Results 131 to 140 of about 16,512,730 (230)

YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2‐m5C Modified ATF4 mRNA

Cancer Science, EarlyView.
The diagram depicts the core axis and the key finding: “Targeting YBX1/NSUN2 abrogates HNSCC progression”. Within left‐sided HNSCC cells, NSUN2 mediates m5C methylation on the CDS of ATF4 mRNA; YBX1 then specifically recognizes and binds this modified site, augmenting ATF4 mRNA stability, which ultimately promotes cancer cell proliferation, migration ...
Yanwei Li, Shuang Li, Yang Li, Zhanyu Pan   +3 more
wiley   +1 more source

Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner

Cell Reports
Summary: Loss of muscle mass is a feature of chronic illness and aging. Here, we report that skeletal muscle-specific thrombospondin-1 transgenic mice (Thbs1 Tg) have profound muscle atrophy with age-dependent decreases in exercise capacity and premature
Davy Vanhoutte, Tobias G. Schips, Rachel A. Minerath, Jiuzhou Huo, Naga Swathi Sree Kavuri, Vikram Prasad, Suh-Chin Lin, Michael J. Bround, Michelle A. Sargent, Christopher M. Adams, Jeffery D. Molkentin   +10 more
doaj   +1 more source

The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP

, 2007
When an essential amino acid is limited, a signaling cascade is triggered that leads to increased translation of the 'master regulator', activating transcription factor 4 (ATF4), and resulting in the induction of specific target genes. Binding of ATF4 to
Parry, Laurent, Carraro, Valerie, Fafournoux, Pierre, Maurin, Anne-Catherine, Chambon, Christophe, C., Chaveroux, Cedric, Chérasse, Yoan, Jousse, Celine, Deval, Christiane, Bruhat, Alain, Chambon, Christophe, Chambon, Christophe,   +11 more
core   +1 more source

Autophagy Regulates Foxo1 Protein Abundance to Control Hepatic Glucose Production in Glucagon Signalling

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim During fasting, the liver undergoes coordinated metabolic adaptations to maintain systemic energy homeostasis. These adaptations are driven in part by glucagon, which promotes hepatic glucose production (HGP) and fatty acid oxidation (FAO) through mechanisms involving the transcription factor Foxo1.
Zheng Shen, Wanbao Yang, Quan Pan, Wen Jiang, Jeffrey Guo, Yuxiang Sun, Nicolaas Deutz, Bhimanagouda S. Patil, Pingwei Li, Shaodong Guo   +9 more
wiley   +1 more source

Heregulin induces expression, DNA binding activity and transactivating functions of basic leucine zipper activating transcription factor 4

, 2000
Heregulin β1 (HRG), a combinatorial ligand for human epidermal growth factor receptor 3 and human epidermal growth factor receptor 4 receptors, is a regulatory secretory polypeptide with distinct biological effects such as growth stimulation ...
Kumar, Rakesh, Talukder, Amjad H., Vadlamudi, Ratna, Mandal, Mahitosh   +3 more
core   +1 more source

A comparative analysis of cell death signalling in RNA and DNA virus infections and potential inhibitory strategies

The FEBS Journal, EarlyView.
RNA and DNA viruses can manipulate host cell death through various mechanisms. RNA viruses (H1N1, SARS‐CoV‐2) induce acute apoptosis, necroptosis, and pyroptosis to promote rapid viral transmission and epithelial barrier damage. In contrast, DNA viruses (HSV‐1, EBV) regulate these mechanisms to sustain a lytic‐latency cycle, evade immune response and ...
Panagiotis Keramidas, Maria Pitou, Amalia Aggeli, Sotiris Varlamis, Theodora Choli‐Papadopoulou   +4 more
wiley   +1 more source

Correction to “Combined inhibition of de novo pyrimidine synthesis and ATR promotes ATF4‐mediated cell death in TP53‐deficient ALL” [PDF]

Hemasphere
HemaSphere, Volume 10, Issue 10, October 2026.
europepmc   +2 more sources

Proteostasis in the regulation of pancreatic islet cell plasticity

Journal of Diabetes Investigation, EarlyView.
Adaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Jun Shirakawa
wiley   +1 more source

Targeting NAT10 inhibits osteosarcoma progression via ATF4/ASNS-mediated asparagine biosynthesis

Cell Reports Medicine
Summary: Despite advances in treatment, the prognosis of patients with osteosarcoma remains unsatisfactory, and searching for potential targets is imperative.
Yutong Zou, Siyao Guo, Lili Wen, Dongming Lv, Jian Tu, Yan Liao, Weidong Chen, Ziyun Chen, Hongbo Li, Junkai Chen, Jingnan Shen, Xianbiao Xie   +11 more
doaj   +1 more source

One day of environment‐induced heat stress causes injury to the murine kidney

Experimental Physiology, EarlyView.
Abstract Environment‐induced heat stress (EIHS) results from sustained body temperature elevation owing to prolonged exposure to heat and humidity. We hypothesized that EIHS would cause kidney injury and cellular dysfunction. To test this hypothesis, female C57 mice were exposed to EIHS (n = 14; 37.6°C, 42.0% relative humidity) or thermoneutral (TN ...
Melissa Roths, Alyona Michael, Zachary J. Schlader, Joshua T. Selsby   +3 more
wiley   +1 more source