Results 121 to 130 of about 16,783,083 (225)

The dual role of activating transcription factor 4: from cellular stress sentinel to cardiovascular disease intervention [PDF]

PeerJ
As the master orchestrator of integrated stress response, activating transcription factor 4 (ATF4) operates as a central molecular switch that directs cellular fate toward survival or death by regulating genes associated with oxidative stress ...
Yaping Wang, Jie Yuan, Feifan Wang, Hong Ma   +3 more
doaj   +2 more sources

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Phylogenetic analysis of the ATF4 proteins.

, 2013
Phylogenetic tree of the ATF4 proteins from invertebrates and vertebrates. The tree was constructed via a neighbor-joining algorithm using the Mega 4.0 program based on the multiple sequence alignment by ClusterX v1.83.
Ze-Zhi Zhang (406677), Xiao-Yun Li (406674), Shao-Ping Weng (148356), Hai-Tao Yue (406676), Jian-Guo He (148364), Li-Ran Pang (406675), Yong-Gui Chen (117670), Yi-Hong Chen (117661)   +7 more
core   +1 more source

The ATF4-glutamine axis: a central node in cancer metabolism, stress adaptation, and therapeutic targeting

Cell Death Discovery
At the center of tumor(neoplasm) metabolic adaptation lies activating transcription factor 4 (ATF4), a key regulator that orchestrates Glutamine (Gln) uptake, utilization, and redox balance under conditions of nutrient deprivation and oxidative stress ...
Xing Yan, Changhong Liu
doaj   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Hyperhomocysteinemia and Vitamin B Deficiency as Potential Aggravating Factors in Huntington's Disease: A Prospective Monocentric Study

Movement Disorders, EarlyView.
Abstract Background Although not confirmed, some studies have suggested that elevated homocysteine levels are common in patients with Huntington's disease (HD). Its clinical relevance remains unclear. Objectives We aimed to assess vitamin B and homocysteine levels in HD patients and explore the relationships among hyperhomocysteinemia, vitamin B ...
Salomé Puisieux, Elise Pourié, Céline Bonnet, Lucie Hopes, Solène Frismand, Myriam Bronner, Virginie Roth, Marion Wandzel, Natacha Sloboda, Laetitia Lambert, Abderrahim Oussalah, Amélia Julien, Irina Rotaru, Rosa‐Maria Guéant‐Rodriguez, Jean Louis Guéant, Carine Bossenmeyer‐Pourié, Mathilde Renaud   +16 more
wiley   +1 more source

Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase

, 2017
The anti-leukemic agent asparaginase activates the integrated stress response (ISR) kinase GCN2 and inhibits signaling via mechanistic target of rapamycin complex 1 (mTORC1).
Ronald C. Wek, Park, Jinhee, Inna A. Nikonorova, Anthony, Tracy G., Al-Baghdadi, Rana J. T., Mirek, Emily T., Wang, Yongping, Jinhee Park, Tracy G. Anthony, Yongping Wang, Emily T. Mirek, William J. Belden, Rana J. T. Al-Baghdadi, Belden, William J., Nikonorova, Inna A., Wek, Ronald C.   +15 more
core   +1 more source

Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals

Integrative Zoology, EarlyView.
This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong, Chunxu Wang, Enqing Pei, Liang Zhao, Simin Chai, Ran Tian   +5 more
wiley   +1 more source

Role of activated transcription factor 4 (ATF4) in learning and memory

, 2011
The aim of this study is to understand the role of Activated Transcription Factor 4 (ATF4) in the processes of learning and memory. The topic of learning and memory has always aroused great interest from time immemorial and although a lot of researches have been focused on this subject for a long time, many mechanisms have not yet been fully understood.
openaire   +1 more source

ATF4 expression in thermogenic adipocytes is required for cold-induced thermogenesis in mice via FGF21-independent mechanisms

Scientific Reports
In brown adipose tissue (BAT), short-term cold exposure induces the activating transcription factor 4 (ATF4), and its downstream target fibroblast growth factor 21 (FGF21).
Sarah H. Bjorkman, Alex Marti, Jayashree Jena, Luis Miguel García-Peña, Eric T. Weatherford, Kevin Kato, Jivan Koneru, Jason Chen, Ayushi Sood, Matthew J. Potthoff, Christopher M. Adams, E. Dale Abel, Renata O. Pereira   +12 more
doaj   +1 more source