Results 1 to 10 of about 634,551 (325)

Asperuloside inhibits the activation of pancreatic cancer-associated fibroblasts via activating transcription factor 6 [PDF]

Discover Oncology
Background Pancreatic cancer-associated fibroblasts (CAFs) play a crucial role in tumor progression and immune evasion. Asperuloside (ASP) is an iridoid glycoside with potential anti-tumor properties.
Ling-zhi Cao, Fan-hui Yang, Hao Zhang, Ai-min Jia, Su-ping Li, Hu-ling Wen   +5 more
doaj   +6 more sources

Levels of Hepatic Activating Transcription Factor 6 and Caspase-3 Are Downregulated in Mice after Excessive Training [PDF]

Frontiers in Endocrinology, 2017
Recently, we demonstrated that different running overtraining (OT) protocols with the same external load, but performed downhill (OTR/down), uphill (OTR/up), and without inclination (OTR), led to hepatic fat accumulation. As the disruption of endoplasmic
Ana P. Pinto, Alisson L. da Rocha, Luciana da C. Oliveira, Gustavo P. Morais, Larissa G. de Vicente, Dennys E. Cintra, José R. Pauli, Leandro P. Moura, Eduardo R. Ropelle, Adelino S. R. da Silva, Adelino S. R. da Silva   +10 more
doaj   +7 more sources

Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease. [PDF]

J Clin Invest, 2016
Deregulated protein and Ca2+ homeostasis underlie synaptic dysfunction and neurodegeneration in Huntington disease (HD); however, the factors that disrupt homeostasis are not fully understood.
Naranjo JR, Zhang H, Villar D, González P, Dopazo XM, Morón-Oset J, Higueras E, Oliveros JC, Arrabal MD, Prieto A, Cercós P, González T, De la Cruz A, Casado-Vela J, Rábano A, Valenzuela C, Gutierrez-Rodriguez M, Li JY, Mellström B.   +18 more
europepmc   +10 more sources

Activating Transcription Factor 6 Mediates Inflammation in Experimental Varicocele-Induced Epididymal Epithelial Cells [PDF]

Journal of Inflammation Research
Yin-shan Jin,* Yuan-qing Cui,* Yan-ping Xu,* Jie Chen, Xue-bao Zhang, Xiong Wang Department of Reproductive Medicine, Yantai Yuhuangding Hospital, Yantai, 264000, People’s Republic of China*These authors contributed equally to this ...
Jin YS, Cui YQ, Xu YP, Chen J, Zhang XB, Wang X   +5 more
doaj   +5 more sources

The role of activating transcription factor 6 in hydroxycamptothecin-induced fibroblast autophagy and apoptosis [PDF]

Journal of Orthopaedic Surgery and Research, 2021
Background The over-proliferation of fibroblasts is considered to be the main cause of scar adhesion after joint surgery. Hydroxycamptothecin (HCPT), though as a potent antineoplastic drug, shows preventive effects on scar adhesion.
Jin Tao, Hui Chen, Xiaolei Li, Jingcheng Wang   +3 more
doaj   +6 more sources

Arsenic Activates the ER Stress-Associated Unfolded Protein Response via the Activating Transcription Factor 6 in Human Bronchial Epithelial Cells [PDF]

Biomedicines, 2022
Arsenic is a well-known human carcinogen associated with a number of cancers, including lung cancers. We have previously shown that long-term exposure to an environmentally relevant concentration of inorganic arsenic (As3+) leads to the malignant ...
Priya Wadgaonkar, Zhuoyue Bi, Junmei Wan, Yao Fu, Qian Zhang, Bandar Almutairy, Wenxuan Zhang, Yiran Qiu, Chitra Thakur, Maik Hüttemann, Fei Chen   +10 more
doaj   +4 more sources

Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish. [PDF]

PLoS Genetics, 2014
Fatty liver disease (FLD) is characterized by lipid accumulation in hepatocytes and is accompanied by secretory pathway dysfunction, resulting in induction of the unfolded protein response (UPR).
Deanna L Howarth, Claudia Lindtner, Ana M Vacaru, Ravi Sachidanandam, Orkhontuya Tsedensodnom, Taisa Vasilkova, Christoph Buettner, Kirsten C Sadler   +7 more
doaj   +6 more sources

Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Ischemia/reperfusion injury impairs proteostasis, and triggers adaptive cellular responses, such as the unfolded protein response (UPR), which functions to restore endoplasmic reticulum homeostasis. After cardiac arrest (CA) and resuscitation,
Yuntian Shen, Ran Li, Shu Yu, Qiang Zhao, Zhuoran Wang, Huaxin Sheng, Wei Yang   +6 more
doaj   +6 more sources

Pharmacological Activating Transcription Factor 6 Activation Is Beneficial for Liver Retrieval With ex vivo Normothermic Mechanical Perfusion From Cardiac Dead Donor Rats [PDF]

Frontiers in Surgery, 2021
Background: Normothermic machine perfusion (NMP) could be beneficial for organ retrieval from donors after cardiac death (DCD). Activating transcription factor 6 (ATF6) was recently shown to mitigate liver ischemia/reperfusion injury and confer ...
Nuo Cheng, Ji-Hua Shi, Yang Jin, Yuan-Bin Shi, Xu-Dong Liu, Hua-Peng Zhang, Sheng-Li Cao, Han Yang, Wen-Zhi Guo, Shui-Jun Zhang   +9 more
doaj   +2 more sources

Inhibition of the Activating Transcription Factor 6 Branch of Endoplasmic Reticulum Stress Ameliorates Brain Injury after Deep Hypothermic Circulatory Arrest. [PDF]

J Clin Med, 2023
Zhang YP, Yang Q, Li YA, Yu MH, He GW, Zhu YX, Liu ZG, Liu XC.   +7 more
europepmc   +3 more sources