Results 31 to 40 of about 693,055 (312)

Role of activated transcription factor 4 (ATF4) in learning and memory

, 2011
The aim of this study is to understand the role of Activated Transcription Factor 4 (ATF4) in the processes of learning and memory. The topic of learning and memory has always aroused great interest from time immemorial and although a lot of researches have been focused on this subject for a long time, many mechanisms have not yet been fully understood.
Silvia Pasini
openalex   +3 more sources

Activating transcription factor 4 regulates osteoclast differentiation in mice [PDF]

Journal of Clinical Investigation, 2010
Activating transcription factor 4 (ATF4) is a critical transcription factor for osteoblast (OBL) function and bone formation; however, a direct role in osteoclasts (OCLs) has not been established. Here, we targeted expression of ATF4 to the OCL lineage using the Trap promoter or through deletion of Atf4 in mice.
Huiling, Cao, Shibing, Yu, Zhi, Yao, Deborah L, Galson, Yu, Jiang, Xiaoyan, Zhang, Jie, Fan, Binfeng, Lu, Youfei, Guan, Min, Luo, Yumei, Lai, Yibei, Zhu, Noriyoshi, Kurihara, Kenneth, Patrene, G David, Roodman, Guozhi, Xiao   +15 more
openaire   +2 more sources

The Role of Activating Transcription Factor 4 (ATF4) in the Physiological Response to Dietary Sulfur Amino Acid Restriction (OR27-01-19) [PDF]

Curr Dev Nutr, 2019
Jonsson W, Margolies N, Mirek E, Gettys T, Anthony T.   +4 more
europepmc   +3 more sources

High ATF4 Expression Is Associated With Poor Prognosis, Amino Acid Metabolism, and Autophagy in Gastric Cancer

Frontiers in Oncology, 2021
BackgroundThe role of activating transcription factor 4 (ATF4) underlying gastric cancer (GC) remains unclear. The purpose of this study was to investigate the expression levels and biological functions of ATF4 in GC.MethodsExpression of ATF4 was ...
Mingliang Wang, Yida Lu, Huizhen Wang, Youliang Wu, Xin Xu, Yongxiang Li   +5 more
doaj   +1 more source

SAT-183 Activating Transcription Factor 4 (ATF4) As A Possible Mediator Of Gluconeogenic And Lipogenic Actions Of Fat Mass And Obesity Associated (FTO) In Liver

J Endocr Soc, 2019
Mizuno T, Lew P.
europepmc   +2 more sources

Activating Transcription Factor 4 Is Translationally Regulated by Hypoxic Stress [PDF]

Molecular and Cellular Biology, 2004
Hypoxic stress results in a rapid and sustained inhibition of protein synthesis that is at least partially mediated by eukaryotic initiation factor 2alpha (eIF2alpha) phosphorylation by the endoplasmic reticulum (ER) kinase PERK. Here we show through microarray analysis of polysome-bound RNA in aerobic and hypoxic HeLa cells that a subset of ...
Jaime D, Blais, Vasilisa, Filipenko, Meixia, Bi, Heather P, Harding, David, Ron, Costas, Koumenis, Bradly G, Wouters, John C, Bell   +7 more
openaire   +2 more sources

MicroRNA-214 Suppresses Gluconeogenesis by Targeting Activating Transcriptional Factor 4 [PDF]

Journal of Biological Chemistry, 2015
Although the gluconeogenesis pathway is already a target for the treatment of type 2 diabetes, the potential role of microRNAs (miRNAs) in gluconeogenesis remains unclear. Here, we investigated the physiological functions of miR-214 in gluconeogenesis.
Kai, Li, Jin, Zhang, Junjie, Yu, Bin, Liu, Yajie, Guo, Jiali, Deng, Shanghai, Chen, Chunxia, Wang, Feifan, Guo   +8 more
openaire   +2 more sources

Time-resolved single-cell transcriptomics reveals the landscape and dynamics of hepatic cells in sepsis-induced acute liver dysfunction

JHEP Reports, 2023
Background & Aims: Sepsis-induced acute liver dysfunction often occurs early in sepsis and can exacerbate the pathology by triggering multiple organ dysfunction and increasing lethality.
Gan Chen, Chao Ren, Yao Xiao, Yujing Wang, Renqi Yao, Quan Wang, Guoxing You, Mingzi Lu, Shaoduo Yan, Xiaoyong Zhang, Jun Zhang, Yongming Yao, Hong Zhou   +12 more
doaj   +1 more source

Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma [PDF]

Cancer Biology & Therapy, 2012
It has been reported that activating transcription factor 4 (ATF4) increases the processes of tumor growth, metastasis and drug resistance. However, the role played by ATF4 in chemoresistance of hepatocellular carcinoma (HCC) remains unknown. Clarification of this role of ATF4 in HCC could greatly benefit the efficacy of clinical treatment of HCC.
Zhuhong, Zhang, Jing, Yin, Chunyan, Zhang, Ning, Liang, Nan, Bai, Antao, Chang, Yanhua, Liu, Zongjin, Li, Xiaoyue, Tan, Na, Li, Dan, Lv, Rong, Xiang, Yaping, Tian, Chenghu, Liu   +13 more
openaire   +2 more sources

Activating transcription factor 4

The International Journal of Biochemistry & Cell Biology, 2008
Activating transcription factor 4 (ATF4) belongs to the ATF/CREB (activating transcription factor/cyclic AMP response element binding protein) family of basic region-leucine zipper (bZip) transcription factors, which have the consensus binding site cAMP responsive element (CRE). ATF4 has numerous dimerization partners. ATF4 is induced by stress signals
Ameri, K, Harris, A
openaire   +3 more sources