Results 161 to 170 of about 472,934 (298)

PD-L1 autoregulation promotes the proliferation, migration and invasion of glioblastoma cells via GP130/JAK2/STAT3/IRAK2/IL6 signaling pathway

Scientific Reports
Glioblastoma (GBM) cells mediate immunosuppressive microenvironment, leading to poor response to programmed death-ligand 1(PD-L1) inhibitor therapy. How PD-L1 in GBM cells confers to GBM immunosuppressive microenvironment remains unclear.
Xin Xie, Jingdi Bai, Yuhui Peng, Pingping Chen, Zhuxue Zhang, Daogui Fan, Feng Zhou, Yuan Yuan, Jiyun Liu, Yu Zhou, Qin Hong, Jianjun Hu, Juanjuan Duan, Wenli Fu, Ting Zhang, Hongmei Zeng, Jie Deng, Yangting Dong, Ying Liu, Xiaolan Qi, Wei Hong, Yan He, Chunlin Zhang, Wenfeng Yu, Qintian Yang, Wei Yi, Hua Bai, Qifang Zhang   +27 more
doaj   +1 more source

The zinc finger transcription factor Early Growth Response 2 (Egr-2) is an intrinsic regulator of T cell tolerance and homeostasis

, 2009
PhDTolerance of T cells to self-antigen is crucial to prevent the development of autoimmune disease. How self-tolerance is controlled at the transcriptional level is, however, unknown. We discovered that the transcription factor Early Growth Response 2
Symonds, Alistair
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress. [PDF]

Gastroenterology, 2020
Stengel ST, Fazio A, Lipinski S, Jahn MT, Aden K, Ito G, Wottawa F, Kuiper JWP, Coleman OI, Tran F, Bordoni D, Bernardes JP, Jentzsch M, Luzius A, Bierwirth S, Messner B, Henning A, Welz L, Kakavand N, Falk-Paulsen M, Imm S, Hinrichsen F, Zilbauer M, Schreiber S, Kaser A, Blumberg R, Haller D, Rosenstiel P.   +27 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Cloning and expression of the FtWRKY28 gene from Fagopyrum tataricum under low phosphorus and hormone treatment

Xibei zhiwu xuebao
[Objective] WRKY transcription factors are involved in response to low phosphorus stress in plants. Based on transcriptome data of Tartary buckwheat (Fagopyrum tataricum ) under low phosphorus stress, the aim of this study is to isolate FtWRKY28 gene ...
WEN Biyao, PENG Xixu, TIAN Jianhong, WU Qingtao, WANG Haihua, TANG Xinke   +5 more
doaj   +1 more source

Die Epithelzell-spezifische Aktivierung des „Activating Transcription Factor 6“ fördert die Dysbiose und die Tumorentstehung im Dickdarm.

, 2018
The activating transcription factor 6 (ATF6) is one of the major transducers of the endoplasmic reticulum unfolded protein response (ER UPR). To study how ATF6 signaling affects intestinal epithelial cells (IEC) and intestinal health, nATF6IEC mice were ...
Lobner, Elena
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

SRM1 phosphorylation coordinates plant immunity and growth in Arabidopsis

Cell Reports
Summary: Plants mount an array of immune responses to combat pathogen invasion, which is often accompanied by growth inhibition. How plants coordinate immunity and growth is of great agricultural significance. Here, we report an MYB-related transcription
Jing Liu, Chao Xu, Le Chang, Miqi Xu, Xuncheng Wang, Yueyao Wang, Chunqiu Liu, Xing Wang Deng, Guangming He   +8 more
doaj   +1 more source

Asynchronous Rhythm of Steroidogenic Factor 1 and Period Homolog 2 mRNA Expression in Mouse Y1 Adrenocorticol Tumor Cells

, 2010
The relationship between the expression of Steroidogenic factor 1 (Sf1) and the circadian-related gene, period homolog 2 (Per2), in the adrenal cortex is still unknown.
Toshihiko Yanase, Kouichirou Sonoda, Taijiro Okabe, Kenji Ohe, Ryoichi Takayanagi, Masatoshi Nomura, Koichi Node, Makoto Akashi, Koichi Oba, Hajime Nawata   +9 more
core