Results 1 to 10 of about 331,002 (265)

T3 Enters Axon Terminals of Mouse Cortical Neurons, Is Retrogradely Transported to the Cell Nucleus and Activates Gene Expression [PDF]

Journal of the Endocrine Society, 2021
Abstract Thyroid hormone (TH) is critical for brain development and function. T3 enters neurons through membrane transporters and reaches the cell nucleus where it binds to receptors (TR) to regulate gene transcription. However, neurons also express the type 3 deiodinase (D3), which is located in the cellular and nuclear membranes and ...
Salas-Lucia, Federico, Bocco, Barbara M L C, Rada, Kristof, Fekete, Csaba, Gereben, Balazs, Bianco, Antonio C   +5 more
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Cationic Polymer Brush-Modified Carbon Nanotube-Meditated eRNA LINC02569 Silencing Attenuates Nucleus Pulposus Degeneration by Blocking NF-κB Signaling Pathway and Alleviate Cell Senescence

Frontiers in Cell and Developmental Biology, 2022
Enhancer RNAs (eRNAs) are noncoding RNAs that synthesized at active enhancers. eRNAs have important regulatory characteristics and appear to be significant for maintenance of cell identity and information processing.
Yulin Huang, Jiaming Yang, Xizhe Liu, Xiaoshuai Wang, Kai Zhu, Zemin Ling, Baozhu Zeng, Ningning Chen, Shaoyu Liu, Fuxin Wei   +9 more
doaj   +1 more source

The correlation between cell and nucleus size is explained by an eukaryotic cell growth model.

PLoS Computational Biology, 2022
In eukaryotes, the cell volume is observed to be strongly correlated with the nuclear volume. The slope of this correlation depends on the cell type, growth condition, and the physical environment of the cell.
Yufei Wu, Adrian F Pegoraro, David A Weitz, Paul Janmey, Sean X Sun   +4 more
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Efficient active transport of gene nanocarriers to the cell nucleus [PDF]

Proceedings of the National Academy of Sciences, 2003
The intracellular transport of therapeutic gene carriers is poorly understood, limiting the rational design of efficient new vectors. We used live-cell real-time multiple particle tracking to quantify the intracellular transport of hundreds of individual nonviral DNA nanocarriers with 5-nm and 33-ms resolution.
Junghae, Suh, Denis, Wirtz, Justin, Hanes   +2 more
openaire   +2 more sources

Endogenous interleukin 1 alpha must be transported to the nucleus to exert its activity in human endothelial cells. [PDF]

Molecular and Cellular Biology, 1994
We have previously shown that the signal peptideless cytokine interleukin 1 alpha (IL-1 alpha) may play a role as an intracellular regulator of human endothelial cell senescence (J. A. M. Maier, P. Voulalas, D. Roeder, and T. Maciag, Science 249:1570-1574, 1990). To investigate the potential intracellular function of IL-1 alpha, transformed endothelial
J. A. Maier, M. Statuto, G. Ragnotti
openaire   +2 more sources

A conserved role for the ESCRT membrane budding complex in LINE retrotransposition. [PDF]

PLoS Genetics, 2017
Long interspersed nuclear element-1s (LINE-1s, or L1s) are an active family of retrotransposable elements that continue to mutate mammalian genomes.
Axel V Horn, Ivana Celic, Chun Dong, Irena Martirosyan, Jeffrey S Han   +4 more
doaj   +1 more source

Ultrastructural identification of developing proximal tubules based on three‐dimensional reconstruction

Veterinary Medicine and Science, 2021
Background The cellular mechanisms involved in the development of proximal tubules are not only associated with morphogenesis in fetal life, but also with restoration of damaged tubules in adulthood.
Jing Cong, Shi‐Jie Chang, Jesper Skovhus Thomsen, Arne Andreasen, Xue Chen, Jia Xing, Jie Zhang, Ling Gu, Xiao‐Yue Zhai   +8 more
doaj   +1 more source

Quantitative Nucleocytoplasmic Transport Assays in Cellular Models of Neurodegeneration

Bio-Protocol, 2020
Nucleocytoplasmic transport deficits are suggested to play a role in neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). Given the importance and complexity of this process, understanding when these aberrations occur and which ...
Joni Vanneste, Thomas Vercruysse, Philip Van Damme, Ludo Van Den Bosch, Dirk Daelemans   +4 more
doaj   +1 more source

SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus. [PDF]

PLoS ONE, 2011
BACKGROUND: 9b is an accessory protein of the SARS-CoV. It is a small protein of 98 amino acids and its structure has been solved recently. 9b is known to localize in the extra-nuclear region and has been postulated to possess a nuclear export signal ...
Kulbhushan Sharma, Sara Åkerström, Anuj Kumar Sharma, Vincent T K Chow, Shumein Teow, Bernard Abrenica, Stephanie A Booth, Timothy F Booth, Ali Mirazimi, Sunil K Lal   +9 more
doaj   +1 more source

Fragile X–Related Protein 1 Regulates Nucleoporin Localization in a Cell Cycle–Dependent Manner

Frontiers in Cell and Developmental Biology, 2021
Nuclear pore complexes (NPCs) are embedded in the nuclear envelope (NE) where they ensure the transport of macromolecules between the nucleus and the cytoplasm.
Arantxa Agote-Arán, Arantxa Agote-Arán, Arantxa Agote-Arán, Arantxa Agote-Arán, Junyan Lin, Junyan Lin, Junyan Lin, Junyan Lin, Izabela Sumara, Izabela Sumara, Izabela Sumara, Izabela Sumara   +11 more
doaj   +1 more source