Results 81 to 90 of about 12,305 (210)

Acute Modulation of Synaptic Plasticity of Pyramidal Neurons by Activin in Adult Hippocampus

Frontiers in Neural Circuits, 2014
Activin A is known as a neuroprotective factor produced upon acute excitotoxic injury of the hippocampus (in pathological states). We attempt to reveal the role of activin as a neuromodulator in the adult male hippocampus under physiological conditions ...
Yoshitaka eHasegawa, Hideo eMukai, Hideo eMukai, Hideo eMukai, Hideo eMukai, Makoto eAsashima, Yasushi eHojo, Yasushi eHojo, Yasushi eHojo, Muneki eIkeda, Yoshimasa eKomatsuzaki, Yuuki eOoishi, Suguru eKawato, Suguru eKawato, Suguru eKawato, Suguru eKawato   +15 more
doaj   +1 more source

Activin genes in mouse genome.

, 2020
Activin genes in mouse genome.
Maurizio Pacifici (30291), Candice Bizzaro (8468856), Juliet Chung (8468859), Paul C. Billings (2176162), Christina Mundy (3956405), Evan Yang (7406135)   +5 more
core   +1 more source

Somatic cell reprogramming for Parkinson's disease treatment

Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.
The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley   +1 more source

Functional Analysis of Mature Activin A Produced by Enterokinase in Plant Cells

Rice
Molecular farming for producing biopharmaceuticals in plants is considered an excellent method to replace some of the production methods currently used, and a significant number of recombinant proteins have already shown the potential to facilitate this.
Ki-Beom Moon, Ji-Sun Park, Han-Gyeul Kim, Jae-Heung Jeon, Tae-Ho Kwon, Kyung-Sook Chung, Hyo-Jun Lee, Hyun-Soon Kim   +7 more
doaj   +1 more source

Activin signaling is an essential component of the TGF-β induced pro-metastatic phenotype in colorectal cancer

Scientific Reports, 2017
Advanced colorectal cancer (CRC) remains a critical health care challenge worldwide. Various TGF-β superfamily members are important in colorectal cancer metastasis, but their signaling effects and predictive value have only been assessed in isolation ...
Jonas J. Staudacher, Jessica Bauer, Arundhati Jana, Jun Tian, Timothy Carroll, Georgina Mancinelli, Özkan Özden, Nancy Krett, Grace Guzman, David Kerr, Paul Grippo, Barbara Jung   +11 more
doaj   +1 more source

ßA- and ßC-activin, follistatin, activin receptor mRNA and ßC-activin peptide expression during rat liver regeneration

, 2005
The mRNA expression of two activin growth factor subunits (߁- and ߃-activin), activin receptor subunits (ActRIIA, ActRIIB) and the activin-binding protein follistatin, and peptide expression of ߁-activin and ߃-activin subunits, were examined in ...
Wheatley, A, Gold, E, Fleming, Jean, Cranfield, M, Groome, N, Zhang, X, Mellor, S, Risbridger, G   +7 more
core  

TGF‐β Inhibition Attenuates Tau Accumulation and Neurodegeneration in Progressive Supranuclear Palsy Patient‐Derived Organoids

Movement Disorders, EarlyView.
Abstract Background Progressive supranuclear palsy (PSP) is a devastating 4‐repeat tauopathy with no approved disease‐modifying treatments. Recent evidence showed increased transforming growth factor‐β (TGF‐β) levels in PSP patient‐derived ventral midbrain organoids (vMOs) and serum neuronally derived exosomes. Objective This study investigated whether
Mariagrazia Talarico, Andrea Quattrone, Giorgia Lucia Benedetto, Raffaele Covello, Maurizio Martini, Valeria Zuccalà, Giovanni Cuda, Elvira Immacolata Parrotta, Aldo Quattrone   +8 more
wiley   +1 more source

Roles of the activin regulatory system in fish reproduction

, 2000
Activin (βAβA, βAβB, and βBβb) is a dimeric growth factor with diverse biological activities in vertebrate reproduction. Activin exerts its actions by binding to its specific type II and type I receptors.
Wei Ge
core   +1 more source

Human Umbilical Cord Mesenchymal Stem Cell–Derived Exosomes Attenuate Renal Fibrosis by Suppressing Fibroblast Activation via the INHBA/PI3K/AKT Pathway

Pediatric Discovery, EarlyView.
MSC‐Exo derived from human umbilical cord (HucMSC‐Exo) downregulates INHBA expression, consequently modulating the PI3K/AKT signaling cascade. This regulation attenuates renal fibroblast activation and extracellular matrix deposition, thereby exerting a renoprotective effect against fibrosis.
Meiling Chen, Chenxi Jia, Zhuocheng Shi, Bianan Zhu, Yihang Yu, Xing Liu, Feng Liu, Jianwei Chen, Tao Xu, Yuanyuan Zhang, Deying Zhang, Guanghui Wei   +11 more
wiley   +1 more source

Activin A is deeply involved in the progression of sarcopenia and leads to poor prognosis in lung cancer patients

Scientific Reports
Patients with lung cancer frequently develop sarcopenia, which severely affects quality of life. The underlying mechanisms of lung cancer sarcopenia need to be clarified because sarcopenia is strongly correlated with poor prognosis.
Yo Kawaguchi, Yoko Kataoka, Keigo Okamoto, Makoto Yoden, Takuya Shiratori, Ryosuke Kaku, Keiko Ueda, Yasuhiko Ohshio, Tomoya Terashima, Jun Hanaoka   +9 more
doaj   +1 more source