Results 101 to 110 of about 12,305 (210)

Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochastic Drosophila retina

eLife, 2017
Drosophila color vision is achieved by comparing outputs from two types of color-sensitive photoreceptors, R7 and R8. Ommatidia (unit eyes) are classified into two subtypes, known as ‘pale’ or ‘yellow’, depending on Rhodopsin expression in R7 and R8 ...
Brent S Wells, Daniela Pistillo, Erin Barnhart, Claude Desplan   +3 more
doaj   +1 more source

Activin inhibits telomerase activity in cancer

, 2009
Activin is a pleiotropic cytokine with broad tissue distributions. Recent studies demonstrate that activin-A inhibits cancer cell proliferation with unknown mechanisms.
Charley Mackenzie-Kludas (4383187), Craig Nicholls (20016081), Fang-Xu Jiang (20016084), Indzi Katik (20016078), Shufeng Zhou (398572)   +4 more
core  

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Targeting TGF-β Mediated SMAD Signaling for the Prevention of Fibrosis

Frontiers in Pharmacology, 2017
Fibrosis occurs when there is an imbalance in extracellular matrix (ECM) deposition and degradation. Excessive ECM deposition results in scarring and thickening of the affected tissue, and interferes with tissue and organ homeostasis – mimicking an ...
Kelly L. Walton, Katharine E. Johnson, Craig A. Harrison   +2 more
doaj   +1 more source

A soluble activin Type IIA receptor induces bone formation and improves skeletal integrity

, 2008
Diseases that affect the regulation of bone turnover can lead to skeletal fragility and increased fracture risk. Members of the TGF-superfamily have been shown to be involved in the regulation of bone mass. Activin A, a TGF- signaling ligand, is present
Canalis, Ernesto, Cornwall-Brady, Milton, Seehra, Jasbir, Grinberg, Asya, Bouxsein, Mary L., Stadmeyer, Lisa, Pearsall, R. Scott, Haigis, Brendan, Underwood, Kathryn W., Ucran, Jeffrey, Kumar, Ravindra, Smith, Deanna, Werner, Eric D., Pobre, Eileen, Glatt, Vaida   +14 more
core   +1 more source

A comprehensive review of cancer‐induced cardiac wasting

British Journal of Pharmacology, EarlyView.
Cancer is frequently accompanied by cachexia, a systemic syndrome characterized by progressive loss of skeletal muscle mass, with or without loss of fat mass. Increasing evidence indicates that cancer can also induce cardiac muscle wasting, which is associated with structural cardiac remodelling, impaired contractile function and the development of ...
Alessia Lena, Muhammad Shahzeb Khan, Ulrich Keller, Lars Bullinger, Dominik P. Modest, Markus S. Anker   +5 more
wiley   +1 more source

Activin A, a Novel Chemokine, Induces Mouse NK Cell Migration via AKT and Calcium Signaling

Cells
Natural killer (NK) cells can migrate quickly to the tumor site to exert cytotoxic effects on tumors, and some chemokines, including CXCL8, CXCL10 or and CXCL12, can regulate the migration of NK cells.
Yunfeng Wang, Zhonghui Liu, Yan Qi, Jiandong Wu, Boyang Liu, Xueling Cui   +5 more
doaj   +1 more source

Identification of ActivinβA and Gonadotropin Regulation of the Activin System in the Ovary of Chinese Sturgeon Acipenser sinensis

Activin is a dimeric growth factor with diverse biological activities in vertebrates. This study aimed to investigate the regulatory role of the activin signaling pathway in the ovary of the endangered, cultured sturgeon species Acipenser sinensis.
Huan Ye, Rui Ruan, Hao Du, Chuangju Li, Huamei Yue   +4 more
core   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Human activin isoforms and variants.

, 2019
Human activin isoforms and variants.
Maurizio Pacifici (30291), Eric F. Rappaport (7406138), Paul C. Billings (2176162), Christina Mundy (3956405), Evan Yang (7406135)   +4 more
core   +1 more source