Results 101 to 110 of about 50,825 (299)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Natural additives and agricultural wastes in biopolymer formulations for food packaging

Frontiers in Chemistry, 2014
The main directions in food packaging research are targeted towards improvements in food quality and food safety. For this purpose, food packaging providing longer product shelf-life, as well as the monitoring of safety and quality based upon ...
Arantzazu eValdés, Ana Cristina eMellinas, Marina eRamos, María Carmen eGarrigós, Alfonso eJiménez   +4 more
doaj   +1 more source

Polyphenols & Antioxidants Incorporation into Food packaging: Trends & Perspectives

, 2014
Natural antioxidants, including polyphenols, not related with possible toxicological side-effects as artificial molecules, are being used in active packaging in order to extend the shelf-life of foodstuffs and reduce the addition of antioxidants directly
Machado, A.V., Sanches-Silva, A., Costa, H.S., Albuquerque, T.G., on behalf of the Rose4Pack Project team, Ramos, F., Reis, A.R., Castilho, M.C., Carvalho-Costa, D.   +8 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Moisture migration as an influencing factor in food freshness biocomposite packaging: A trend analysis review

Next Materials
Global demand for fresh and high-quality food increased at this modern age to satisfy on quality requirement. Water moisture is majority affected the quality of a fresh food.
Mohamad Khairul Aiman Mohd Fauzi, Chigozie Charity Okwuwa, Nor Hanuni Ramli, Azren Aida Asmawi, Rajan Jose, Fatmawati Adam   +5 more
doaj   +1 more source

Biodegradable polymer nanocomposites for active food packaging [PDF]

E3S Web of Conferences
Biodegradable polymer nanocomposites have gained attention in recent years owing to their antimicrobial activity. The article summarizes recent developments in improving antimicrobial, mechanical and barrier properties of biodegradable polymers chitosan,
Roy Soumili, Singh Kulwinder, Kumar Abhishek   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Research Progress on the Application and Migration Characteristics of Plant Essential Oils in Antibacterial Active Packaging：A Review

Shipin gongye ke-ji
Plant essential oils are volatile, lipophilic compounds extracted from aromatic plants, most of which possess potent antibacterial properties, and some also have antioxidant effects.
Jiaxin LI, Qiancheng ZHAO, Guanliang SONG, Xinrui SU, Shengcong LIU, Yongsheng MA   +5 more
doaj   +1 more source