Results 211 to 220 of about 495,141 (240)

Regulation of FGF-4 Enhancer Activity by Transcription Factor NF-Y

Biochemical and Biophysical Research Communications, 1995
Regulation of FGF-4 gene expression is controlled both by elements in the promoter and by an enhancer domain located in the untranslated region of the third exon. We have determined that transcription factor NF-Y binds to the FGF-4 promoter. We further show by mutational analysis that binding of NF-Y is essential for FGF-4 enhancer activity but has ...
M, Bryans, J M, Lucas, T J, Knobloch, N M, Wilkie, J C, Lang   +4 more
openaire   +2 more sources

SUMOylation can regulate the activity of ETS-like transcription factor 4

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2010
ETS-like transcription factor 4 (ELK4) (a.k.a. serum response factor accessory protein 1) belongs to the ternary complex factor (TCF) subfamily of E twenty-six (ETS) domain transcription factors. Compared to the other TCF subfamily members, ELK1 and ELK3 (NET), there is limited information of the mechanisms regulating the ELK4 activity.
Sanna, Kaikkonen, Harri, Makkonen, Miia, Rytinki, Jorma J, Palvimo   +3 more
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Effects of activating transcription factor 4 deficiency on carbohydrate and lipid metabolism in mammals

IUBMB Life, 2012
AbstractIt has been shown that the mammalian activating transcription factor 4 (ATF4) is involved in many different physiological events, such as eye development, stress response, learning, and memory. However, several recent studies have demonstrated that ATF4 also plays an important role in the regulation of lipid and glucose metabolism, energy ...
Chunxia, Wang, Feifan, Guo
openaire   +2 more sources

Activating Transcription Factor 4 Modulates BDNF Release from Microglial Cells

Journal of Molecular Neuroscience, 2013
Pathogenic pain is a common sign of many diseases. The mechanism is unclear. Activating transcription factor 4 (ATF4) plays a critical role in cell activation. Brain-derived neurotrophic factor (BDNF) is an important molecule in pathogenic pain. This study aims to investigate the role of ATF4 in inducing BDNF release from microglial cells.
Pengling, Sun, Xiangnan, Li, Chengwen, Chen, Qianbo, Chen, Qing, Ouyang, Fangting, Liu, Zhenghua, Xiang, Hongbin, Yuan   +7 more
openaire   +2 more sources

Short Communication: Activating Transcription Factor 4 (ATF4) Promotes HIV Type 1 Activation

AIDS Research and Human Retroviruses, 2012
Activating transcription factor 4 (ATF4) is a central factor in the cellular response to multiple stresses, including altered metabolic conditions, anoxia and hypoxia, and redox stress. ATF4 is triggered by endoplasmic reticulum stress and consequent unfolded protein response.
Elisabetta, Caselli, Sabrina, Benedetti, Valentina, Gentili, Jessica, Grigolato, Dario, Di Luca   +4 more
openaire   +2 more sources

Activating Transcription Factor 4 (ATF4) promotes HIV-1 activation

2012
Activating Transcription Factor 4 (ATF4) is a central factor in the cellular response to multiple stresses, including altered metabolic conditions, anoxia and hypoxia, redox stress. ATF4 is triggered by endoplasmic reticulum stress and consequent unfolded protein response.
CASELLI, Elisabetta, BENEDETTI, Sabrina, GENTILI, Valentina, GRIGOLATO, Jessica, DI LUCA, Dario   +4 more
openaire   +1 more source

Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation

Biochemical Journal, 2012
Nutrient deprivation or starvation frequently correlates with amino acid limitation. Amino acid starvation initiates a signal transduction cascade starting with the activation of the kinase GCN2 (general control non-derepressible 2) phosphorylation of eIF2 (eukaryotic initiation factor 2), global protein synthesis reduction and increased ATF4 ...
Ana Luísa, De Sousa-Coelho, Pedro F, Marrero, Diego, Haro   +2 more
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Interaction Between Activating Transcription Factor 4 and Interleukin 6 Dictates Osteoclast Differentiation and Activity

The FASEB Journal
ABSTRACT Osteoclast functioning determines homeostasis of bone texture, healing speed after bone injury, and integrity after bone remodeling. Osteoclastogenesis is tightly controlled by transcriptional factors and cytokine‐mediated signaling.
Shasha Tu, Sijun Liu, Mengmeng Duan, Jiazhou Li, Li Zhang, Jie Ren, Ting Zhao, Jing Xie, Xiaoheng Liu   +8 more
openaire   +2 more sources

Intermedin/adrenomedullin 2 is a stress-inducible gene controlled by activating transcription factor 4

Gene, 2016
Intermedin or adrenomedullin 2 is a set of calcitonin-related peptides with a putative tumor angiogenesis promoting activity that are formed by proteolytic processing of the ADM2 gene product. It has been proposed that the ADM2 gene is regulated by the estrogen response element (ERE) and hypoxia response elements (HRE) found within its promoter region.
Irina E. Kovaleva, Alisa A. Garaeva, Peter M. Chumakov, Alexandra G. Evstafieva   +3 more
openaire   +2 more sources

Oxygen-dependent regulation of the activating transcription factor-4 (ATF-4)

Die Prolyl-4-Hydroxylase-Domäne-Enzyme 1-3 (PHD1-3) sind maßgeblich an der Regulation der Proteinstabilität der alpha-Untereinheit des Hypoxie-induzierbaren Faktors (HIF) beteiligt, welcher als wichtigster Transkriptionsfaktor der Sauerstoff-abhängigen Genexpression angesehen wird. Des Weiteren sind die PHDs auch an der Regulation Sauerstoff-abhängiger,
Wottawa, Marieke Claudia, Braus, Gerhard, Georg-August-Universität Göttingen, Melchior, Frauke   +3 more
openaire   +1 more source