Results 121 to 130 of about 17,248,721 (282)

Identification and validation of transcription factors that regulate chromatin dynamics [PDF]

, 2012
Gene expression has to be tightly regulated during all cellular processes. During embryonic development differentiating cells loose their developmental potential and acquire specific functions by activating lineage-specific genes.
Schöler, Anne
core   +1 more source

Xanthohumol inhibits extracellular matrix degradation via the Nrf2/PERK/ATF4/C/EBPβ pathway in osteoarthritis

Türk Biyokimya Dergisi
This study aims to explore the therapeutic potential of Xanthohumol (XH) in mitigating osteoarthritis (OA) progression by inhibiting extracellular matrix (ECM) degradation.
Zheng Tiansheng, Niu Shuo, Zhou Qingluo, Huang Jishang, Yi Jun, Mei Runhong, Yu Xuefeng   +6 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Role of ATF4 in fibroblast proliferation and apoptosis induced by mechanical trauma through the miR−93-3p/Smad7 axis

Stress
Stress urinary incontinence (SUI) is a serious disease for females. This study attempts to explore the role of activating transcription factor 4 (ATF4) in mechanical trauma-induced SUI fibroblast cell proliferation and apoptosis, thereby finding a ...
Wei Li, Haitang Chen, Xueyan Hu, Peifan Yang, Mingmin Liu   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Plant Transcription Factors @ uni-potsdam.de [PDF]

, 2007
We present the Plant Transcription Factor Database (PlnTFDB), and the putative complete set of TFs in the algae _Chlamydomonas reinhardtii_, _Ostreococcus tauri_ and the vascular plants _Oryza sativa_ and _Arabidopsis ...
Slobodan Ruzicic, Ingo Dreyer, Diego Mauricio Riaño-Pachón, Bernd Mueller-Roeber   +3 more
core   +1 more source

Effect of electroacupuncture of “Fengfu” (GV16)and “Taichong” (LR3)on EIF2α-ATF4-GRP78/Bip signaling in substantia nigra of rats with Parkinson's disease

针刺研究, 2019
ObjectiveTo observe the effect of electroacupuncture(EA)on expression of eukaryotic initiation factor 2α(EIF2α),activating transcription factor 4(ATF4),glucose regulator protein-78/immunoglobulin heavy-chainbinding protein(GRP78/Bip)in the substantia ...
MA Jun, WANG Yao, WANG Shu-ju, YUAN Li, LI Ya-nan, YU Ben-lu   +5 more
doaj  

Branched-chain amino acid metabolism disorder promotes the progression of diabetic kidney disease by inducing podocyte apoptosis in glomeruli via activating the mTOR-ATF4-Chop/Trib3 signaling pathway

陆军军医大学学报
Objective To investigate the molecular mechanisms by which branched-chain amino acids (BCAAs) catabolic disorder induces glomerular podocyte injury, and to elucidate its role and mechanism in promoting the pathogenesis of diabetic nephropathy (DN) in a ...
TIAN Wenqi, ZHAO Xiaojuan
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Activating Transcription Factor 4 regulation of radiofrequency radiation-induced ferroptosis in osteoblasts

Electromagnetic Biology and Medicine
Given the ubiquitous presence of radiofrequency (RF) radiation sources in modern environments, concerns have been raised regarding their cytotoxic effects on osteoblasts and potential implications for skeletal health. This study investigated the molecular mechanisms underlying these effects, focusing on ferroptosis, a form of regulated cell death ...
Haiying, Wang, Weijin, Zou, Caihua, Ding, Yi, Cao   +3 more
openaire   +2 more sources