Results 151 to 160 of about 16,512,730 (230)

The Cancer Cell Metabolic Reprogramming Remodels the Tumor Microenvironment: Molecular Mechanisms and Therapeutic Strategies

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review elucidates how cancer cell metabolic reprogramming—across glucose, lipid, amino acid, and nucleotide pathways—remodels the tumor microenvironment to suppress anti‐tumor immunity and promote immune escape. Targeting these metabolic axes offers promising strategies to overcome immunotherapy resistance and enhance cancer treatment.
Guoqing Xiang, Zhicheng Zhou, Xue Jiang, Zhenguang Du, Yangyang Zhan, Xinli Liu   +5 more
wiley   +1 more source

Reactive Oxygen Species as Central Coordinators of Organelle Stress and Tumor Radiosensitivity

Cell Biochemistry and Function, Volume 44, Issue 10, October 2026.
ABSTRACT Radiotherapy is a major modality for cancer treatment, but therapeutic responses vary substantially across tumor types and patients. Beyond direct DNA damage, radiation‐induced reactive oxygen species (ROS) are increasingly recognized as dynamic regulators of cellular stress responses.
Guangyu Ju, Zimeng Wang, Jingjing Xiao, Qinxue Wu, Zhiying Yang, Yuqing Miao, Shuanghu Yuan, Junchao Qian   +7 more
wiley   +1 more source

Visual system function requires translational regulation of ATF4 by Hbs1-Pelo

EMBO Reports
Deletion mutations in the translation termination factor HBS1L result in progressive loss of vision in human patients, amongst other developmental anomalies. The etiology of vision defects seen with HBS1L deletion remains unknown.
Katherine Tempro, Inês Lago-Baldaia, Narayanan Nampoothiri V P, Christopher Garbark, Abby J Carney, Vilaiwan M Fernandes, Deepika Vasudevan   +6 more
doaj   +1 more source

Modulation of Endoplasmic Reticulum Stress via CEBPB: A Potential Molecular Link to Therapeutic Action in Substance Use Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
We identified endoplasmic reticulum (ER) stress modulation as a convergent transcription signature across fentanyl and multiple substance use disorder (SUD)‐relevant treatments. Key ER stress genes, including TRIB3, XBP1, and DDIT3, were downregulated, while CEBPB emerged as a shared upstream regulator linked to ER stress–related proteins.
Cheng Zhang, Hu Li, Ming‐Fen Ho
wiley   +1 more source

Sex‐Specific Effects of Dexmedetomidine on Brain Microvascular Endothelial Cell Function After Traumatic Brain Injury in Juvenile Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Traumatic brain injury (TBI) induces acute, sex‐specific activation of endoplasmic reticulum (ER) stress, inflammatory signaling, and ferroptotic mechanisms within brain microvascular endothelial cells (BMECs). Administration of dexmedetomidine (DEX) produces both sex‐dependent and sex‐independent modulatory effects on BMECs, prominently suppressing ...
Yara Mashal, Jie Fan, Tia Atoui, Zahrah Naseer, Sara Moughni, Iman Tawil, Zhi Zhang   +6 more
wiley   +1 more source

Recalibrating the apoptotic threshold: Ubiquitin‐regulated ER stress signalling in colorectal cancer

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Ubiquitin‐dependent turnover of ER‐stress sensors, proteostasis factors, and apoptotic regulators can recalibrate the apoptotic threshold in colorectal cancer, balancing adaptive survival against terminal cell death. Defining these context‐dependent vulnerabilities may enable strategies that overcome stress adaptation and restore apoptotic competence ...
Jing Hu, Shanliang Zheng, Ying Hu
wiley   +1 more source

Harnessing Terminalia arjuna in Next Generation Phytomedicine: Cutting Edge Nutraceutical Trends Shaping Food and Health

Food Science &Nutrition, Volume 14, Issue 10, October 2026.
This graphical abstract illustrates the complete translational pipeline of Terminalia arjuna in modern phytomedicine and functional food development. It is rich in key bioactive compounds like arjunolic acid, arjungenin, flavonoids, and tannins which serve as the foundation for the plant's versatile medicinal uses and offers broad therapeutic benefits ...
Ishani Banerjee, Fahika Nazeerulla, Manash Kumar Paul, Sujit Kumar Bhutia, Deblina Basu, Subhadip Mukhopadhyay   +5 more
wiley   +1 more source

Role of Triceps Muscle Fiber‐Specific Myokines in Pancreatic β‐Cell Protection: Implications for Type 2 Diabetes: A Narrative Review

Health Science Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background and Aims Type 2 diabetes (T2D) is a major global health challenge, primarily driven by insulin resistance and progressive β‐cell dysfunction aggravated by chronic low‐grade inflammation. Skeletal muscle has emerged as a pivotal endocrine organ through the secretion of myokines, which exert systemic metabolic and immunomodulatory ...
Christian Tague, Dujardin Makeda, Hermann Yokolo, Joshua Ekouo   +3 more
wiley   +1 more source

Trophoblast Extracellular Vesicles Rewire Immunity: A Symptom‐Relief Avenue for Recessive Dystrophic Epidermolysis Bullosa

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
First‐trimester trophoblast EVs are enriched in anti‐inflammatory proteins, lipids, and immunoregulatory miRNAs. EVT‐EVs reprogram monocytes toward a pro‐resolving phenotype and restore immune homeostasis in RDEB, supporting their potential as offering a scalable off‐the‐shelf therapy for chronic inflammatory diseases.
Nell Hirt, Enzo Manchon, Ming Wu, Helene Le Buanec, Pauline Bataille, Emmanuelle Bourrat, Jean‐David Bouaziz, Nabila Jabrane‐Ferrat, Reem Al‐Daccak   +8 more
wiley   +1 more source

Single‐Cell Analysis of Cartilage‐Derived Cells Identifies Diverse Populations and a Cholesterol/ER‐Stress Chondrocyte Subset in Knee OA

Journal of Orthopaedic Research, Volume 44, Issue 10, October 2026.
ABSTRACT This study aimed to elucidate the cellular and molecular mechanisms underlying knee osteoarthritis pathogenesis by analyzing chondrocyte populations and their spatial distribution using single‐cell RNA sequencing (scRNA‐seq). Knee cartilage cells underwent scRNA‐seq.
Yu Kobori, Kohei Nishitani, Hiroyuki Yoshitomi, Akinori Murakami, Kazuki Ichiyanagi, Shigeo Yoshida, Jiu Tanaka, Shinichi Kuriyama, Shinichiro Nakamura, Akio Sakamoto, Takashi Noguchi, Yugo Morita, Takashi Sono, Takayuki Fujii, Koichi Murata, Junya Toguchida, Hideki Ueno, Yasuhiro Murakawa, Chikashi Terao, Shuichi Matsuda   +19 more
wiley   +1 more source