Results 161 to 170 of about 16,783,083 (225)

Mitochondrial DNA in Tumor Evolution and Heterogeneity: Characteristics, Technological Advances, Applications and Challenges

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review highlights mitochondrial DNA (mtDNA) somatic mutations as an emerging and potent endogenous lineage marker, offering distinct advantages over traditional nuclear genomic (nDNA) approaches. Lineage tracing based on mtDNA mutations has matured into an indispensable tool, providing unprecedented insights into tumor biology and holding ...
Zifeng Ruan, Zihao Chen, Weicheng Yu, Maolei Zhang, Xingguo Liu   +4 more
wiley   +1 more source

ATF4 Signaling in HIV-1 Infection: Viral Subversion of a Stress Response Transcription Factor

Cellular integrated stress response (ISR), the mitochondrial unfolded protein response (UPRmt), and IFN signaling are associated with viral infections.
Corne, Adrien, Florine Adolphe, Jérôme Estaquier, Adolphe, Florine, Corsi, Jean-Marc, Sébastien Gaumer, Jean-Marc Corsi, Adrien Corne, Estaquier, Jérôme, Gaumer, Sébastien   +9 more
core   +1 more source

Creb3l1 Overexpression Improves Flexor Tendon Repair in Aged Rats

Aging Cell, Volume 25, Issue 9, September 2026.
Aging impairs flexor tendon repair, with aged tendons showing reduced Col1a1 and Sparc expression and compromised mechanical properties. The transcription factor Creb3l1 binds both gene promoters and drives their expression; its overexpression restores Col1a1 and Sparc levels and improves the gliding function, healing strength, and elastic modulus of ...
Qian Qian Yang, Zhanghao Huang, Yan Xue, Jia Yu Shi, You Lang Zhou   +4 more
wiley   +1 more source

CKAP4 Regulates ERS‐Induced Apoptosis in Osteoclasts Through FOXO3 in Periodontitis

Cell Proliferation, Volume 59, Issue 9, September 2026.
CKAP4 promotes the transcription of PERK via FOXO3 in OCs, thereby facilitating ER stress‐induced apoptosis. In periodontitis, the reduction of CKAP4 in OCs leads to decreased OC apoptosis, which exacerbates alveolar bone resorption. ABSTRACT Periodontitis is a prevalent oral disease characterised by chronic inflammation and irreversible alveolar bone ...
Jiayu Cheng, Dihao Tao, Wenzhe Wang, Huiyu Wang, Hanzhe Wang, Yufan Liang, Jia Guo, Wenhao Liu, Yiming Wang, Jianhua Yang, Xiaoning He, Ce Shan, Bei Li   +12 more
wiley   +1 more source

Dissection of Mitochondrial Function via Chemical Perturbation and Single‐Cell Profiling

Cell Proliferation, Volume 59, Issue 9, September 2026.
We establish a systematic framework to dissect mitochondrial function at the module level by combining targeted chemical perturbations with scRNA‐seq. This approach reveals shared and module‐specific programs linking mitochondrial activity to mito‐nuclear communication, stress response, and cell cycle, highlighting the tight coupling between ...
Hao Luo, Xiaona Yin, Hongxin He, Yaning Wang, Hongbo Zhang   +4 more
wiley   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, Volume 59, Issue 9, September 2026.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Ferroptosis‐Based Peripheral Immune Dysregulation and Diagnostic Signatures in Parkinson's Disease: An RNA Transcriptomic and Single‐Cell Immune Sequencing Analysis

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
This study explored the crosstalk between ferroptosis‐related genes and peripheral immune alterations in Parkinson's disease. We constructed a gene signature and classified molecular subtypes, and further pinpointed key ferroptosis‐associated molecules in immune cells and neuronal cells.
Lei Cheng, Jing Zhang, Wen‐Ting Shi, Qing Ye, Chen Huang, Zhong‐Yan Zhou   +5 more
wiley   +1 more source

Activating transcription factor 3 modulates protein kinase C epsilon activation in diabetic peripheral neuropathy

, 2019
Ying-Shuang Chang,1 Hung-Wei Kan,2 Yu-Lin Hsieh1,3 1Department of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; 2Department of Anatomy and Cell Biology, College of Medicine, National Taiwan ...
Kan HW, Chang YS, Hsieh YL
core  

ATF4/SCO2 Inhibits Ferroptosis in Lung Cancer Through Activating the MAPK Signaling Pathway. [PDF]

J Biochem Mol Toxicol
Yu L, Zhang S, He J, Ma B, Song X, Qiu R, Yu B.   +6 more
europepmc   +1 more source

ATF4 orchestrates cancer hallmarks: Stress adaptation, metabolic reprogramming and immune suppression. [PDF]

iScience
Peng Z, Xu T, Xia Z, Han H, Ding B, Yang L, Ren W, Ye H.   +7 more
europepmc   +1 more source