Results 71 to 80 of about 338,751 (320)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Pathogenesis of respiratory failure in COVID-19 due to coagulopathy and endothelial dysfunction
Acta Biomedica ScientificaRespiratory failure is known to be the main clinical manifestation of COVID-19. However, the mechanism of its development has not been sufficiently studied.
T. O. Burdienko
doaj +1 more source
Anti-HK antibody inhibits the plasma contact system by blocking prekallikrein and factor XI activation in vivo [PDF]
, 2022 Zu‐Lin Chen +7 more
openalex +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A priori estimates of stationary solutions of an activator-inhibitor system [PDF]
Indiana University Mathematics Journal, 2007 We consider positive solutions of the stationary Gierer-Meinhardt system. Under suitable conditions on the exponents $p,q,r$ and $s$, different types of a priori estimates are obtained, existence and non-existence results of nontrivial solutions are derived, for both positive and zero source production cases.
Jiang, Huiqiang, Ni, Wei-Ming
openaire +2 more sources
Phase transition in thermodynamically consistent biochemical oscillators
, 2018 Biochemical oscillations are ubiquitous in living organisms. In an autonomous system, not influenced by an external signal, they can only occur out of equilibrium.
Barato, Andre C. +2 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
OncoImmunology, 2021 Emerging immunotherapies quest for better patient stratification in cancer treatment decisions. Moderate response rates of PD-1 inhibition in gastric and esophagogastric junction cancers urge for meaningful human model systems that allow for ...
Marlon Hußtegge +10 more
doaj +1 more source
, 2008 We present a bifurcation analysis of a normal form for travelling waves in one-dimensional excitable media. The normal form which has been recently proposed on phenomenological grounds is given in form of a differential delay equation.
Georg A. Gottwald +5 more
core +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source