Activating Transcription Factor 4 (ATF4) Regulates Neuronal Activity by Controlling GABABR Trafficking. [PDF]
J Neurosci, 2018 Activating Transcription Factor 4 (ATF4) has been postulated as a key regulator of learning and memory. We previously reported that specific hippocampal ATF4 downregulation causes deficits in synaptic plasticity and memory and reduction of glutamatergic functionality. Here we extend our studies to address ATF4's role in neuronal excitability.
Corona C +5 more
europepmc +4 more sources
Activating transcription factor 4-dependent lactate dehydrogenase activation as a protective response to amyloid beta toxicity. [PDF]
Brain Commun, 2021 Niccoli T +10 more
europepmc +3 more sources
Gut Microbiota-Related Evidence Provides New Insights Into the Association Between Activating Transcription Factor 4 and Development of Salt-Induced Hypertension in Mice [PDF]
Frontiers in Cell and Developmental Biology, 2020 Activating transcription factor 4 (ATF4), which regulates genes associated with endoplasmic reticulum stress, apoptosis, autophagy, the gut microbiome, and metabolism, has been implicated in many diseases.
Tian-hao Liu +11 more
doaj +2 more sources
The transcription factor Zfp281 sustains CD4+ T lymphocyte activation through directly repressing Ctla-4 transcription [PDF]
Cellular & Molecular Immunology, 2019 Abstract The expression of coinhibitory receptors, such as CTLA-4, on effector T cells is a key mechanism for the negative regulation of T-cell activation. However, the transcriptional regulation of CTLA-4 is not well understood. Zfp281, a C2H2 zinc finger protein, is a negative regulator of pluripotency maintenance of embryonic stem cells ...
Jing Guo +11 more
openalex +3 more sources
Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4. [PDF]
Cell Cycle, 2016 We found that inhibitors of mitochondrial respiratory chain complexes III (myxothiazol) and I (piericidin A) in some epithelial carcinoma cell lines induce transcription of the p53-responsive SESN2 gene that plays an important role in stress response and homeostatic regulation. However, the effect did not depend on p53 because i) there was no induction
Garaeva AA +3 more
europepmc +4 more sources
Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4. [PDF]
J Biol Chem, 2017 Previous studies have shown that glucagon cooperatively interacts with insulin to stimulate hepatic FGF21 gene expression. Here we investigated the mechanism by which glucagon and insulin increased FGF21 gene transcription in primary hepatocyte cultures.
Alonge KM, Meares GP, Hillgartner FB.
europepmc +4 more sources
Activating transcription factor 4 promotes angiogenesis of breast cancer through enhanced macrophage recruitment. [PDF]
Biomed Res Int, 2015 Angiogenesis plays an important role in the progression of tumor. Besides being regulated by tumor cells per se, tumor angiogenesis is also influenced by stromal cells in tumor microenvironment (TME), for example, tumor associated macrophages (TAMs).
Liu C +11 more
europepmc +4 more sources
Insulin inhibits melanoma tumor growth through the expression of activating transcription factor 4, without detectable expression of transcription factor CHOP: an in vivo model [PDF]
Anais Brasileiros de DermatologiaDaniel do Prado +4 more
doaj +2 more sources
Involvement of mitochondrial unfolded protein response and activating transcription factor 4 in the mitochondrial damage pathway of BEAS-2B cells induced by cigarette smoke extracts. [PDF]
J Thorac DisJin J +9 more
europepmc +2 more sources
Understanding of the functional role(s) of the Activating Transcription Factor 4(ATF4) in HIV regulation and production. [PDF]
BMB Rep, 2018 Lee SD +5 more
europepmc +2 more sources