Active transport, cell nucleus - Open Access .click

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Efficient active transport of gene nanocarriers to the cell nucleus [PDF]

Proceedings of the National Academy of Sciences, 2003
The intracellular transport of therapeutic gene carriers is poorly understood, limiting the rational design of efficient new vectors. We used live-cell real-time multiple particle tracking to quantify the intracellular transport of hundreds of individual nonviral DNA nanocarriers with 5-nm and 33-ms resolution.
Junghae Suh, Denis Wirtz, Justin Hanes
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T3 Enters Axon Terminals of Mouse Cortical Neurons, Is Retrogradely Transported to the Cell Nucleus and Activates Gene Expression [PDF]

Journal of the Endocrine Society, 2021
Abstract Thyroid hormone (TH) is critical for brain development and function. T3 enters neurons through membrane transporters and reaches the cell nucleus where it binds to receptors (TR) to regulate gene transcription. However, neurons also express the type 3 deiodinase (D3), which is located in the cellular and nuclear membranes and ...
Csaba Fekete +5 more
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Endogenous interleukin 1 alpha must be transported to the nucleus to exert its activity in human endothelial cells. [PDF]

Molecular and Cellular Biology, 1994
We have previously shown that the signal peptideless cytokine interleukin 1 alpha (IL-1 alpha) may play a role as an intracellular regulator of human endothelial cell senescence (J. A. M. Maier, P. Voulalas, D. Roeder, and T. Maciag, Science 249:1570-1574, 1990). To investigate the potential intracellular function of IL-1 alpha, transformed endothelial
J. A. Maier, M. Statuto, G. Ragnotti
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Cytoplasmic retention of dengue virus capsid protein by metformin impairing nuclear transport. [PDF]