Results 31 to 40 of about 634,551 (325)

Activation of the inflammatory transcription factor nuclear factor interleukin-6 during inflammatory and psychological stress in the brain [PDF]

Journal of Neuroinflammation, 2013
Abstract Background The transcription factor nuclear factor interleukin 6 (NF-IL6) is known to be activated by various inflammatory stimuli in the brain. Interestingly, we recently detected NF-IL6-activation within the hypothalamus-pituitary-adrenal (HPA)-axis of rats after systemic lipopolysaccharide (LPS)-injection.
Fuchs, Franziska, Damm, Jelena, Gerstberger, Rudiger, Roth, Joachim, Rummel, Christoph, Justus Liebig University Giessen   +5 more
openaire   +5 more sources

ORMDL3 Functions as a Negative Regulator of Antigen-Mediated Mast Cell Activation via an ATF6-UPR-Autophagy–Dependent Pathway

Frontiers in Immunology, 2021
Antigen (Ag)-mediated mast cell activation plays a critical role in the immunopathology of IgE-dependent allergic diseases. Restraining the signaling cascade that regulates the release of mast cell-derived inflammatory mediators is an attractive ...
Jia Li, Md Ashik Ullah, Hongping Jin, Yuting Liang, Lihui Lin, Juan Wang, Xia Peng, Huanjin Liao, Yanning Li, Yiqin Ge, Li Li   +10 more
doaj   +1 more source

Ischemia and reperfusion injury in kidney transplantation : relevant mechanisms in injury and repair [PDF]

, 2020
Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation.
Berger, Stefan P., Leuvenink, Henri G. D., Nieuwenhuijs-Moeke, Gertrude J., Pischke, Soren E., Ploeg, Rutger J., Pol, Robert A., Sanders, Jan Stephan F., Struys, Michel   +7 more
core   +2 more sources

Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. [PDF]

Molecular and Cellular Biology, 1990
The promoter region of the interleukin-6 (IL-6) gene has a putative NF-kappa B-binding site. We found that a fragment of the IL-6 promoter containing the site specifically binds highly purified NF-kappa B protein and the NF-kappa B protein in nuclear extracts of phorbol ester-induced Jurkat cells.
Libermann, Towia A., Baltimore, David
openaire   +4 more sources

The Transcriptional Activator Hepatocyte Nuclear Factor 6 Regulates Liver Gene Expression [PDF]

Molecular and Cellular Biology, 1996
The hepatocyte nuclear factor 3(alpha) (HNF-3(alpha)), -3(beta), and -3(gamma) proteins share homology in the winged-helix/fork head DNA binding domain and mediate hepatocyte-enriched transcription of numerous genes whose expression is necessary for organ function. In this work, we identify a liver-enriched transcription factor, HNF-6, which recognizes
Robert H. Costa, Uzma Samadani
openaire   +3 more sources

Krüppel-like Factor 6 Suppresses the Progression of Pancreatic Cancer by Upregulating Activating Transcription Factor 3

Journal of Clinical Medicine, 2022
Background: As a member of the Krüppel-like factor (KLFs) family, Krüppel-like factor 6 (KLF6) plays a critical role in regulating key cellular functions. Presently, scholars have proved the important role of KLF6 in the tumorigenesis of certain cancers through a large number of experiments.
Qunli Xiong, Zhiwei Zhang, Yang Yang, Yongfeng Xu, Ying Zhou, Su Zhang, Jinlu Liu, Ying Zheng, Qing Zhu   +8 more
openaire   +2 more sources

Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response [PDF]

, 2017
Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR).
Bulleid, Neil J., Cain, Katharine, Chalmers, Fiona, Sweeney, Bernadette, van Lith, Marcel   +4 more
core   +2 more sources

Pre-pregnancy maternal obesity associates with endoplasmic reticulum stress in human umbilical vein endothelium [PDF]

, 2018
Obesity associates with the endoplasmic reticulum (ER) stress-induced endothelial dysfunction. Pregnant women with pre-pregnancy maternal obesity (PGMO) may transfer this potential risk to their offspring; however, whether ER stress occurs and associates
Farías, Marcelo, Pardo, Fabián, Silva, Luis, Sobrevia, Luis, Subiabre, Mario, Sáez, Pablo J., Toledo, Fernando, Villalobos-Labra, Roberto, Westermeier, Francisco   +8 more
core   +2 more sources

The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination

PLOS Biology, 2016
Growth factors of the gp130 family promote oligodendrocyte differentiation, and viability, and myelination, but their mechanisms of action are incompletely understood. Here, we show that these effects are coordinated, in part, by the transcriptional activator Krüppel-like factor-6 (Klf6).
David A. Braun, Sam Horng, Sam Horng, Elisabeth G. Kramer, Elisabeth G. Kramer, Cedric S. Raine, Jia Liu, Jia Liu, Setsu Sawai, Setsu Sawai, Benjamin M. Laitman, Benjamin M. Laitman, John N. Mariani, John N. Mariani, Patrizia Casaccia, Patrizia Casaccia, Q. Richard Lu, Xiomara Pedre, Xiomara Pedre, Natalie Burlant, Natalie Burlant, Youngmin A. Lee, German Nudelman, Jingya Zhang, Jingya Zhang, Linnea Asp, Linnea Asp, Scott L. Friedman, Candice Chapouly, Candice Chapouly, Hannah Loo, Hannah Loo, Gareth R. John, Gareth R. John, Goutham Narla, Nesanet Mitiku, Nesanet Mitiku, Yuko Hara, Elena Zaslavsky   +38 more
openaire   +5 more sources

African Swine Fever Virus K205R Induces ER Stress and Consequently Activates Autophagy and the NF-κB Signaling Pathway

Viruses, 2022
African swine fever virus (ASFV) is responsible for enormous economic losses in the global swine industry. The ASFV genome encodes approximate 160 proteins, most of whose functions remain largely unknown.
Qi Wang, Luyu Zhou, Jiang Wang, Dan Su, Dahua Li, Yongkun Du, Guoyu Yang, Gaiping Zhang, Beibei Chu   +8 more
doaj   +1 more source