC1/p70S6K1 signaling underleucine deprivation [PDF]

Frontiers in Nutrition, 2022
The mechanistic target of rapamycin complex 1 (mTORC1) is involved in nutrient-induced signaling and is a master regulator of cell growth and metabolism.
Junki Yamamura, Sihui Ma, Huijuan Jia, Hisanori Kato   +3 more
doaj   +6 more sources

Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase [PDF]

Scientific Reports, 2017
The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1).
Rana J. T. Al-Baghdadi, Inna A. Nikonorova, Emily T. Mirek, Yongping Wang, Jinhee Park, William J. Belden, Ronald C. Wek, Tracy G. Anthony   +7 more
doaj   +7 more sources

Activating transcription factor 4 drives the progression of diabetic cardiac fibrosis [PDF]

ESC Heart Failure, 2023
Aims Diabetic cardiomyopathy (DC) is one of serious complications of diabetic patients. This study investigated the biological function of activating transcription factor 4 (ATF4) in DC.
Yu Li, Qian He, Chao‐Yong He, Chao Cai, Zhen Chen, Jing‐Zhu Duan   +5 more
doaj   +4 more sources

Upregulation of the coagulation factor VII gene during glucose deprivation is mediated by activating transcription factor 4. [PDF]

PLoS ONE, 2012
BACKGROUND: Constitutive production of blood coagulation proteins by hepatocytes is necessary for hemostasis. Stressful conditions trigger adaptive cellular responses and delay processing of most proteins, potentially affecting plasma levels of proteins ...
Katherine R Cronin, Thomas P Mangan, Josephine A Carew   +2 more
doaj   +12 more sources

Role of Activating Transcription Factor 4 in Murine Choroidal Neovascularization Model. [PDF]

Int J Mol Sci, 2021
Neovascular age-related macular degeneration (nAMD) featuring choroidal neovascularization (CNV) is the principal cause of irreversible blindness in elderly people in the world. Integrated stress response (ISR) is one of the intracellular signals to be adapted to various stress conditions including endoplasmic reticulum (ER) stress.
Yasuda H, Tanaka M, Nishinaka A, Nakamura S, Shimazawa M, Hara H.   +5 more
europepmc   +6 more sources

Activating transcription factor 4 regulates stearate-induced vascular calcification [PDF]

Journal of Lipid Research, 2012
Previously, we reported that stearate, a saturated fatty acid, promotes osteoblastic differentiation and mineralization of vascular smooth muscle cells (VSMC).
Masashi Masuda, Tabitha C. Ting, Moshe Levi, Sommer J. Saunders, Shinobu Miyazaki-Anzai, Makoto Miyazaki   +5 more
doaj   +4 more sources

Activating transcription factor-4 promotes mineralization in vascular smooth muscle cells. [PDF]

JCI Insight, 2016
Emerging evidence indicates that upregulation of the ER stress-induced pro-osteogenic transcription factor ATF4 plays an important role in vascular calcification, a common complication in patients with aging, diabetes, and chronic kidney disease (CKD).
Masuda M, Miyazaki-Anzai S, Keenan AL, Shiozaki Y, Okamura K, Chick WS, Williams K, Zhao X, Rahman SM, Tintut Y, Adams CM, Miyazaki M.   +11 more
europepmc   +5 more sources

Activating transcription factor 4: a regulator of stress response in human cancers [PDF]

Frontiers in Cell and Developmental Biology
Activating transcription factor 4 (ATF4) is an adaptive response regulator of metabolic and oxidative homeostasis. In response to cellular stress, ATF4 is activated and functions as a regulator to promote cell adaptation for survival.
Di Wu, Jie Liang
doaj   +4 more sources

Epigallocatechin Gallate Ameliorates Granulosa Cell Developmental via the Eukaryotic Initiation Factor 2 Alpha/Activating Transcription Factor 4 Pathway in Hyperthyroid Female Rats [PDF]

Antioxidants
Follicular development is recognized as a highly complex biological process regulated by multiple factors. Thyroid hormone (TH) is considered one of the key regulators of female reproduction, and its dysregulation can significantly impair follicular ...
Ying Sun, Mingqi Wu, Haoyuan Feng, Yilin Yao, Rui Chen, Yanzhou Yang, Cheng Zhang   +6 more
doaj   +4 more sources

Drosophila melanogaster activating transcription factor 4 regulates glycolysis during endoplasmic reticulum stress. [PDF]

G3 (Bethesda), 2015
AbstractEndoplasmic reticulum (ER) stress results from an imbalance between the load of proteins entering the secretory pathway and the ability of the ER to fold and process them. The response to ER stress is mediated by a collection of signaling pathways termed the unfolded protein response, which plays important roles in development and disease. Here
Lee JE, Oney M, Frizzell K, Phadnis N, Hollien J.   +4 more
europepmc   +6 more sources