Regulation of cellular immunity by activating transcription factor 4. [PDF]
Immunol Lett, 2020 Activating transcription factor 4 (ATF4) is a DNA binding transcription factor belonging to the family of basic Leucine zipper proteins. ATF4 can be activated in response to multiple cellular stress signals including endoplasmic reticulum stress in the event of improper protein folding or oxidative stress because of mitochondrial dysfunction as well as
Mukherjee D +3 more
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Activating transcription factor 4 protects mice against sepsis-induced intestinal injury by regulating gut-resident macrophages differentiation [PDF]
Chinese Medical Journal, 2022 . Background:. Gut-resident macrophages (gMacs) supplemented by monocytes-to-gMacs differentiation play a critical role in maintaining intestinal homeostasis. Activating transcription factor 4 (ATF4) is involved in immune cell differentiation.
Zhenliang Wen +13 more
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Activating transcription factor 4 mediates adaptation of human glioblastoma cells to hypoxia and temozolomide [PDF]
Scientific Reports, 2021 The integrated stress response (ISR) is a central cellular adaptive program that is activated by diverse stressors including ER stress, hypoxia and nutrient deprivation to orchestrate responses via activating transcription factor 4 (ATF4).
Nadja I. Lorenz +7 more
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The dual role of activating transcription factor 4: from cellular stress sentinel to cardiovascular disease intervention [PDF]
PeerJAs the master orchestrator of integrated stress response, activating transcription factor 4 (ATF4) operates as a central molecular switch that directs cellular fate toward survival or death by regulating genes associated with oxidative stress ...
Yaping Wang +3 more
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Sestrin2 Regulates Endoplasmic Reticulum Stress-Dependent Ferroptosis to Engage Pulmonary Fibrosis by Nuclear Factor Erythroid 2-Related Factor 2/Activating Transcription Factor 4 (NRF2/ATF4) [PDF]
Journal of Immunology Research, 2023 Pulmonary fibrosis (PF) can lead to chronic inflammation, the destruction of alveoli and irreversible lung damage. Sestrin2 is a highly protective stress-inducible protein that is involved in the cell response to various stress factors and the regulation
Zhaoxing Dong +5 more
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Activating Transcription Factor 4 (ATF4) Modulates Post-synaptic Development and Dendritic Spine Morphology [PDF]
Frontiers in Cellular Neuroscience, 2014 The ubiquitously expressed activating transcription factor 4 (ATF4) has been variably reported to either promote or inhibit neuronal plasticity and memory.
Jin eLiu +3 more
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Brain-Derived Neurotrophic Factor Elevates Activating Transcription Factor 4 (ATF4) in Neurons and Promotes ATF4-Dependent Induction of Sesn2 [PDF]
Frontiers in Molecular Neuroscience, 2018 Activating transcription factor 4 (ATF4) plays important physiologic roles in the brain including regulation of learning and memory as well as neuronal survival and death.
Jin Liu +7 more
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Activating transcription factor 4 plays a major role in shaping the transcriptional response to isoginkgetin in HCT116 cells [PDF]
Scientific ReportsActivating transcription factor 4 (ATF4) plays a central role in the integrated stress response (ISR) and one overlapping branch of the unfolded protein response (UPR).
Erin van Zyl +4 more
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Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells [PDF]
Frontiers in Cell and Developmental Biology, 2021 Excessive reactive oxygen species (ROS) and apoptosis in nucleus pulposus (NP) cells accelerate the process of intervertebral disc degeneration (IDD). Here, we integrated pathological samples and in vitro and in vivo framework to investigate the impact ...
Junping Bao +10 more
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Impact of activating transcription factor 4 signaling on lipogenesis in HepG2 cells
Molecular Medicine Reports, 2016 Non-alcoholic fatty liver disease (NAFLD) is a rapidly growing health threat that has previously been associated with lipogenesis. The direct effect of endoplasmic reticulum stress (ERS) inhibition on the induction of lipogenesis has not been investigated in hepatocytes in vitro.
Luping Ren +7 more
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